4 citations
,
October 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that epidermal stem cells in live mice exhibit coordinated intercellular Ca 2+ signaling governed by G2 cycling stem cells and mediated by Connexin43, essential for tissue-wide communication during regeneration.
3 citations
,
July 2003 in “PubMed” This study found that laser-based goniophotometry can effectively monitor changes in hair surface reflection related to color and cuticle cell tilt across different ethnic origins.
December 2025 in “Biopolymers” This study found that chemically treated hair, particularly when subjected to both acid straightening and bleaching, experiences more significant structural damage when exposed to heat, highlighting key changes in both the internal and surface components of hair fibers.
September 2023 in “Journal of The American Academy of Dermatology” This review discusses the use of Raman spectroscopy to evaluate drug penetration in alopecia treatments and suggests it may be a promising tool for enhancing the effectiveness of laser-assisted drug delivery.
198 citations
,
September 2007 in “Clinics in Dermatology” Radiofrequency devices effectively tighten skin without surgery.
92 citations
,
April 2021 in “Pharmaceutics” This review discusses the applications and challenges of lipid nanosystems in various fields, comparing techniques for evaluating nanoparticle properties, and reports no new experimental results.
36 citations
,
July 2004 in “Journal of Controlled Release” This study demonstrates that confocal laser scanning microscopy can effectively visualize the rapid diffusion and penetration pathway of a dye into the hair follicle in fresh human scalp skin.
28 citations
,
November 2009 in “Journal of Structural Biology” This study found that the molecular structure of hair is more sensitive to synchrotron X-ray radiation than its supramolecular architecture, indicating potential concerns for biological analyses using such radiation.
8 citations
,
February 2019 in “Scientific Reports” This article describes the immunofluorescence tomography method to achieve high-resolution 3-D reconstruction of epithelial tissues and reports no clinical results.
12 citations
,
October 2012 in “International Braz J Urol” This study suggests that a low daily dose of finasteride may be effective in reducing recurrent priapism episodes in children and adolescents with sickle cell disease, though larger controlled studies are needed to confirm these findings.
11 citations
,
October 2019 in “Journal of Cancer Immunology” This article discusses the role of external beam radiotherapy as a primary treatment method for cancer and reports no new clinical findings.
1 citations
,
March 2019 in “Lasers in Surgery and Medicine” This article contains the late-breaking abstracts from the 39th Annual Conference of the American Society for Laser Medicine and Surgery and does not present new research results.
January 2026 in “Inflammation and Regeneration” This review highlights that two-photon excitation microscopy is a valuable tool for visualizing live skin structures and immune responses at high resolution, though its clinical use is hindered by safety and cost issues.
August 2024 in “Nihon Ika Daigaku Igakkai Zasshi” In this study, researchers used tissue clearing techniques on human skin and scar tissue for the first time to render them optically transparent, with the aim of revealing atypical structures and improving protocols for observing scar tissue changes.
April 2016 in “Proceedings of SPIE” This study found that UV laser-induced fluorescence spectroscopy can effectively differentiate between types of alopecia in patients, showing a high correlation between blood circulation levels and tissue autofluorescence intensity.
136 citations
,
January 2013 in “International Journal of Trichology” This study found that adding microneedling to minoxidil treatment significantly improved hair growth in men with androgenetic alopecia compared to minoxidil alone across all assessed measures.
122 citations
,
April 2011 in “European Journal of Pharmaceutics and Biopharmaceutics” This review discusses the mechanisms and storage of particles in hair follicles and presents no new experimental results, highlighting the need for further research in their safe application in dermatology and cosmetics.
92 citations
,
January 1999 in “Physics in Medicine and Biology” This study developed and validated a computational model to optimize skin precooling methods for minimizing thermal damage during laser procedures.
60 citations
,
October 2010 in “Molecular Imaging and Biology” This study observed that skin pigmentation significantly attenuates bioluminescent signals in C57Bl/6 mice, complicating quantitative optical imaging and requiring consideration in experimental design.
52 citations
,
November 2013 in “European Journal of Pharmaceutical Sciences” This study examined different polymersome systems for topical finasteride delivery and found that chitosan-decorated C7 polymersomes may enhance skin retention and provide controlled drug release compared to non-decorated systems in laboratory settings.
44 citations
,
August 2017 in “Food Bioscience” This study found that betasitosterol-loaded nanostructured lipid carriers, when added to butter, improved its nutritional profile and antioxidant properties, maintaining stability over a three-month storage period.
43 citations
,
July 2016 in “European journal of pharmaceutical sciences” This study found that dexamethasone-loaded Eudragit® L 100 nanoparticles displayed controlled drug release depending on pH levels, with minimal toxicity to human fibroblasts.
32 citations
,
January 2008 in “Journal of Microencapsulation” In this study, nanocapsule-based preparations containing hinokitiol promoted hair growth in mice comparably to Minoxidil solution, as indicated by photographic and histological analysis.
28 citations
,
November 2020 in “Journal of Controlled Release” In this study, microneedles combined with finasteride nanostructured lipid carriers (FIN-NLC-MNs) were found to enhance skin penetration and specifically target hair follicles, promoting hair growth and gene regulation in androgenetic alopecia.
26 citations
,
March 2014 in “International journal of pharmaceutics” This study confirmed that the novel solid lipid microparticle formulation of adapalene demonstrated follicular penetration potential and targeted particle erosion in sebum in in vitro tests.
24 citations
,
November 2015 in “Scientific reports” This study discovered a new region in the hair cortex where intermediate filaments are both aligned with the hair's axis and orientationally ordered, influenced by the cuticle boundary.
23 citations
,
October 2006 in “Journal of Dermatological Science” This review summarizes findings on the use of ethosomes for enhanced transdermal drug delivery and reports no new clinical results.
22 citations
,
October 2019 in “International Journal of Nanomedicine” This study suggests that the hydrogel nanoparticle formulation of hair growth-promoting compounds may enhance hair follicle penetration and induce hair growth in tested models, demonstrating its potential as a hair growth treatment.
19 citations
,
June 2021 in “Tissue Engineering and Regenerative Medicine” This study found that adipose-derived stem cell exosomes promoted hair follicle regeneration in mice, resulting in a higher number of regenerated hairs and follicles compared to the control group.
18 citations
,
September 2013 in “Technology” This study introduces a new multimodal imaging technology to visualize and quantify cell dynamics in natural skin over long durations, demonstrated in GFP bone marrow-transplanted mice, to study dynamic skin regeneration.