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    Glossary Scarless Healing

    process where tissue repairs without forming scar tissue

    Scarless healing, also known as regenerative healing, refers to the process by which the body repairs damaged tissues without forming scar tissue. This type of healing restores the tissue to its original structure and function, unlike typical wound healing that often results in fibrous scar tissue. Scarless healing is observed in certain animals and in human fetal development, and it is a significant area of research for improving wound care and regenerative medicine.

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    Research 30 of 502

    1. Toward understanding scarless skin wound healing and pathological scarring F1000Research · 2019 · 113 citations
    2. Microskin‐Inspired Injectable MSC‐Laden Hydrogels for Scarless Wound Healing with Hair Follicles Advanced Healthcare Materials · 2020 · 89 citations
    3. Scarless wound healing: Transitioning from fetal research to regenerative healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018 · 79 citations
    4. An In Vivo Mouse Excisional Wound Model of Scarless Healing Plastic and Reconstructive Surgery · 2006 · 58 citations
    5. Engineering Pro‐Regenerative Hydrogels for Scarless Wound Healing Advanced Healthcare Materials · 2018 · 55 citations
    6. Scarless wound healing – a literature review Romanian Journal of Pediatrics · 2019 · 2 citations
    7. Bioadhesive Polydopamine-Vitamin A Derivative Hydrogels Reprogram the Wound Microenvironment for Scarless Wound Healing and Hair Follicle Regeneration Materials Horizons · 2026
    8. Senescence-induced reparative fibroblasts enable scarless wound healing in aged murine skin. bioRxiv (Cold Spring Harbor Laboratory) · 2025
    9. Bilayer Silk Fibroin/Sodium Alginate Scaffold Delivered hUC-MSCs to Enhance Skin Scarless Healing and Hair Follicle Regeneration with the IRE1/XBP1 Pathway Inhibition ACS Biomaterials Science & Engineering · 2023
    10. 977 The wound healing of fractional photothermolysis mimicks scarless healing with minimal myofibroblast activation Journal of Investigative Dermatology · 2019
    11. Skin wounds in the MRL/MPJ mouse heal with scar Wound Repair and Regeneration · 2006 · 51 citations
    12. Pro‐Regenerative Hydrogel Restores Scarless Skin during Cutaneous Wound Healing Advanced Healthcare Materials · 2017 · 41 citations
    13. Scarless wound healing: finding the right cells and signals Cell and Tissue Research · 2016 · 132 citations
    14. A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Oesophagus Frontiers in Cell and Developmental Biology · 2021 · 42 citations
    15. Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration Military Medical Research · 2024 · 37 citations
    16. Novel Biodegradable Polymeric Microparticles Facilitate Scarless Wound Healing by Promoting Re-epithelialization and Inhibiting Fibrosis Frontiers in Immunology · 2018 · 37 citations
    17. Fetuin-A: A Major Fetal Serum Protein that Promotes “Wound Closure” and Scarless Healing Journal of Investigative Dermatology · 2007 · 21 citations
    18. An injectable photo-crosslinking silk hydrogel system with biphasic release of BTXA and 5-Fu promotes scarless wound healing RSC Advances · 2026
    19. Temperature‐sensitive hydrogel releasing pectolinarin facilitate scarless wound healing Journal of Cellular and Molecular Medicine · 2024
    20. Dermal Fibrosis and the Current Scope of Hydrogel Strategies for Scarless Wound Healing Fibrosis · 2024 · 1 citations
    21. Impact of different mating and surgical protocols on the establishment of a mouse model for fetal scarless skin healing Biological Procedures Online · 2025
    22. New insights into balancing wound healing and scarless skin repair Journal of Tissue Engineering · 2023 · 108 citations
    23. Food-derived Crassostrea gigas peptides self-assembled supramolecules for scarless healing Composites Part B: Engineering · 2022 · 2 citations
    24. In Situ Integration of Porous Polyethylene Nanomembrane with Wound Exudates for Scarless Healing bioRxiv (Cold Spring Harbor Laboratory) · 2024
    25. A study of scarless wound healing through programmed inflammation, proliferation and maturation using a redox balancing nanogel Journal of Biomedical Materials Research Part A · 2024 · 3 citations
    26. Nematic Fibrin Fibers Enabling Vascularized Thrombus Implants Facilitate Scarless Cutaneous Wound Healing Advanced materials · 2023 · 8 citations
    27. Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways Cell Proliferation · 2025
    28. Accelerated, injectable, self-healing, scarless wound dressings using rGO reinforced dextran/chitosan hydrogels incorporated with PDA-loaded asiaticoside International Journal of Biological Macromolecules · 2024 · 17 citations
    29. MSC-derived sEV-loaded hyaluronan hydrogel promotes scarless skin healing by immunomodulation in a large skin wound model Biomedical Materials · 2022 · 39 citations
    30. Sprayable biomimetic double mask with rapid autophasing and hierarchical programming for scarless wound healing Science Advances · 2024 · 47 citations