28 citations
,
November 2003 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” The normal human prostate does not significantly affect blood DHT levels.
11 citations
,
March 2019 in “Assay and Drug Development Technologies” Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.
3 citations
,
May 2010 in “Endocrinology” The mouse model suggests male pattern baldness may be due to an enzyme increasing DHT and higher androgen receptor levels in hair follicles.
2 citations
,
June 2011 in “Expert Review of Dermatology” Female pattern hair loss involves thinning hair on crown and frontal scalp, diagnosed by hair ratio, and treated with minoxidil, antiandrogens, or hair transplantation.
1 citations
,
August 2002 in “Zeitschrift für Hautkrankheiten” Male androgenetic alopecia involves hair follicle miniaturization due to DHT, with potential treatments using inhibitors and blockers.
January 2018 Hormones, especially testosterone and DHT, are key for penis development and function, and testosterone therapy may help with erectile dysfunction in those with low levels.
May 2005 in “Aktuelle Dermatologie” Shampoos have evolved to address individual hair and scalp needs, and treatments like Minoxidil and Finasteride help with hair loss.
49 citations
,
January 2004 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.
42 citations
,
February 1998 in “The Journal of Steroid Biochemistry and Molecular Biology” PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.
13 citations
,
January 2010 in “Advances in Biochemical Engineering / Biotechnology” Understanding hair biology is key to developing better treatments for hair and scalp issues.
7 citations
,
June 2022 in “Journal of pharmaceutical and biomedical analysis” The method can measure multiple steroids in human hair to study long-term steroid metabolism, especially in newborns and children.
May 2024 in “Journal of cosmetic dermatology” Heat-treated Limosilactobacillus fermentum with menthol, salicylic acid, and panthenol promotes hair growth and balances scalp microbiome in people with androgenetic alopecia.
8 citations
,
January 1996 in “Springer eBooks” Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.
8 citations
,
May 1982 in “Journal of Endocrinology/Journal of endocrinology” Rat skin takes up and processes testosterone differently than other organs, with testosterone being more important for the skin than its metabolite 5α-DHT.
1 citations
,
December 2017 in “Annals of Dermatological Research” 7 citations
,
January 2012 in “International Journal of Trichology” A man with Woolly Hair Syndrome had very curly, fragile hair, and doctors used a special scalp examination to diagnose him without invasive tests.
November 2015 in “Springer eBooks” Hair loss treated with minoxidil, finasteride, laser/light, hair transplant, and scalp prostheses; more research needed for skin of color.
1 citations
,
October 2002 in “Dermatologic Surgery” Minoxidil can increase hair density, speed up regrowth in transplanted hair, and slow down further hair loss, especially beneficial for women, young men with thinning hair, and those wanting to reconstruct the back of the scalp.
32 citations
,
December 2009 in “Archives of Dermatological Research” Dihydrotestosterone increases certain inflammatory signals in skin cells, potentially contributing to acne.
July 2023 in “Clinica Chimica Acta” Finasteride and dutasteride effectively reduce DHT in hair, which may help evaluate their treatment success for hair loss.
36 citations
,
February 2010 in “Journal of Investigative Dermatology” Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.
3 citations
,
February 2008 in “Basic and clinical dermatology” Telogen Effluvium is a hair loss condition where treatment involves identifying and managing its triggers.
1 citations
,
August 2023 in “Clinical, Cosmetic and Investigational Dermatology” A condition with certain scalp changes may come before acne keloidalis nuchae and other similar hair loss disorders.
3 citations
,
September 2016 in “Clinical, cosmetic and investigational dermatology” Sphinganine can reduce hair loss and improve scalp health.
1 citations
,
February 2021 in “Journal of Dermatological Science” The gene LRRC15 is more active in balding areas of the scalp compared to non-balding areas.
149 citations
,
January 2011 in “Nature reviews. Urology” Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.
6 citations
,
January 2022 in “Journal of Investigative Dermatology” Male pattern baldness is linked to higher levels of a certain receptor in the scalp, which leads to the shrinking of blood vessels and hair loss. Early treatment targeting this receptor could be more effective.
122 citations
,
January 2011 in “Journal of Dermatological Science” Male pattern baldness involves hormones and cell signals affecting hair growth.
59 citations
,
June 2014 in “Expert Opinion on Therapeutic Targets” The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.
47 citations
,
January 2017 in “Molecular and Cellular Endocrinology” Androgens prevent hair growth by changing Wnt signals in cells.