Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study reported that pathways related to apoptosis, cell proliferation, and WNT signaling might be key drivers of hair loss in androgenetic alopecia, guiding potential targets for therapy development.

This study found that aged C57BL/6 mice sub-strains exhibit distinct aging patterns, including differences in survival rates, body weight changes, and disease incidences, providing valuable insights for geriatric research using these mice models.

This chapter reviews the role of nanoparticles in wound healing, exploring current therapies, developments, and future directions, but reports no new clinical results.

In this study, certain genetic variations in the ESR1 and ESR2 genes were strongly associated with polycystic ovary syndrome and related metabolic issues in Tunisian women.

This study explored peripheral blood immune dysregulation in alopecia areata through single-cell analyses, identifying systemic changes linked to disease severity and key signaling roles for monocytes, NK cells, and memory T cells, suggesting potential therapeutic targets.

In this review, the authors discuss recent advancements in underwater adhesion technologies, specifically highlighting mussel-inspired catechol-based adhesives, which offer strong underwater bonding through various interfacial interactions and the influence of dopamine-modified polymeric tissue adhesives.

This study presents a method using liquid chromatography tandem mass spectrometry to quantify biotin in plasma and serum, and explores how high biotin intake can interfere with diagnostic immunoassays that utilize biotin-streptavidin technology, potentially leading to misdiagnosis of endocrine disorders.

This narrative review found that while AI-based tools in dermatology, particularly for hair disorder assessment, have potential to enhance clinical practice by improving objectivity and personalization, they currently serve mainly a complementary role and face challenges like methodological limitations and data bias.

This study investigated the molecular mechanisms behind cashmere goat coat types by analyzing gene expression during hair follicle development stages, identifying regulatory pathways involved in metabolism, immune response, and the quiescent state of follicles, potentially aiding in genetic selection for improved cashmere production.

This review explores how radiation-induced hair graying can be used as a model to study the mechanisms behind hair graying, focusing on cellular senescence and potential therapeutic targets to address age-related changes. Results are not provided.

Wnt/β-catenin signaling is crucial for cell fusion in placental development.

This study found that WNT10A is significantly upregulated in human esophageal squamous cell carcinoma and is associated with enhanced tumor cell migration, invasion, and poor survival.

This study found that the 11R-No. 10 peptide, delivered transdermally, significantly inhibited melanogenesis and produced a whitening effect in a UV-induced sun-tanning guinea pig model without cytotoxicity.

This review article highlights recent advancements in smart hydrogels as promising solutions for diabetic wound management, emphasizing their ability to respond to wound environments and deliver targeted therapies, while addressing limitations of traditional dressings.

This review discusses the potential of using human pluripotent stem cells to generate new hair follicles, though practical challenges remain before it can be applied for hair restoration.

This study explored recent advancements in 3D bioprinting for head and neck defects, highlighting how bioinks and scaffolds may improve treatment customization and functionality by mimicking native tissue features. The research also examined challenges like biocompatibility and regulatory requirements on the path to clinical use.

This study found that the active use of androgen deprivation therapy was not associated with a reduced risk of death in prostate cancer patients with COVID-19.

This review explores the different types of hydrogels used to repair diabetic ulcers, the mechanisms involved, and the limitations in developing these technologies for clinical use, but it reports no new clinical results.

This study found that subcutaneous adipose tissue-derived extracellular vesicles (AT-EVs) protect skin from photodamage by enhancing fibroblast proliferation and reducing oxidative stress compared to those from adipose-derived stem cells.

This review discusses the growing importance of hydrogel scaffolds in skin wound healing, highlighting their unique properties and recent advancements in their use for treating difficult tissue damage, particularly within tissue engineering.

This review examines the potential of swellable microneedles in drug delivery and diagnostics, highlighting innovations and challenges in their use for chronic disease treatment, but noting that issues like physiological responsiveness and long-term stability still require research.

This review reports that sodium alginate-based hydrogels show promise in biomedical applications due to their biocompatibility and versatility, but challenges such as mechanical strength and stability remain, highlighting the need for continued research to facilitate their clinical transition.

This review discusses how polymers can be customized to develop biomaterials that mimic the extracellular matrix, exploring their potential in biomedical and biotechnological applications by triggering cell functions similar to natural physiological systems.

This study found that the alcohol extract of Vernonia anthelmintica may counteract stress-induced hair follicle growth inhibition in mice, potentially offering a new approach for treating stress-related hair loss.

This review highlights new perspectives in genomics and epigenomics for skin rejuvenation, comparing innovative strategies like senolytics and DNA repair modulators with classical treatments, and emphasizing the importance of tailoring therapies using individual genomic profiles for personalized anti-ageing approaches.

This review focuses on recent advances in smart responsive polymer microneedles, which offer precise, on-demand drug delivery triggered by external or physiological stimuli, highlighting significant research implications for transdermal drug administration according to this source.

This review discusses various gene therapy and non-viral delivery methods to promote angiogenesis for chronic wound healing, but it reports no new clinical results.

This review examines the potential of biomaterial-based wound dressings in managing diabetic foot ulcers, highlighting their versatility and therapeutic properties for promoting wound healing in individuals with diabetes mellitus.

This review highlights the challenges in developing nano-scale drug delivery systems for natural antioxidants in wound healing, pointing out issues like low solubility and skin permeability, and discusses potential solutions such as combining polymers and lipids to enhance delivery effectiveness.

This study found that the systemic wrinkled skin phenotype in Xiang pigs involves gene expression changes and genetic variations associated with oxidative stress and extracellular matrix components, resembling features seen in Shar-Pei dogs.