Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This research outlines a protocol for a systematic review to map the evidence on alopecia areata in Sub-Saharan Africa, aiming to identify research gaps and guide future studies and policy decisions related to this condition in the region.

This study identified a homozygous missense mutation in the KRTHB5 gene linked to pure hair–nail ectodermal dysplasias in a large consanguineous Pakistani family, providing new insights into the condition's molecular pathogenesis.

This study examined gene expression in cashmere goats and identified key pathways and molecular regulators that influence hair follicle growth stages and melatonin's role in promoting cashmere growth.

In this study, researchers reported that the Pinkie mutation in mice, affecting RXRa activity, leads to skewed Th1 development and suggests RXRa's role in Th2 differentiation, impacting immune responses.

This project reports that Vitex rotundifolia may have cancer chemotherapeutic potential due to its ability to inhibit MAP kinase phosphorylation, suggesting further investigation into its active constituents.

This study identified 1965 different metabolites in various tissues of *Oresitrophe rupifraga* Bunge using a targeted metabolomics approach and found significant metabolic differences between its aboveground and underground parts, providing insights into the plant's unique growth traits and potential cultivation and utilization.

This study explored the role of the histone modification H3K4me3 in cashmere goat dermal papilla cells, finding that increased levels enhanced cell proliferation and activated Wnt signaling genes, suggesting H3K4me3's involvement in hair follicle development through regulation of the gene RSPO3.

This article reviews drug repurposing as a strategy to overcome challenges in drug discovery, emphasizing AI and machine learning's role, but presents no new clinical results.

In this study, AFM-based indentation was used to assess mechanical properties of murine skin wounds at two healing stages, revealing that early wounds exhibit stiffer hyperproliferative epithelium compared to granulation tissue, and highlighting significant influences of surface roughness on tissue stiffness measurements.

This study investigated the effects of different relaxer treatments on African-American hair, finding lab-made relaxer solutions caused less damage to hair topography than commercial systems.

This review compiles and discusses the ethnomedicinal uses, pharmacological activities, and phytochemistry of pomegranate, suggesting potential future applications in drug discovery for various ailments but reports no new clinical results.

This study identifies a mechanism where dsRNA activates TLR3 to induce RA production, promoting hair follicle regeneration in mice and suggesting a potential role in human tissue regeneration.

This study found that chemical and photochemical oxidative processes modify the main classes of proteins in hair, confirmed through microspectrophotometric, fluorescence microscopy, and electrophoretic methods.

This perspective highlights how advancements in single-cell sequencing and digital pathology can help understand the complex mechanisms of immune responses, fibrosis, and tissue remodeling related to medical implants, aiming to address the challenges of implant-related tissue reactions reported in this study.

This study identified mutations in the STUB1 gene linked to hereditary cerebellar ataxia with cognitive impairment, revealing potential effects on protein function and patient symptoms, including accelerated aging.

This study found that in mouse skin, the activation of stem/progenitor cells is synchronized across different niches during growth, with the glutamate transporter SLC1A3 playing a crucial role in this process.

This study examined the structural and biochemical mechanisms of human lipocalin prostaglandin D synthase, detailing substrate and product binding processes at the catalytic site and suggesting potential for drug delivery targeting hydrophobic molecules.

This study explores how EGFR signaling impacts skin inflammation and follicular integrity during hair eruption, aiming to identify druggable pathways to mitigate skin inflammation in cancer patients receiving EGFR inhibitors.

This study identified a genetic locus associated with rhabdomyosarcoma susceptibility in mice and found that specific differentiation markers are linked to the regression of basal cell carcinoma.

This review highlights that genetically engineered mouse models are valuable for studying melanoma development and progression by mimicking human skin biology, revealing key signaling pathways and molecular mechanisms that contribute to melanoma heterogeneity and offering insights into potential therapeutic targets.

In this study, botulinum toxin type A did not improve clinical features in patients with recalcitrant alopecia totalis or alopecia universalis over a four-month period.

This review discusses the composition, activation, and regulation of the JAK/STAT pathway and highlights its role and inhibitors in various diseases, but reports no new experimental results.

This review describes how curcumin, a compound derived from turmeric, affects various cell signaling pathways involved in cancer progression, highlighting its potential as a therapeutic agent with fewer side effects compared to conventional cancer treatments.

This study identified a coexpression network and key genes associated with thyroid eye disease, potentially aiding in its treatment and diagnosis.

This study provided the crystal structure of the human steroid 5α-reductase 2 enzyme and identified key molecular mechanisms for testosterone reduction and finasteride inhibition, aiding in understanding disease-causing mutations and potentially facilitating new drug development.

This study used computational modeling to identify key genes and miRs involved in cardiac aging, finding a strong relationship supported by literature and some experimental validation in aged mouse hearts.

This collection of reviews, edited by Ken Lukowiak and Janis Weeks, explores diverse sensory systems across species, including olfaction, echolocation, magnetoreception, and visual adaptations, without presenting new experimental results.

In this case study, treatment with methylene blue successfully improved blood pressure in a patient with refractory vasodilatory shock due to massive minoxidil ingestion, highlighting its potential as an adjunctive therapy.

This review examines the potential of K18 as a diagnostic and prognostic marker in epithelial-derived tumors, highlighting its specific expression in tumor tissues and interaction with proteins involved in tumor progression, without reporting new clinical findings.

This article reviews challenges and errors in performing Mohs surgery, emphasizing vigilance in maintaining its procedural integrity for successful treatment outcomes, and reports no new clinical findings.