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Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.

NCSTN gene mutation causes abnormal skin cell differentiation and more inflammation, contributing to Hidradenitis Suppurativa.

New culture method keeps human skin stem cells more stem-like.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

Researchers isolated a new type of stem cell from mouse skin that can renew itself and turn into multiple cell types.

Damaged hair follicles make mice more prone to skin inflammation and skin cancer after UV exposure.

A specific RNA molecule, circCOL1A1, affects the growth and quality of goat hair by interacting with miR-149-5p and influencing cell growth pathways.

Dog hair follicle stem cells can turn into fat cells.

Ginsenoside Rd may help improve skin aging by increasing collagen in the skin.

Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.

Removing STAT5 from 3D-cultured human skin cells reduces their ability to grow hair.

Kaempferol helps skin stem cells grow and may improve skin thickness due to its 3-OH group.

Most patients experienced mild to moderate skin problems during a trial for a desmoid tumor treatment.

MPZL3 is crucial for seborrheic dermatitis development.

Rosacea is a skin condition with unclear causes, classified into four subtypes.

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Wnt ligands are crucial for hair growth and repair.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Stem cell niches support, regulate, and coordinate stem cell functions.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.