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    Glossary Rutin

    bioflavonoid found in plants with antioxidant and anti-inflammatory properties

    Rutin, also known as Rutoside or Quercetin-3-rutinoside, is a bioflavonoid found in various plants, including buckwheat, citrus fruits, and certain berries. It is known for its antioxidant properties and potential health benefits, such as improving blood circulation, reducing inflammation, and strengthening blood vessels. In the context of hair and alopecia, rutin may help by enhancing scalp health and potentially reducing hair loss through its anti-inflammatory and circulatory benefits.

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    1. Preparation and Characterization of Rutin-loaded Nanophytosomes Pharmaceutical Sciences · 2015 · 63 citations
    2. Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats Journal of Ovarian Research · 2016 · 40 citations
    3. Rutin Stabilises β-Catenin Through GSK3β Inhibition to Promote Hair Follicle Regeneration. PubMed · 2026
    4. Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse Mechanisms of development · 2002 · 232 citations
    5. Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled EMBO journal · 2002 · 127 citations
    6. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression (Catagen) by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005 · 92 citations
    7. Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin 2008 · 91 citations
    8. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling Developmental biology · 2008 · 84 citations
    9. Self-assembled polymeric nanocarriers for the targeted delivery of retinoic acid to the hair follicle Nanoscale · 2015 · 59 citations
    10. Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk Nature Communications · 2014 · 51 citations
    11. Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle 2007 · 48 citations
    12. Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3 Nature Communications · 2019 · 47 citations
    13. The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events. PubMed · 1998 · 44 citations
    14. In situ detection of retinoid-X receptor expression in normal and psoriatic human skin 1995 · 42 citations
    15. Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type Biomolecules · 2019 · 41 citations
    16. Molecular cloning of two novel types of peptidylarginine deiminase cDNAs from retinoic acid‐treated culture of a newborn rat keratinocyte cell line FEBS Letters · 1998 · 39 citations
    17. Treatment of Psoriasis vulgaris with a New Retinoic Acid Derivative Ro 10-9359 Dermatology · 1977 · 39 citations
    18. Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1 Journal of cellular physiology · 1996 · 37 citations
    19. Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth. Acta Dermato Venereologica · 1997 · 34 citations
    20. The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease Journal of Investigative Dermatology · 2016 · 31 citations
    21. Cutaneous Retinoic Acid Levels Determine Hair Follicle Development and Downgrowth 2012 · 31 citations
    22. Hair Cycle-Specific Immunolocalization of Retinoic Acid Synthesizing Enzymes Aldh1a2 and Aldh1a3 Indicate Complex Regulation 2004 · 29 citations
    23. Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer Biological & pharmaceutical bulletin · 2012 · 28 citations
    24. Retinoic acid in the treatment of eruptive vellus hair cysts Journal of the American Academy of Dermatology · 1981 · 28 citations
    25. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations
    26. Retinoic Acid and Mouse Skin Morphogenesis. I. Expression Pattern of Retinoic Acid Receptor Genes During Hair Vibrissa Follicle, Plantar, and Nasal Gland Development Journal of Investigative Dermatology · 1994 · 24 citations
    27. Cellular localization of retinoic acid receptor-gamma expression in normal and neoplastic skin. PubMed · 1992 · 23 citations
    28. Retinoid Metabolism Is Altered in Human and Mouse Cicatricial Alopecia Journal of Investigative Dermatology · 2012 · 22 citations
    29. DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen in Combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo BioMed Research International · 2019 · 20 citations
    30. Antipsoriatic Activity of a New Synthetic Retinoid Archives of dermatology · 1983 · 20 citations