January 2024 in “La Ciencia al Servicio de la Salud y Nutrición” Spironolactone is effective and safe for treating hair loss, excessive hair growth, and acne.
August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Too much β-catenin activity can mess up the development of mammary glands and make them more like hair follicles.
There are many treatments for common hair loss, but more trials are needed to decide which are best.
Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.
January 2023 in “Open veterinary journal” Cow blood vessel cell secretions helped heal rat burn wounds and may treat burns and hair loss.
December 2022 in “PubMed” 1 citations,
October 2022 in “PubMed” Patients generally have positive attitudes towards using topical Minoxidil for hair loss treatment.
119 citations,
December 2016 in “American journal of human genetics” Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.
98 citations,
March 2019 in “Frontiers in immunology” Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.
48 citations,
April 2019 in “PloS one” Alopecia areata patients have more Propionibacterium acnes and less Staphylococcus epidermidis on their scalps.
29 citations,
October 2020 in “Environmental health perspectives” Five preservatives may disrupt hormone function and need more health and environmental risk assessment.
29 citations,
April 2019 in “Acta neuropathologica communications” Stopping mitochondrial respiration can prevent brain cancer spread in skin cancer patients, and plant compound β-sitosterol could help achieve this.
10 citations,
February 2021 in “International Journal of Nanomedicine” 1 citations,
December 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Keeping β-catenin levels high in mammary cells disrupts their development and branching.
1 citations,
April 2023 in “International Journal of Molecular Sciences” New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.
1 citations,
July 2022 in “Pakistan biomedical journal” Transethosomes improve drug delivery through the skin by overcoming the outer skin layer's barrier.
1 citations,
May 2021 in “BMC Proceedings” The document concludes that more research is needed to reduce frequent hospital visits, addiction medicine education improves with specific training, early breast cancer surgery findings are emerging, nipple smears are not very accurate, surgery for older melanoma patients doesn't extend life, a genetic condition in infants can often be treated with one drug, doctors are inconsistent with blood clot medication, a certain gene may protect against cell damage, muscle gene overexpression affects many other genes, and some mitochondrial genes are less active in mice with tumors.
April 2024 in “Tạp chí Y học Thảm hoạ và Bỏng” Choosing the right treatment for hair loss is complex and depends on effectiveness, side effects, practicality, and cost.
Skin stem cells in hair follicles are important for touch sensation.
Hair follicle stem cells are crucial for touch sensation and proper nerve structure in mice.
March 2023 in “Clinical, Cosmetic and Investigational Dermatology” This systematic review evaluated the efficacy and safety of oral and topical spironolactone in treating androgenetic alopecia (AGA) across 7 studies with 618 patients (65 men and 553 women). The review found that spironolactone, both oral and topical, showed promise in increasing hair density and diameter with manageable adverse effects. Specifically, 81% of 295 female patients on oral spironolactone reported hair growth improvement, and combined therapy with spironolactone and other treatments was effective in 94.5% of 273 patients. Adverse effects were generally mild, including menstrual disorders and headaches. The review supports spironolactone as a viable treatment for AGA, especially for those unresponsive to traditional therapies like minoxidil and finasteride, though more high-quality studies are needed to further validate these findings.
December 2022 in “JEADV Clinical Practice” 30 citations,
July 2019 in “PloS one” Patients with Alopecia areata have fewer specific immune cells that normally regulate the immune system, which may contribute to the condition.
112 citations,
January 2014 in “Molecular and cellular therapies” Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.
65 citations,
February 2015 in “Neuro-Oncology” Alisertib was found to be an effective and tolerable treatment for children with recurrent brain tumors.
23 citations,
January 2021 in “Biomedicine & Pharmacotherapy” DHT stops hair regrowth in mice, similar to human hair loss.
21 citations,
May 1976 in “Archives of Dermatology” Stopping fluoride toothpaste use might improve perioral dermatitis.
7 citations,
January 2017 in “International Journal of Dermatology” Superficial cryotherapy significantly improves eyebrow hair growth in alopecia universalis patients.
1 citations,
May 2023 in “Frontiers in endocrinology” A new MBTPS2 gene variant disrupts fat metabolism and collagen production, causing Osteogenesis imperfecta.
1 citations,
December 2020 in “Journal of Chemical and Petroleum Engineering” The Gas-Antisolvent process can be effectively modeled and optimized to create Finasteride, a hair growth drug.