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The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Human skin can make serotonin and melatonin.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

Ectodin integrates BMP, SHH, and FGF signals in developing ectodermal organs.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Low iron and L-lysine levels can cause hair loss in women, and increasing these nutrients can reduce hair shedding.

Fat cells help recruit healing cells and build skin structure during wound healing.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

The method can effectively extract biomedical information without needing expert annotation, performing better than previous models.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Sorafenib is effective in treating Desmoid Tumor/Deep Fibromatosis.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Noggin is necessary to start the hair growth phase in skin after birth.

More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.

Interferon alfa-2a is effective for treating cutaneous T cell lymphoma but has significant side effects.

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

PGD2 stops hair growth and is higher in bald men with AGA.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Sebocytes play a key role in controlling androgen levels in human skin.

The ZIP7 gene helps control zinc levels in cells by moving zinc from the Golgi apparatus to the cytoplasm.

Dermatologists need to understand hair products to treat hair and scalp issues better.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Targeted cancer therapies often cause serious skin problems that need careful management.

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.