37 citations
,
July 1999 in “The EMBO Journal” Overexpression of certain genes can shorten hair by disrupting the hair-growth cycle.
27 citations
,
January 2006 in “Colloids and Surfaces B: Biointerfaces” This study found that in vitro, cultured bulge cells from human hair follicles possess properties of primitive cells, supporting the hypothesis that hair follicle stem cells reside in the bulge area.
20 citations
,
September 2004 in “Journal of Anatomy” This study suggests that the structure and function of the inner root sheath in mammalian hair may have evolved from simpler forms seen in monotremes, aiding in hair exit without damaging the epidermis.
18 citations
,
January 2019 in “Experimental Dermatology” This study suggests that damaged anagen hair follicles have the capability to repair themselves and resume growth by mobilizing extra-bulge epithelial cells, particularly after injuries like chemotherapy and radiotherapy.
17 citations
,
June 2012 in “Journal of experimental zoology. Part B, Molecular and developmental evolution” This review explores theories on the evolution of hair from synapsid scales and glands, proposing mechanisms supported by comparative studies, but reports no new experimental findings.
16 citations
,
April 1978 in “Genetics Research” This study found that asebic mice exhibit abnormal sebaceous gland differentiation and insufficient sebum production due to defective regulation of cell processes, despite possessing normally developing sebaceous glands initially.
14 citations
,
January 2009 in “Experimental Dermatology” In this study, researchers used a rodent model to uncover key changes in how hair fibers detach, suggesting that the exogen phase should be subdivided based on club fiber status.
12 citations
,
October 2020 in “Scientific Reports” In this study, Nec-1s was found to promote hair growth and may target necroptosis and the Wnt/β-catenin pathway for potential treatment of hair loss.
10 citations
,
August 2018 in “Experimental Dermatology” This study found that DECORIN promotes the proliferation and migration of outer root sheath keratinocytes in vitro and maintains the hair anagen phase in mice.
10 citations
,
May 2006 in “Agricultural Sciences in China” This study found that a hydroponic buffer solution induced the formation of abundant long root hairs, termed "hedgehog roots," in several plant species but not in onions.
7 citations
,
June 2015 in “The anatomical record” This study in Hexi cashmere goats found that secondary follicle activity increases with time, and Hoxc13 expression varies significantly across different growth stages, suggesting a role in follicle activity.
6 citations
,
April 1996 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” This study suggests that TGF-alpha may function in an autocrine or juxtacrine manner rather than promoting cell proliferation during hair growth cycles in ferrets and sheep.
5 citations
,
March 2001 in “Journal of biomechanics” This study found that anagen hairs require less force to be extracted than telogen hairs in an in vitro pig skin model, indicating different anchorage mechanisms.
4 citations
,
January 2018 in “Advances in Experimental Medicine and Biology” This article discusses the structures surrounding hair follicles and introduces aspects like follicle groups and the dermal sheath, but it reports no new research findings.
3 citations
,
July 2011 in “Folia Histochemica et Cytobiologica” This study concluded that the inner root sheath inhibits the expression of certain differentiation markers in hair bulbs, with calcium-induced changes paralleling those seen in hair follicle mid-segments.
1 citations
,
May 2017 in “InTech eBooks” This chapter reviews signaling pathways related to androgenic alopecia in dermal papilla cells of balding human scalps, integrating published information and analysis of molecular interactions, without reporting new clinical results.
November 2025 in “Nature Communications” This study used a 3D live imaging system to map cell dynamics in human hair follicles, revealing patterns of cell movement and division that help explain hair fiber extrusion during hair growth.
January 2016 in “Research Explorer (The University of Manchester)” Activating the Eda/Edar pathway improves wound healing by enhancing hair follicle growth.
September 2023 in “Stem cell reviews and reports” This study introduces a new method to isolate stem cells from the hair follicle outer root sheath of equine skin, demonstrating that these cells, named eMSCORS, proliferate efficiently and can differentiate similarly to adipose tissue-derived MSCs, offering a promising alternative for equine veterinary applications.
March 2014 in “Journal of The American Academy of Dermatology” TNF-a may not be as involved in certain types of hair loss as previously thought.
January 2006 in “Carl von Ossiezky University of Oldenburg” This study observed that unpigmented keratinocytes saturate quickly with foreign substance uptake compared to pigmented melanocytes, where melanin significantly enhances binding.
280 citations
,
January 2004 in “The EMBO Journal” AGC2-1 protein is essential for root hair growth in Arabidopsis.
66 citations
,
May 2002 in “The Plant Journal” This study identified a mutant in Arabidopsis with shorter root hairs due to early growth cessation, implicating the IRE gene in regulating root hair growth duration.
30 citations
,
October 2020 in “Frontiers in Plant Science” In this study, the combination of arsenic toxicity and hypoxia in Arabidopsis thaliana altered root development through stress-specific root growth phenotypes and changes in phosphate starvation response, energy metabolism, and redox signaling.
This study found that treating tobacco roots with specific peptides like Gly, GlyGly, and GlyAsp significantly increased root hair development and influenced gene expression, potentially through an epigenetic mechanism.
In this study of hydroponically grown tomatoes, the authors reported that adding melatonin at 10-30 μmol·L-1 effectively enhanced lateral root development, root hair growth, biomass accumulation, and root activity by influencing related gene expression and hormone levels.
19 citations
,
August 2022 in “Plant Signaling & Behavior” This article reviews how calcium and reactive oxygen species gradients and oscillations interact to promote root hair cell expansion and reports no new experimental findings.
555 citations
,
July 2001 in “Genes & Development” This study found that Tcf3 and Lef1 differently regulate cell differentiation in multipotent skin stem cells, with Tcf3 promoting follicle-like features and Lef1, when modified, promoting sebocyte differentiation.
37 citations
,
September 2008 in “Plant Signaling & Behavior” In this study, overexpression of the gene OsPHR2 in rice led to increased root growth and phosphate accumulation in shoots, suggesting its role in phosphate signaling and homeostasis.
2 citations
,
October 2023 in “Science advances” In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.