Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study observed that decreased nucleolar organizing region protein synthesis in hair root cells is correlated with hair loss in humans.

This review explores theories on the evolution of hair from synapsid scales and glands, proposing mechanisms supported by comparative studies, but reports no new experimental findings.

In this study, researchers found that overexpression of the hairless protein in Hr mutant mice disrupts inner root sheath formation by downregulating Dlx3 and associated keratins in hair follicle development.

This study found that asebic mice exhibit abnormal sebaceous gland differentiation and insufficient sebum production due to defective regulation of cell processes, despite possessing normally developing sebaceous glands initially.

In this study, EGCG from green tea promoted mink hair follicle growth and cell proliferation at specific concentrations, potentially through activation of Shh and AKT signaling pathways.

In human follicular cells, this study found that an Annurca apple-based dietary supplement may stimulate the production of hair keratins, suggesting potential benefits for hair growth.

This study found that mesenchymal cell processes from the dermal papilla contact epithelial hair matrix cells through gaps in the basal lamina during hair matrix cell differentiation in mouse vibrissa follicles.

In this study, Nec-1s was found to promote hair growth and may target necroptosis and the Wnt/β-catenin pathway for potential treatment of hair loss.

This study found that GFRα2 influences cell size but not survival or target innervation of Ret-positive low-threshold mechanoreceptors in mouse dorsal root ganglia, differing from its role in nonpeptidergic nociceptors.

This study identified a missense mutation in the keratin 71 gene as the cause of autosomal dominant woolly hair/hypotrichosis in a Japanese family, marking the first human mutation in KRT71 linked to a hair disorder.

This study demonstrates that Rac1 activity is essential for normal hair follicle formation but influences hair structure and pigmentation, in terminal differentiation, through alterations in hair shaft, cuticle, and pigmentation organization.

This study used single-cell RNA sequencing to map the cellular composition of sheep hair follicles, revealing differentiation pathways and potential molecular mechanisms for wool curvature, which may inform sheep breeding.

This study found that DECORIN promotes the proliferation and migration of outer root sheath keratinocytes in vitro and maintains the hair anagen phase in mice.

This study found that TGF-β1 expression in follicular tumors correlates with differentiation degree and suggests its potential role alongside p63 in differentiating between sebaceous and follicular tumors.

This study found that injecting keratin into the skin of mice promoted hair growth, potentially through keratin's interaction with hair-forming cells and changes in the microenvironment.

This study suggests that TGF-alpha may function in an autocrine or juxtacrine manner rather than promoting cell proliferation during hair growth cycles in ferrets and sheep.

This study found that anagen hairs require less force to be extracted than telogen hairs in an in vitro pig skin model, indicating different anchorage mechanisms.

The researchers reported that applying proteolytic enzymes to mice skin negatively affected hair follicles, leading to degeneration and potential impairment of stem cells from the bulge area.

In this study, the PLP2 gene was found to promote secondary hair follicle development in Liaoning cashmere goats, with its expression negatively regulated by melatonin and potentially affecting follicle development via the BMP pathway.

This study concluded that the inner root sheath inhibits the expression of certain differentiation markers in hair bulbs, with calcium-induced changes paralleling those seen in hair follicle mid-segments.

In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.

In this study, the researchers developed a new protocol using human-induced pluripotent stem cells to efficiently create skin hair follicle organoids, which may aid in optimizing hair follicle growth and exploring treatments for alopecia.

This study demonstrated that autologous mesenchymal stem cells from hair follicles, when combined with a novel gelatin-based hydrogel, showed promising osteogenic potential and could offer a non-invasive alternative for bone regeneration.

This study found that Phaeodactylum tricornutum extract enhanced hair follicle cell proliferation, indicated by increased keratin and ERK1/2 signaling, suggesting its potential for hair care applications.

This article explains the significance of culturing the pilosebaceous unit for studying related diseases and skin epithelial stem cells, but it reports no new findings.

This study observed that activating the Wnt/β-catenin pathway enhances hair follicle stem cell proliferation and differentiation, promoting hair growth and wound healing, and demonstrated the potential for outer root sheath transplants to aid skin repair, although challenges remain for clinical application.

This study evaluated nanovesicles derived from Polygonum multiflorum roots, finding that they promote dermal papilla cell proliferation and activate β-catenin signaling, which in turn enhances hair shaft elongation in ex vivo cultured human hair follicles, suggesting their potential use for alopecia treatment.

This study analyzed animal hairs from 18th-century burial sites in Mazamet, France, reporting distinct hair morphologies consistent with the use of common local animal furs such as goat, badger, cow, or horse, reflecting the modest socioeconomic status of the individuals interred.

This study used a 3D live imaging system to map cell dynamics in human hair follicles, revealing patterns of cell movement and division that help explain hair fiber extrusion during hair growth.