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Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

New genes and pathways are important for testosterone production and male sexual development.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

Retinoids are effective for various skin conditions and hair loss but have serious side effects, so low doses are recommended.

Hair in mammals likely evolved from glandular structures, not scales.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Excess androgens may cause PCOS, not just be a symptom.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Vitamin A is important for healthy skin and hair, influencing hair growth and skin healing, but UV light reduces its levels.

Eating too much or too little vitamin A can cause hair loss.