101 citations
,
May 2014 in “PLOS ONE” This study found that women with polycystic ovary syndrome have an increased risk of developing depressive disorder, anxiety disorder, and sleep disorder compared to those without the syndrome.
30 citations
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September 2016 in “BMJ” This study found that 5-α reductase inhibitors do not significantly increase the risk of erectile dysfunction in men with benign prostatic hyperplasia or alopecia, although duration of benign prostatic hyperplasia may elevate risk.
26 citations
,
December 2023 in “Prostate International” This review provides an overview of the risks and side effects associated with common medications used to treat benign prostatic hyperplasia, highlighting the importance for clinicians and patients to discuss these aspects for informed decision-making.
25 citations
,
September 2024 in “Cardiovascular Drugs and Therapy” This study found that while glucagon-like peptide 1 receptor agonists report more incidents of suicide, hair loss, and aspiration compared to some other antidiabetic drugs, they did not meet the threshold for positive safety signals.
20 citations
,
November 2019 in “International Journal of Environmental Research and Public Health” This study found that high exposure to air pollutants like SO2, NO, NO2, NOx, and PM2.5 was linked to a significantly increased risk of developing PCOS in women.
14 citations
,
December 2022 in “Frontiers in Pharmacology” This study reports that negative pressure wound therapy combined with PRP may effectively accelerate wound healing and reduce mortality in diabetic foot ulcers, with albumin and age identified as independent predictors of mortality risk.
13 citations
,
April 2019 in “Seizure” This review found that valproic acid treatment significantly increases the risk of alopecia compared to other drugs, regardless of dose or treatment duration.
12 citations
,
August 2017 in “Pharmaceutical medicine” This study found that physician knowledge of thromboembolism risk associated with cyproterone acetate/ethinylestradiol was generally high, although it varied for complex or less common topics.
8 citations
,
May 2024 in “Journal of Medical Virology” This study found that SARS-CoV-2 infection was associated with an increased long-term risk of developing alopecia areata in a large bi-national cohort from South Korea and Japan.
7 citations
,
October 2020 in “Dermatology practical & conceptual” This review discusses the potential risks associated with skin, hair, and nail supplements, highlighting concerns about safety, efficacy, and lack of regulation but reports no new clinical results.
7 citations
,
April 2021 in “Journal of Clinical Psychopharmacology” In this study, finasteride treatment was associated with an increased risk of depression, suicidal ideation, and persistent sexual dysfunction compared to those not treated with the drug.
4 citations
,
February 2004 in “Journal of Clinical Gastroenterology” Finasteride doesn't raise acute pancreatitis risk.
2 citations
,
July 2018 in “Risks” This study suggests that investing in a longevity megafund can significantly reduce longevity risk for pension funds, as it aligns financial returns with longevity and lowers associated economic capital needs.
2 citations
,
May 2017 in “International journal of pharmacy and pharmaceutical sciences/International Journal of Pharmacy and Pharmaceutical Sciences” This review discusses genetic mutations associated with Hutchinson-Gilford progeria syndrome and reports no clinical results; the authors emphasize the importance of cardiovascular monitoring in management.
1 citations
,
July 2010 in “PubMed” 1 citations
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January 2025 in “Dermatologic Therapy” This study analyzed FAERS data to explore the risk and onset patterns of autoimmune skin diseases associated with immune checkpoint inhibitors, finding a strong association particularly with bullous pemphigoid and emphasizing the need for vigilant monitoring of these adverse effects.
1 citations
,
August 2017 in “International clinical psychopharmacology” This study found that bupropion was associated with a higher risk of hair loss compared to other antidepressants, with paroxetine presenting the lowest risk.
June 2026 in “Pharmaceuticals” This study found that while 5α-reductase inhibitors like finasteride had many serious, unresolved adverse drug reactions, some were not listed in the existing product information.
November 2025 in “Toxicology Communications” The study observed that topical minoxidil poses an increasing and potentially deadly risk to pets, particularly cats, highlighting the urgent need for better public education and product labeling.
April 2021 in “Arab Journal of Nuclear Sciences and Applications/Arab Journal of Nuclear Sciences and Applications ” This study found that repeated use of a protein hair conditioner, followed by hot air and gamma irradiation, may lower serum collagen I and increase heat shock protein concentrations in rats, suggesting potential cumulative risks.
January 2026 in “Yonsei Medical Journal” Finasteride and dutasteride have little effect on Type 2 Diabetes risk.
October 2025 in “Dermatology Practical & Conceptual” This source highlights the potential benefits of identifying risk factors and intervening early to mitigate acne scarring and improve quality of life. It also emphasizes the importance of recognizing acne severity predictors to guide preventive strategies and optimize patient outcomes.
August 2025 in “The Journal of Sexual Medicine” This retrospective pharmacovigilance study identified 34 drugs, including finasteride and dutasteride, that may be associated with sexual dysfunction, with a higher risk observed in males aged 31-45.
February 2025 in “Journal of Pre-Clinical and Clinical Research” This source reports that combining 5-alpha reductase inhibitors with minoxidil for treating male androgenic alopecia presents a minimal risk of side effects when administered following established medical guidelines, with finasteride commonly associated with reversible sexual side effects and dutasteride used off-label with similar risks.
January 2025 in “Heliyon” This study found no significant difference in the risk of poor glycemic control between men with type 2 diabetes using tamsulosin and those using finasteride.
August 2024 in “Research Square (Research Square)” This study found that women taking 5α-reductase inhibitors (5aRI) for alopecia had a lower risk of breast cancer compared to those not using these medications, with no increased risk of developing ovarian or endometrial cancer.
April 2024 in “Public health” In this study of non-hospitalized patients in Dubai, pre-COVID vaccination and treatments with favipiravir or sotrovimab were associated with a reduced risk of developing long COVID.
March 2024 in “PLoS medicine” This study systematically reviewed meta-analyses and Mendelian randomization studies to identify factors influencing prostate cancer risk, finding suggestive associations for physical activity, height, and smoking but no robust, convincing overlapping evidence across tested factors.
This review examines the potential bidirectional relationship between polycystic ovary syndrome and periodontal diseases, but reports no new clinical findings; the authors suggest further research with larger sample sizes is needed to clarify the link.
August 2017 in “Journal of Pharmacy Practice and Research” This study details a method for assessing the risk of modifications to pharmaceutical frame formulations by assigning a risk priority number using Failure Modes Effects Analysis, which estimates the severity and probability of changes impacting the formulation.