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This study found that conditioned media from human amniotic fluid-derived stem cells may enhance skin regeneration by promoting cell proliferation and migration, and by modulating gene expressions altered by UV irradiation.

This review discusses how functionalized hydrogels can modulate the microbiome to aid tissue regeneration and infection control, highlighting their potential to deliver therapeutic agents effectively and support beneficial immune responses.

This study found that using uniform poly(lactic-co-glycolic) acid microspheres to deliver insulin-like growth factor 1 stabilizes the protein and enhances its sustained delivery, supporting stem cell functions comparably to traditional methods, and showing potential for tissue and organ regeneration.

In this study, a subcutaneous injection of recombinant RSPO1 was found to activate hair follicle stem cells and enhance hair regeneration in mice by stimulating the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for hair loss.

This study found that CLD-hFGF2 hydrogels improved healing in deep second-degree burn wounds more effectively than hydrogels alone or direct administration of CLD-hFGF2.

In this study, small molecule-loaded silk fibroin nanofiber scaffolds with chitosan achieved sustained release of GSK-3 inhibitor SB216763, leading to enhanced wound healing and hair follicle neogenesis in skin regeneration efforts.

In this study, Flii overexpression in mice enhanced fingertip regeneration and nail formation after both distal and proximal amputations, suggesting a role in digit and hair follicle regeneration possibly involving Wnt signaling.

This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.

This study found that IL-1α promotes hair follicle regeneration and stem cell activation in an age-dependent manner by modulating inflammatory cells and oxidative stress in mice.

This study developed microfluidic-assisted GelMA-MSC/HAD-EPC microspheres that efficiently generated hair follicles in nude mice, suggesting a promising strategy for advancing hair-regenerative medicine.

This review discusses the potential of adipose-derived stem cell extracellular vesicles (ADSC-EVs) in skin regeneration, highlighting mechanisms like inflammation and angiogenesis, but reports no new clinical results; challenges and future prospects are also considered.

This article reviews skin regeneration and fibrosis, identifying key cellular and molecular players, and emphasizing the potential to manipulate the postwound environment to promote regeneration over fibrosis.

This case report describes an 80-year-old patient whose scalp wound healed by secondary intention, with unexpected hair regrowth observed at 180 days, suggesting hair neogenesis is possible even in older adults.

This review highlights surprising similarities between hair follicles and antler units, suggesting that a comparative study of their biology could benefit understanding in both areas without presenting new empirical findings.

This review discusses cell membrane-coated scaffolds in tissue engineering, emphasizing their potential to enhance therapeutic outcomes in regenerative medicine and reporting no new experimental results.

This review examines diverse regenerative strategies in animals and highlights how biochemical, immunological, and mechanical signals can work together for successful skin regeneration in adult mammals, but it reports no new experimental results.

This study observed that deleting PTEN in mouse facial motoneurons enhanced peripheral axon regeneration but also led to physiological changes and potential hyperplasia in older mice.

This study identified ten key hub genes and pathways crucial for understanding the molecular mechanism of hair growth by comparing dermal papilla cells in 2D and 3D cultures.

This study reports that mesenchymal stem cell-conditioned medium promoted dermal cell migration and proliferation, enhancing wound healing but not direct hair growth, in vitro and in adult mouse models.

This protocol describes a method for regenerating hair follicles using a bioengineering technique called the Organ Germ Method, but it reports no new clinical results.

This study introduces a method using lentiviral delivery in mice to expedite analysis of factors crucial for hair follicle morphogenesis by enabling rapid gain- or loss-of-function studies.

In this mouse study, researchers reported that sequential monopolar-bipolar radiofrequency irradiation significantly improved skin quality by increasing collagen density, elastin fiber expression, and fibroblast differentiation more than monopolar RF treatment alone.

This study summarizes the signaling molecules and extracellular components involved in epithelial–mesenchymal interactions, enhancing our understanding of hair follicle regeneration and skin wound healing, but reports no new experimental results.

This study found that exosomes derived from bovine colostrum promoted hair growth in mice by activating the Wnt/β-catenin pathway, with effects similar to minoxidil but without adverse effects.

In this study involving adult mice, the researchers identified that double-stranded RNA-mediated activation of toll-like receptor 3 stimulates wound-induced hair neogenesis, potentially reflecting mechanisms used in facial rejuvenation treatments.

In this study, researchers developed a relatively simple punch assay for regenerating hair follicles using mouse or human cells, finding efficient hair formation with mouse cells but low efficiency with human cells on reconstituted human skin.

This review highlights advancements in 3D bioprinting for skin tissue engineering, focusing on exosome-loaded bioinks that show potential for enhancing skin regeneration and repair.

This review discusses the role of multiomics in understanding skin repair and regeneration mechanisms and reports no new results; the authors suggest it may lead to personalized medicine advancements and improved treatments.

In this study on C57BL/6 mice, researchers found that cadmium chloride exposure led to metabolic disruption, accelerated skin aging, and impaired hair regeneration, with more severe effects observed at higher doses.

This study found that epidermal stem cells in live mice exhibit coordinated intercellular Ca 2+ signaling governed by G2 cycling stem cells and mediated by Connexin43, essential for tissue-wide communication during regeneration.