Chemicals and stem cells combined have advanced regenerative medicine with few safety concerns, focusing on improving techniques and treatment effectiveness.
March 2014 in “Institutional Repositories DataBase (IRDB)” Skin-derived stem cells could help treat skin aging and pigmentation issues.
This study found that mouse type II spiral ganglion neurites in vitro avoided laminin and high concentrations of fibronectin, indicating both can guide neurite paths differently than type I neurites.
November 2009 in “Medical & surgical dermatology” This study found that haploinsufficiency of SPINK5 can lead to Netherton syndrome when a single null mutation combines with homozygous G1258A polymorphisms, suggesting it acts as a genuine mutation affecting LEKTI function.
This review discusses cyclosporine A's mechanisms of action and side effects compared to tacrolimus in renal transplantation, but it reports no new experimental results; the authors highlight implications for cardiovascular risk management.
291 citations
,
April 2010 in “Gastroenterology” This study identified Lgr5 and Lgr6 as receptors expressed by small populations of stem cells in various adult organs, with Lgr5+ve cells forming long-lived organoids in certain mouse models.
74 citations
,
January 2020 in “IEEE Access” This study reports that the ScalpEye system accurately diagnosed dandruff, folliculitis, hair loss, and oily hair with a precision range of 97.41% to 99.09%.
65 citations
,
April 2021 in “Natural Products and Bioprospecting” This review discusses the traditional uses and pharmacologically active compounds of 22 Dendrobium species for dermatological disorders but reports no new results, highlighting the need for further research.
64 citations
,
August 2007 in “Artificial Organs” This study found that PHBV cocultured with epithelial and dermal cells might enhance early-stage wound healing by promoting wound closure and re-epithelization more effectively than PHBV/collagen.
64 citations
,
May 2003 in “Journal of health psychology” This study found that women with PCOS reported higher overall psychological distress, but there was no significant link between their perceived hirsutism and this distress.
57 citations
,
May 2014 in “Molecular Phylogenetics and Evolution” This study utilized a sequence-structure alignment approach to improve the characterization of Class A Rhodopsin GPCR superfamily, including orphan and unclassified receptors, through evolutionary analysis.
55 citations
,
March 2012 in “Journal of Investigative Dermatology” Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.
51 citations
,
January 2006 in “Wound Repair and Regeneration” This study found that MRL/MpJ mouse dorsal skin wounds heal with similar scar formation and collagen deposition as C57bl/6 and Balb/c mice.
40 citations
,
December 2019 in “Neurobiology of Stress” This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.
27 citations
,
April 2011 in “International journal of legal medicine” This study reports that the completeness of DNA degradation in hair during cornification varies among individuals and affects the success rates of forensic hair DNA analysis.
24 citations
,
December 2009 in “Future Medicinal Chemistry” This study identified new potential targets and indications for several marketed drugs using in silico profiling, suggesting opportunities for drug repositioning.
22 citations
,
November 2024 in “Planta” This review highlights the potential of aromatic plants as natural antioxidants in cosmeceuticals, which may combat skin aging and promote rejuvenation by counteracting oxidative stress, offering a natural alternative to synthetic products with benefits like photoprotection and anti-wrinkle effects.
21 citations
,
April 2012 in “European Journal of Pharmaceutics and Biopharmaceutics” This study suggests that gel containing OSF3 loaded in niosomes offers high transfollicular penetration for topical anti-androgenic alopecia treatment with minimal systemic effect.
16 citations
,
July 2016 in “Veterinary Dermatology” This study found that dermoscopy can identify distinctive features in canine pattern alopecia, such as hair shaft thinning and pigmentation patterns, which may aid in diagnosing this and potentially other skin disorders.
15 citations
,
August 2013 in “Stem Cells and Development” This study proposes a two-step method that may enhance the generation of stem-like epidermal cells with superior proliferation and differentiation potential for skin regeneration.
14 citations
,
May 2019 in “Experimental Dermatology” In this study, adipose tissue secretome was shown to enhance oxidative stress resistance and promote cell proliferation in vitiligo cells, suggesting a potential natural treatment approach.
9 citations
,
July 2021 in “Journal of Natural Medicines” This review summarizes research finding over 150 new molecules with various biological activities from traditional herbal medicines studied in China, Mongolia, Uzbekistan, and Bangladesh.
9 citations
,
June 2020 in “Tissue Engineering and Regenerative Medicine” This study found that applying HHORSC exosomes may enhance the hair inductivity of dermal papilla cells, potentially improving treatments for hair loss.
April 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identified a specific genetic variant in the CCHCR1 gene that may contribute to alopecia areata through impaired keratinization, suggesting an alternative mechanism beyond autoimmune causes.
This study suggests that dermoscopy provides additional insights for diagnosing pattern alopecia in short coated dogs, beyond what is visible through standard dermatological examination.
97 citations
,
October 2019 in “Journal of Translational Medicine” This review discusses the use of very low-calorie ketogenic diets for obesity management and provides recommendations for nutrition experts, but reports no new clinical results.
14 citations
,
May 2021 in “Marine Drugs” This review discusses the therapeutic properties of polydeoxyribonucleotides derived from marine organisms for wound healing and inflammation, but it reports no new clinical results.
12 citations
,
September 2021 in “The International Journal of Developmental Biology” This review updates on the development of liposomal carriers for delivering growth factors to improve tissue regeneration and highlights recent efforts to enhance their stability and retention in tissues.
10 citations
,
September 2020 in “Computational and Mathematical Methods in Medicine” This paper introduces an algorithm for using smart device-mounted microscopes to analyze scalp images and diagnose hair loss by extracting specific hair loss features.
8 citations
,
August 2020 in “PLOS Computational Biology” This study presents a computational approach, CATNIP, which repurposes drugs using only their biological and chemical information, predicting new uses like adrenergic uptake inhibitors for Parkinson's and vandetanib for Type 2 Diabetes.