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The Rotterdam Study investigates diseases in older adults and has produced many research findings.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Rosacea is a skin condition with unclear causes, classified into four subtypes.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Targeting colon cancer stem cells might lead to better treatment results.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

The guidelines suggest lifestyle changes, diet adjustments, and personalized medication to manage dyslipidemia and reduce heart disease risk.

Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

The guide recommends specific methods for diagnosing PCOS and various treatments for its symptoms, while considering the health impacts on adolescents.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

Videodermoscopy improves diagnosis of hair and scalp disorders and may reduce scalp biopsies.

Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

The document likely offers guidance on treating a woman's excessive hair growth, considering her symptoms and obesity.