Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses the interplay between signaling/transcription factor-mediated and epigenetic mechanisms in skin development and regeneration, highlighting the need for further exploration of epigenome reorganization in these processes.

Certain hairstyles can cause scalp diseases, smoking is linked to hair loss, 5% minoxidil foam is effective for hair loss treatment, and various factors influence wound healing and hair growth.

This review discusses the roles of the hairless (HR) protein as a corepressor, particularly its impact on RORα-mediated transcriptional repression, and reports no new experimental findings.

This study reports that the differential expression patterns of three retinaldehyde dehydrogenases suggest a regulated need for retinoic acid synthesis in various organs during late mouse organogenesis.

This research suggests that defects in keratinocyte differentiation due to putrescine accumulation in SSAT transgenic mice lead to skin changes and hair loss, and reducing putrescine can promote hair regrowth.

This review discusses the role of microRNAs in skin function and potential therapeutic applications, emphasizing their importance in wound healing and disease management, though it reports no new experimental findings.

This review discusses the regulation and dynamics of the Wnt/β-catenin signaling pathway in development, pluripotency, and cancer, highlighting potential mechanisms and future research directions, but reports no new results.

This study found that disrupting Lm332 expression in mice changes keratinocyte genetic expression, alters cell shape, and disrupts epidermal homeostasis, despite some compensatory anchorage by hair follicle basal cells.

The researchers reported that autophagy, a lysosome-dependent degradation mechanism, plays a significant role in the cellular remodeling of keratinocyte differentiation in the skin, affecting the properties of the differentiation products by altering cellular components during this process.

This study found no significant differences in lectinhistochemical characteristics of the dorsal skin epidermis between hypotrichotic WBN/Ila-Ht rats and Wistar rats, except for varying lectin binding intensity.

This research observed that translation initiation shifts from cap-dependent to IRES-mediated pathways varied across tissues and cell types under stress and differentiation conditions in mice, with low IRES/Cap ratios signaling high stemness and potential multipotency, mediated by the RNA processing protein PTBP1.

In this study, researchers discovered that the MafB gene, which is important for macrophage differentiation, shows high expression in the pancreas and is influenced by sex steroids, with varied expression patterns in hamster tissues and during reproductive phases.

This review discusses recent insights into the dynamics and regulation of the epidermal differentiation complex during keratinocyte differentiation and reports no new experimental results.

This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.

This paper discusses the hypothesis that anti-acne agents may work by reducing FGFR2 signaling, and emphasizes FGFR2's potential role in acne pathogenesis, but it reports no new experimental findings.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

This analysis suggests that platelet-rich plasma therapy may be promising for treating androgenetic alopecia, but further controlled trials with standardized measures are needed to confirm its efficacy.

This study found that transcription factors HOXC13, LEF1, and FOXN1 repress DSG4 transcription, with the Notch pathway possibly involved in maintaining DSG4 expression in hair follicles.

This study identified the Hairless (Hr) gene-encoded protein as a corepressor that plays a crucial role in maintaining skin and hair by regulating epithelial stem cell differentiation and gene expression via chromatin remodeling, which may impact both development and disease.

This review discusses changes in keratin structure or gene expression that result in various skin disorders and reports no new clinical findings.

This study suggests that vitamin D-upregulated protein 1 (VDUP1) might play a unique role in regulating the differentiation of epidermal cells.

The researchers found that HOXC13 regulates different keratin proteins in a mixed manner, with certain SNPs impeding this regulation, while also demonstrating negative-feedback by HOXC13 and positive regulation by LEF1 and melatonin on the HOXC13 promoter.

This study indicates that targeting the PTH/PTHrP receptor may potentially stimulate hair growth, particularly for chemotherapy-induced alopecia, as observed in hairless and cyclophosphamide-treated mice.

This study found that suspension culture was more effective than hydrogel-based systems for maintaining spheroid morphology and differentiation of human iPSC-derived definitive endoderm cells.

This article reviews mammalian skin epidermis as a model for studying stem cell regulation, noting the utility of in vitro and ex vivo platforms, but it reports no new empirical findings.

This review discusses current knowledge of keratinocyte stem cell dynamics, including their regenerative roles and potential applications beyond wound healing, but presents no new clinical findings.

This study identified a genetic locus associated with rhabdomyosarcoma susceptibility in mice and found that specific differentiation markers are linked to the regression of basal cell carcinoma.

This study found that polycomb-group-mediated repression plays a key role in regulating hair follicle stem cell states and lineage progression by distinct mechanisms in adult mouse skin.

This review explores the role of TGF-β superfamily pathways in stem cell environments and their implications for tissue regeneration and cancer development, reporting no new experimental results.

This review discusses the roles of TGF-β family signaling in regulating normal and cancer stem cells and highlights the need for further research to develop potential cancer treatments; it reports no new results.