August 2019 in “Stem cells” This paper reviews the role of miRNAs in stem cell therapies and hair follicle growth, reporting no new findings but highlighting recent insights into fertility treatment and wound healing.
June 2014 in “Basic & Clinical Pharmacology & Toxicology” This study found that alkaloids isolated from Cucumis metuliferus fruit pulp demonstrated antiviral activity against IBDV in chicken embryo fibroblast cells and NDV in 10-day-old embryonated chicken eggs, while being non-cytotoxic.
August 2012 in “Pharmaceutical Medicine” The document concludes that various medications and treatments can have significant, sometimes adverse, effects on health outcomes.
May 2011 in “Psychiatric News” This article provides regulatory updates, legal briefs, and industry news, reporting no new clinical findings.
This case study reports that prolonged high-dose vitamin A intake led to multiple adverse health effects in a young man, which mostly resolved after stopping the supplement, although liver changes persisted.
April 1978 in “Pediatric research” This study found that zinc levels in hospitalized patients with significant weight loss did not correlate with taste perception or vitamin A status, even in those with reduced taste acuity.
93 citations
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October 2006 in “The International Journal of Biochemistry & Cell Biology” This review discusses melanocyte biology and its genetic and molecular basis, highlighting its relevance in understanding diseases like vitiligo and albinism, and reports no new findings.
6 citations
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February 2004 in “Clinical and Experimental Ophthalmology” This case report indicates that retinoblastoma can occur in a microphthalmic eye and recommends using multiple imaging techniques due to potential differences in calcification visibility.
5 citations
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February 2004 in “Clinical and Experimental Ophthalmology” This study presents two cases correlating the clinical appearance of adult-onset foveomacular vitelliform dystrophy with optical coherence tomography findings, describing the location of the yellow vitelliform material.
59 citations
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January 2011 in “Retina-the Journal of Retinal and Vitreous Diseases” This study suggests that finasteride may be a promising treatment for chronic central serous chorioretinopathy, but larger controlled trials are needed to confirm its efficacy.
This study found that 4-(ethoxycarbophenyl) retinamide (RI) exhibited significantly lower acute, subacute, and chronic toxicity compared to other retinoids in mouse and rat models.
This article discusses tretinoin, noting its approved use for acne and photoaging and its broader application in treating various dermatological conditions, but reports no new clinical findings.
January 1988 in “Inpharma (Balgowlah)” New retinoids are effective for various skin conditions and are being developed to have fewer side effects.
6 citations
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December 1987 in “Mayo Clinic proceedings” This article reviews the use of retinoids, such as tretinoin, isotretinoin, and etretinate, in dermatological treatments, highlighting their efficacy and side effects, but presents no new clinical findings.
This article reviews different generations of synthetic retinoids for dermatological use, discussing their efficacy and significant side effects, but reports no new clinical results.
108 citations
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November 1980 in “British Journal of Dermatology” This article reviews the current status of oral retinoids in dermatology and reports no new clinical findings.
31 citations
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January 1981 in “Pharmacology & Therapeutics” In this study, 13-cis-5S*,8S*-epidioxy-5,8-dihydroretinoic acid was found to be significantly more cytotoxic to cancer cell lines than other retinoic acid analogs evaluated.
January 2023 in “Journal of cosmetic dermatology” This study found that the synthetic retinoid EC23 effectively induces keratinocyte hyperproliferation and enhances hair growth in mice, showing more potency than all-trans retinoic acid.
4 citations
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May 2018 in “Türk pediatri arşivi : İstanbul çocuk kliniği dergisi” This study reported dramatic improvements in five collodion baby patients with lamellar ichthyosis treated with oral retinoic acid, noting hair loss as the sole adverse effect, emphasizing the treatment's promising efficacy for physicians.
January 2017 in “Clinical approaches and procedures in cosmetic dermatology” This research outlines how retinoids, compounds based on vitamin A, activate nuclear receptors to influence cellular processes such as differentiation and carcinogenesis, with benefits like anti-inflammatory properties but requiring careful management of dose-dependent side effects.
44 citations
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May 1998 in “PubMed” In this study, a specific retinoic acid receptor antagonist caused severe craniofacial anomalies in mouse fetuses when administered early in pregnancy, but not limb anomalies, highlighting developmental stage-specific roles of retinoic acid.
January 1982 in “Side effects of drugs annual” This review discusses the therapeutic effects of vitamins, highlighting risks such as liver damage from prolonged high doses of vitamin A and hypercalcemia from excessive vitamin D, while noting a case of allergic reaction to vitamin B12.
53 citations
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October 1993 in “Drug Safety” Oral retinoids can cause side effects ranging from mild to severe, including birth defects, and require careful monitoring and contraception.
52 citations
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June 1981 in “International Journal of Dermatology” Oral retinoids are effective for severe skin conditions but require careful use due to side effects.
This article discusses variations in retinoid pharmacokinetics affecting their toxicity and clinical efficacy, but reports no new results; the authors emphasize considering toxicity in selecting suitable compounds.
January 1990 in “Irish Journal of Medical Science (1971 -)” Retinoids are important for treating skin conditions but should be used with caution due to serious side effects and risks during pregnancy.
75 citations
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August 2005 in “Expert Opinion on Pharmacotherapy” This review discusses the use of acitretin, a retinoid approved since 1997, for various forms of psoriasis and its potential benefits in combination therapy, but reports no new clinical findings.
June 2015 in “OhioLink ETD Center (Ohio Library and Information Network)” This study found that acute UVB exposure in mice increases the synthesis of retinoic acid in the epidermis, which is necessary for normal repair from UVB light.
36 citations
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July 2017 in “Journal of controlled release” In this study, a new formulation of all-trans retinoic acid bound to polyvinyl alcohol showed reduced skin inflammation and sustained drug release for up to six days compared to free ATRA in vitro and in vivo.
April 1982 in “Journal of The American Academy of Dermatology” Retinoids help treat psoriasis effectively, but they can cause side effects and need more research on safe use with other treatments.