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Researchers found key regions in the mouse hairless gene that control its activity in skin and brain cells, affecting hair follicle function.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Acne significantly affects mental health and quality of life, with research suggesting hormonal and genetic factors in its development and emphasizing early treatment to prevent scarring.

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

Researchers created early-stage hair-like structures from skin cells, showing how these cells can self-organize, but more is needed for complete hair growth.

Indigenous herbal medicines in the Indian subcontinent have potential for drug development but need more research and standardization.

Skin aging is caused by stem cell damage and can potentially be delayed with treatments like antioxidants and stem cell therapy.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Dermal-epidermal interactions are crucial for hair growth and maintenance.

Retinoids can prevent skin cancer in high-risk people but have side effects and require more research on dosing and effectiveness.

Researchers developed a method to measure drugs in hair follicles and found that both water-loving and fat-loving drugs can be detected after being applied to the skin.

Combining mometasone furoate cream with adapalene gel is safer and more effective for hair regrowth in alopecia areata than using the cream alone.

Researchers found a gene in hamsters that responds to male hormones and may be indirectly controlled by them.

Gray hair can potentially be reversed, leading to new treatments.

The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.

Women with idiopathic hirsutism and PCOS have higher RBP4 levels, and PCOS is linked to greater insulin resistance; weight management may help both conditions.

Lichen planus is a chronic autoimmune disease that is hard to treat and more common in women.

Proretinal nanoparticles are a safe and effective way to deliver retinal to the skin.

Acne vulgaris is a common skin condition that can cause low self-esteem and depression, and early treatment is important to prevent scarring.

Sleep problems and skin issues affect each other; poor sleep can worsen skin conditions, and some skin treatments can improve or harm sleep quality.

A patient experienced long-lasting hair loss after using acitretin for psoriasis.

Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.

Eating too much or too little vitamin A can cause hair loss.