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Activating NRF2 might help treat hair disorders by improving antioxidant defenses.

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

Some skin conditions are common during pregnancy and can be safely treated without affecting the pregnancy outcome.

Monotreme hair structure and protein distribution are similar to other mammals, but their inner root sheath cornifies differently, suggesting a unique evolution from reptile skin.

Alopecia areata causes hair loss due to an immune attack on hair follicles, influenced by genetics and environment.

Testosterone therapy may improve mood, well-being, and sexual function in premenopausal women, but more research is needed on its long-term safety and effectiveness.

PGF_2α receptors in human eyelids are found in specific parts of hair follicles, explaining eyelash changes with glaucoma treatment.

Beige and leaden pigment genes act within melanocytes, affecting pigment patterns.

Caspase-7 has functions in skin and hair that are not related to cell death.

Pig skin cells can turn into mesodermal cells but lose their ability to become neural cells.

Hormones affect skin aging, and treatments targeting hormonal balance may improve skin health.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Hair grays due to oxidative stress and fewer functioning melanocytes.

PRP more effective than minoxidil 5% for treating alopecia areata.

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.

Hair loss in males involves inflammation, collagen buildup, and follicle damage, with severity increasing with age and baldness duration.

Testosterone therapy may slightly improve sexual function in postmenopausal women, but its long-term safety is unknown.

Oral retinoids are effective for treating severe skin disorders but have reversible side effects and risks for pregnant women.