54 citations
,
January 2013 in “BMC Complementary and Alternative Medicine” In this study, topical application of Thuja orientalis extract promoted hair growth by inducing the anagen phase and increasing hair follicle size and number in telogenic mice.
53 citations
,
April 1985 in “Developmental Biology” Fibronectin and other basement membrane components increase during hair growth and decrease during rest.
50 citations
,
August 1999 in “Experimental dermatology” This review discusses the need for more research on how the chronobiological control systems regulate hair follicle cycling and reports no new results.
13 citations
,
June 2020 in “BMC genomics” This study found that chi-miR-30b-5p was more expressed in the telogen phase than in the anagen phase and inhibited dermal papilla cell proliferation by targeting CaMKIIδ.
5 citations
,
December 2018 in “Biological & Pharmaceutical Bulletin” In this study, norgalanthamine was found to stimulate hair growth in cultured rat dermal papilla cells by activating the ERK 1/2, PI3K/AKT, and Wnt/β-catenin signaling pathways.
5 citations
,
August 2015 in “Bioscience, Biotechnology, and Biochemistry” In this study, ob/ob mice were found to have a prolonged telogen hair cycle phase from 10 to 24 weeks, suggesting their potential as a model for studying telogen effluvium.
3 citations
,
January 2003 This study found that SPELA 707, a herbal extract mixture, enhanced hair density and promoted hair growth by converting hair into the anagen phase in individuals with androgenetic alopecia and C3H mice.
1 citations
,
January 2023 in “Journal of Clinical Medicine” This study reported that Tomorrowlabs HIF strengthening factor [HSF] hair restoration technology significantly improved hair thickness, density, shine, and elasticity, while reducing hair loss by an average of 66.8% and enhancing hair growth by up to 32.5% in subjects with androgenic alopecia over nine months.
April 2024 in “Clinical, cosmetic and investigational dermatology” This study found that salvianolic acid B significantly enhanced hair growth and delayed hair follicle cycle progression in mice and human hair models, suggesting potential as a treatment for hair loss.
October 2023 in “Peer review” This review discusses the efficacy and safety of using intradermotherapy combined with platelet-rich plasma for treating alopecia and reports no new clinical results.
May 2023 in “Journal of Investigative Dermatology” In this study, researchers found that topical application of the diabetes medication Sitagliptin in mice accelerates hair follicle regeneration and reduces fibrosis, suggesting it could be repurposed to treat hair loss conditions like alopecia.
August 2022 in “Gene Reports” This review discusses androgenetic alopecia and alopecia areata through a systems biology perspective using omics technologies to explore molecular mechanisms and potential personalized therapies, and it reports no new clinical results.
January 2018 in “Springer eBooks” Telogen Effluvium causes more hair loss because hair moves to the resting phase too soon.
April 2010 in “PubMed Central” This abstract discusses the FDA approval of Latisse (bimatoprost) for increasing eyelash growth in patients with eyelash hypotrichosis and highlights its efficacy while noting unresolved effectiveness in certain conditions and potential side effects.
20 citations
,
January 1995 in “Cells tissues organs” The researchers reported that exposure to long days after short-day treatment induced a synchronized, out-of-season wool growth cycle in New Zealand Wiltshire sheep, similar to cycles induced in other species.
5 citations
,
January 2018 in “Italian journal of dermatology and venereology” This study discusses that while the precise mechanism of minoxidil is not fully understood, its efficacy in stimulating hair growth and treating androgenetic alopecia is well-supported, with evidence showing it increases hair count and hair follicle size in treated patients.
82 citations
,
March 2012 in “Development” This study found that deleting the miRNA processing enzymes Drosha and Dicer from mouse skin epithelial cells disrupted normal hair follicle development and maintenance, leading to follicular degradation and stem cell loss during the growth phase.
10 citations
,
January 2009 in “Elsevier eBooks” This review discusses the structure, functions, and growth cycle of human hair, emphasizing its reduced growth and protective roles, and reports no new research findings.
9 citations
,
April 2019 in “International journal of molecular sciences” In this study, growing human hair follicles in a defined glycosaminoglycan hydrogel ex vivo promoted cell survival, proliferation, and activation of hair growth-related signaling pathways, suggesting GAG-based hydrogels could modulate the hair follicle growth cycle.
1 citations
,
June 2017 in “Nature Reviews Immunology” Immune cells called Treg cells are essential for hair growth and regeneration.
2 citations
,
January 2015 in “BioMed Research International” This article reviews various aspects of growth factor research, highlighting their role in treatments and emphasizing the need for further clinical trials to validate their efficacy in biomedical applications.
September 2022 in “Journal of Cosmetic Dermatology” Hair casts may be a useful clue for diagnosing hair loss during the resting phase of hair growth.
April 2016 in “Journal of Investigative Dermatology” This study found that inhibiting JAK signaling can unexpectedly trigger hair growth in resting-phase mouse skin, implicating JAK-STAT pathways and oncostatin M in maintaining hair follicle stem cell quiescence.
77 citations
,
July 2012 in “Journal of Investigative Dermatology” The researchers observed that overexpression of Wnt10b in a mouse model can induce hair follicle regeneration by switching follicles from the resting phase to the growth phase via the Wnt-β-catenin signaling pathway.
January 2013 in “Вестник Томского государственного университета. История” This study suggests that the presence of vellus hairs and empty spaces in prepubertal scalps may reflect a natural resting phase of hair growth rather than indicating early androgenetic alopecia.
113 citations
,
September 2005 in “Journal of Investigative Dermatology” This study found that a topical hedgehog agonist can stimulate hair growth by promoting the transition from the resting to growth phase of the hair cycle in adult mouse skin.
October 2005 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that induced TERT expression in mouse skin epithelium rapidly transitions hair growth from the resting to active phase by promoting stem cell proliferation through a non-telomere related mechanism.
December 2023 in “Journal of Food Science and Nutrition” In this animal study, rosehip seed oil applied to the skin of mice promoted hair regrowth by accelerating hair follicles' transition from resting to growth phases and increased hair follicle density, bulb size, and skin thickness, suggesting potential as a treatment for hair loss.
This study found that ocu-miR-205 promotes the apoptosis of dermal papilla cells and the transformation of hair follicles from growth to regression and resting phases in Rex rabbits.
April 2018 in “Journal of Investigative Dermatology” This study identified a specific subset of macrophages as a key source of oncostatin M, maintaining hair follicle stem cell quiescence during the resting phase in mice, suggesting a potential target for treating hair disorders.