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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

The same hormone can affect gene expression differently in various tissues, which could lead to new treatments for conditions like hair loss.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Selenium can be toxic to animals, causing serious health issues, especially in horses.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Chromosomal differences affect how muscle cells respond to testosterone.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Riboflavin 5′-phosphate (FMN) shows potential for treating androgen-related conditions but may be limited in treating prostate cancer.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

New treatments for low male hormones improved sexual function and mood but had unclear risks, especially for older men.

MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.

Lespedeza cuneata extract may help treat enlarged prostate.

Saw palmetto in hair products might reduce hair loss but can cause side effects.

Hormonal imbalances can cause skin and hair problems in women, and treatments that block male hormones can help.

Cell transplantation faces challenges in genitourinary reconstruction, but alternative tissue sources and microencapsulation show promise.

The review suggests new ways to classify ejaculation problems and recommends different treatments based on the type of issue.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Triptorelin helps evaluate hormone production in Sertoli-Leydig cell tumors.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

Testosterone therapy can help improve mood, sexual function, and bone health in women with low androgen levels, but more research is needed to establish safe and effective guidelines.

Age affects how certain proteins involved in COVID-19 infection are expressed in mice, but sex hormones and heart injury do not.

Recognizing specific skin features helps diagnose and manage lupus erythematosus effectively.

PRP helps skin heal, possibly through special cells called telocytes.

Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.

We need better ways to test and understand SARMs to make safer and more effective treatments.