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Histamine plays key roles in immune responses, stomach acid, and brain signals.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

The human sebocyte culture model has improved understanding of oily skin and acne, and how they can be treated.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Pectin biosynthesis is essential for the growth of cotton fibers and Arabidopsis root hairs.

Melatonin helps regulate sleep and may aid in treating various health issues.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Wnt10b overexpression can regenerate hair follicles, possibly helping treat hair loss and alopecia.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

The conclusion is that Fgf18 and Tgf-ß signaling could be targeted for hair loss treatments.

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.

Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

Gray hair may be caused by lower antioxidant activity in hair cells.

GLI2 increases follistatin production in human skin cells.

Dietary lipids affect inflammation and are crucial for normal cell function and immune health.

Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.

Smad4 is important for healthy hair follicles because it helps produce a protein needed for hair to stick together and grow.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Phospholipase A2 enzymes play key roles in skin health and disease.

Colchicine can inhibit hair growth by affecting cell activity and protein expression in hair follicles.

Genes affect cytokine production, which can influence chronic diseases, and certain interventions may help prevent related molecular damage.

Immune cells around hair follicles help control hair growth and could be targets for treating hair disorders.

Different fields of expertise must work together to better understand hair growth and create effective hair loss treatments.

Use oral or enteral supplements when possible and reserve IV trace elements for those solely dependent on PN.

The protein p53 directly reduces the production of Keratin 17, a skin and hair protein, in rats with radiation dermatitis.

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

The document concludes that PK/PD modeling is important for determining the safe and effective dosages of drugs.