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In a testosterone-induced mouse model, this study found that exosomes from injectable Platelet-Rich Fibrin (i-PRF) significantly reduced inflammation, oxidative stress, and apoptosis, while enhancing hair regeneration, with the greatest improvements seen when combined with minoxidil, suggesting potential as a novel treatment for androgenetic alopecia.

This review examines androgenetic alopecia, detailing its causes and current treatments, but reports no new clinical results; the authors emphasize understanding its complexity for personalized therapy development.

This review synthesizes current knowledge on hair follicle biology in androgenetic alopecia and explores potential regenerative therapies, but it reports no new clinical results.

This narrative review explores molecular signaling pathways and their impact on hair follicle microenvironments in androgenetic alopecia, alongside potential treatments like stromal vascular fraction therapies and exosome-based strategies.

This review integrates current understanding of hair follicle biology and signaling pathways into a comprehensive framework for androgenetic alopecia, but presents no new empirical findings.

This laboratory study found that dendrobium officinale polysaccharide (DOP) stimulated hair follicle and hair growth in mice by activating the WNT signaling pathway.

This review summarizes existing knowledge of how the WNT signaling pathway affects mesenchymal stem cells under various conditions, highlighting challenges and mechanisms for clinical applications.

This study found that Shi-Bi-Man, a hair health supplement, significantly promoted hair growth in mice, likely through activation of the FGF signaling pathway.

This review discusses the dual role of the Wnt/β-catenin pathway in mammalian tissue injury, highlighting its potential for both promoting regeneration and contributing to fibrosis, but presents no new findings.

This review article analyzes the role of the WNT signaling pathway in skin development, wound healing, and mechanical stretching, emphasizing its importance in understanding and potentially advancing treatments for skin-related diseases.

This review highlights that T cells are crucial in regulating hair follicle regeneration and their disruption can lead to alopecia, providing insights into hair disorders related to T cell immune balance and hair follicle regeneration.

This study highlights emerging regenerative strategies, such as stem cell-derived therapies and machine learning tools, that may advance hair loss treatment beyond traditional methods by promoting follicle regeneration and offering personalized care.

This research observed that Moracin M, a compound from the Moraceae family, significantly promotes hair growth and angiogenesis via the Wnt signaling pathway in human dermal papilla cells, offering a promising alternative to current hair growth treatments like minoxidil.

In this review, the authors explore strategies for inducing scarless skin regeneration by modulating dermal signaling or specific fibroblast subsets to promote the formation of new hair follicles in wounds, particularly focusing on mimicking neonatal skin's regenerative capabilities.

This study found that manipulating both gene expression and matrix stiffness in mice can alter hair regeneration after skin wounding, highlighting key factors in regenerative biology.

This study found that dermal papilla cell-derived exosomes promote hair follicle regeneration during wound healing by enhancing fibroblast activity and activating the Wnt/β-catenin signaling pathway in mice.

This study demonstrated that blocking the Sonic hedgehog signaling pathway in mice led to reversible inhibition of body coat hair morphogenesis, while whisker development was unaffected.

This study found that liposterolic extracts of Serenoa repens enhanced hair regeneration and repair in DHT-induced hair loss mouse models, suggesting potential effects comparable to finasteride.

This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.

This review discusses the role of Wnt/β‐catenin signaling in stem and cancer stem cell maintenance and its involvement in the development and regeneration of various organs, but reports no new experimental results.

The researchers reported that topical application of small-molecule Wnt inhibitors significantly reduced fibrosis and promoted regenerative wound healing in mice.

This article introduces the concept of organ size control in regeneration, regulated by the Hippo signaling pathway, but reports no new experimental results.

In this study, a subcutaneous injection of recombinant RSPO1 was found to activate hair follicle stem cells and enhance hair regeneration in mice by stimulating the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for hair loss.

Tanshinone Capsule may help regrow hair by boosting specific cell signals.

This study found that naringin, a natural flavonoid, significantly improved hair growth in mice by activating the Wnt/β-catenin pathway, with the 4% concentration showing comparable efficacy to 5% minoxidil, suggesting naringin as a promising alternative for alopecia treatment.

This study found that melatonin supplementation significantly promoted hair regeneration in a hair depilation mouse model by up-regulating the Wnt/β-catenin signaling pathway in dermal papillae and hair follicle stem cells, suggesting potential implications for human hair loss treatments.

This study concluded that shikonin, a small molecule derived from herbal extract, promotes wound healing and reduces inflammation in mice by activating the PI3K/Akt signaling pathway.

This study concluded that controlled micro-injury induces hair regeneration and vitiligo repigmentation in mice, potentially through the Wnt/β-catenin pathway.

This study demonstrated that ellagic acid promoted hair regrowth in a DHT-induced androgenic alopecia mouse model by inhibiting ferroptosis through the activation of the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for androgenic alopecia.

This study observed that activating the Wnt/β-catenin pathway enhances hair follicle stem cell proliferation and differentiation, promoting hair growth and wound healing, and demonstrated the potential for outer root sheath transplants to aid skin repair, although challenges remain for clinical application.