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Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Fat cells in the skin help start healing and form important repair cells after injury.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

Applying a special compound can promote hair growth without harmful side effects.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Laminin-511 is crucial for early hair growth and maintaining important hair development signals.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

Thymosin β4 promotes hair growth by activating stem cells in hair follicles.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Wnt signaling helps control how brain stem cells divide and is important for brain repair after injury.

Fetal skin heals without scarring due to unique cells and processes not present in adult skin healing.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

MDP hydrogel heals wounds faster and better than other treatments in diabetic mice.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

NF-κB is crucial for zebrafish heart repair, affecting heart cell growth and repair processes.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.

Sponge helps heal wounds faster with less inflammation and better skin/hair growth.

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.