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Alopecia Areata is an autoimmune condition often starting before age 20, with varied treatment success and a need for personalized treatment plans.

Hidradenitis suppurativa is caused by genetic factors, inflammation, bacteria, hormones, and lifestyle factors like obesity and smoking.

Some common medications can harm male fertility, but many effects can be reversed.

Chemotherapy often causes skin, nail, and hair side effects, significantly impacting quality of life.

Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.

Minoxidil and finasteride are effective for male hair loss, minoxidil for female hair loss, and various treatments like corticosteroids work for alopecia areata; treatment should be tailored to the individual.

Toxic epidermal necrolysis is a severe skin condition often caused by drugs, with complex treatment and a high risk of death, but survivors usually heal without scars.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

The conclusion is that Fgf18 and Tgf-ß signaling could be targeted for hair loss treatments.

Inactive hair follicle stem cells help prevent skin cancer.

The hair follicle is a great model for research to improve hair growth treatments.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Neurosteroids show promise for treating epilepsy and more research is needed.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

Immunosuppressive and anti-TNF therapies in IBD patients can increase the risk of skin cancer and cause various skin issues.

Acne keloidalis nuchae is a tough-to-treat condition that greatly affects quality of life, especially in men of African descent.

Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.

Finasteride helps reduce heart issues and improves heart function.

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.

The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.

Cancer treatments often cause hair disorders, significantly affecting patients' quality of life, and better management methods are needed.

Botulinum toxin shows promise for various skin conditions but requires more research for confirmation and standardized use.

PRP injections improve hair density and thickness in women with hair loss.

Treating cystoid macular oedema in uveitis is difficult and risky.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.