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research Successful management of therapy-resistant chronic refractory atopic dermatitis and alopecia universalis with oral tofacitinib in a girl
In this case study, a 5-year-old girl with alopecia areata and atopic dermatitis that were unresponsive to previous treatments achieved substantial improvement with long-term tofacitinib, highlighting its potential safety and efficacy in managing both conditions concurrently.
research Refractory Alopecia Areata of the Beard: Novel Improvement Through Exosome Therapy With Signs of Hair Repigmentation
This study found that exosome injections from human umbilical cord, with or without polydeoxyribonucleotide, promoted regrowth and repigmentation of white beard hairs and improved scarring in a 35-year-old man with refractory alopecia areata, suggesting potential as a minimally invasive regenerative treatment.
research Adipose Tissue–Derived Exosomes as a Novel Therapeutic Approach for Refractory Alopecia Areata: A Report of Two Cases
In this study, two female patients with severe, treatment-resistant alopecia areata showed significant hair regrowth after a single session of intradermal administration of adipose tissue–derived exosomes, without experiencing adverse events, suggesting a promising therapeutic strategy for refractory cases.
research Unique Treatment for Alopecia Areata Combining Epinephrine With an Intralesional Steroid
This study reports two cases of severe alopecia areata showing seemingly permanent hair regrowth with a modified triamcinolone acetonide regimen involving epinephrine, and suggests a potential role for epinephrine in enhancing treatment efficacy.
research The Effect of JAK Inhibitor on the Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells
This study found that ruxolitinib modulated inflammatory changes and stimulated growth factor signals by blocking the JAK-STAT pathway in an in vitro model of alopecia areata.
research Utilizing Electromagnetic Radiation for Hair Growth
This review discusses the use of electromagnetic radiation, including low-level laser therapy, for hair loss management, but it reports no new clinical results and suggests further research.
research Remarkable Improvement of Nail Changes in Alopecia Areata Universalis with 10 Months of Treatment with Tofacitinib: A Case Report
In this study, tofacitinib treatment in a male patient with alopecia areata led to significant hair regrowth and improvement in nail dystrophy symptoms, restoring finger function within 10 months.
research 13. Wound Healing & Hair
Minoxidil may improve hair transplants and combining treatments could help alopecia areata.
research Leflunomide: an unlikely trigger and mechanistically a beneficial drug for alopecia areata
Leflunomide is more likely to help treat alopecia areata than cause it.
research Resting no more: re‐defining telogen, the maintenance stage of the hair growth cycle
This article explores the dynamic and energy-efficient nature of telogen hair follicles, challenging the notion of dormancy, and highlights their potential in advancing treatments for hair growth disorders.
research Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor
This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.
research Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology
This consensus concluded that oral isotretinoin is highly effective for treating acne and some off-label conditions, with common adverse events being manageable and rare serious risks not contraindicating use.
research Dermatologic Conditions in Transgender Populations
This review discusses skin diseases in transgender patients receiving gender-affirming hormone therapy and procedures, highlighting unique conditions and the underdiagnosis that affects their quality of life and mental health.
research Mechanical Fractionation of Adipose Tissue—A Scoping Review of Procedures to Obtain Stromal Vascular Fraction
This study reviewed the efficacy of mechanical fractionation techniques to produce tissue stromal vascular fraction (tSVF) and found that tSVF injections are particularly effective for conditions like osteoarthritis and wound healing, with centrifugation before fractionation improving isolation efficiency regardless of preparation method.
research Safety and Efficacy of Ritlecitinib for the Treatment of Patients with Alopecia Areata: A Systematic Review and Meta-Analysis of Controlled Trials
This study found that Ritlecitinib significantly reduced hair loss in patients with alopecia areata by lowering SALT scores at weeks 12 and 24 compared to placebo, with acceptable safety but increased minor side effects like headaches and acne.
research Alopecia areata
This review discusses various nail changes in alopecia areata and suggests that they may be more prevalent than previously recognized, impacting quality of life and potentially indicating disease progression.
research Quality of Life in Patients with Alopecia Areata presenting to the Department of Dermatology at a Tertiary Care Hospital of Lahore, Pakistan
This study found that patients with alopecia areata experience reduced quality of life, particularly among women and those with severe or long-lasting disease.
research Hair Growth in a Patient with Alopecia Areata on Tocilizumab
This case report describes a 21-year-old woman with progressive alopecia areata who experienced hair regrowth while treated with tocilizumab for posterior uveitis, suggesting the potential for this drug to affect hair loss and regrowth by disrupting interleukin-6 signaling.
research Clinical evidence for JAK inhibition in alopecia areata: A comprehensive review
JAK inhibitors effectively regrow hair in alopecia areata but hair loss often returns after stopping treatment.
research Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies
This literature review explores the role of biomarkers in personalized medicine for various dermatological conditions like Hidradenitis Suppurativa, Psoriasis, and Atopic Dermatitis, highlighting how they guide targeted therapies and the limitations of current markers in specificity, as reported by the authors.
research Abstracts
This review discusses autoimmune blistering diseases across species and highlights new treatment efficacy findings and ongoing trials, but it reports no new clinical results.
research Therapeutic management of hypothyrodism with concurrent babesiosis in a non-descript dog
This case report describes a 4-year-old dog successfully managed for primary hypothyroidism and concurrent Babesia gibsoni infection, treated with thyroxine, Diminazine aceturate, antibiotics, and supportive therapies, resulting in clinical improvement and negative blood smear for Babesia by day 30.
research A State-of-the-Art Overview on (Epi)Genomics and Personalized Skin Rejuvenating Strategies
This review highlights new perspectives in genomics and epigenomics for skin rejuvenation, comparing innovative strategies like senolytics and DNA repair modulators with classical treatments, and emphasizing the importance of tailoring therapies using individual genomic profiles for personalized anti-ageing approaches.
research Alisertib is active as single agent in recurrent atypical teratoid rhabdoid tumors in 4 children
In this study, four children with recurrent atypical teratoid rhabdoid tumors experienced disease stabilization or regression after treatment with alisertib, suggesting its potential role in future trials for this condition.
research North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations
This review provides graded evidence and a therapeutic algorithm for managing hidradenitis suppurativa, but does not present new clinical results.
research The non-neuronal and nonmuscular effects of botulinum toxin: an opportunity for a deadly molecule to treat disease in the skin and beyond
This review discusses the broadening scope of botulinum toxin applications beyond traditional uses, highlighting its effects on non-neuronal cells and potential in treating various dermatological conditions, without reporting new clinical findings.
research Life threatening macrophage activation syndrome as the initial presentation of systemic lupus erythematosus: A case report and review of the literature
This case report describes a rare instance where a young woman initially presented with macrophage activation syndrome as the first sign of systemic lupus erythematosus, and ultimately experienced multiorgan failure and death.
research Ophiasis alopecia areata treated with microneedling
This case report describes a 58-year-old man with ophiasis-pattern alopecia areata who showed significant hair regrowth after treatment with clobetasol and microneedling with triamcinolone.
research Ponatinib-induced pityriasis rubra pilaris-like adnexal dysmaturation: A case report
This study reported a rare case of pityriasis rubra pilaris-like skin reaction in an 18-year-old woman after starting ponatinib treatment for relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia, which resolved after treatment adjustment and did not recur over 15 months.