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This study found that elevated epidermal ODC activity in transgenic mice promotes skin tumor development by recruiting bulge stem cells, rather than through reactive oxygen species generation by polyamine catabolic oxidases.

This study found that porcine-placenta-extract-loaded nanoformulated serum improved skin hydration and promoted hair growth, as well as reduced intracellular ROS and inflammation without cytotoxicity in human subjects.

This study identified potent dual inhibitors of 5α-reductases 1 and 2 that may aid in designing new drugs for related diseases.

This review discusses the relationship between physical activity and skin aging, highlighting that regular moderate exercise may benefit skin health but excessive exercise could increase oxidative stress and damage.

This study found that lower GPX4 mRNA levels in polymorphonuclear neutrophils of systemic lupus erythematosus patients were negatively associated with disease activity and serological markers, suggesting a diagnostic value for GPX4 mRNA.

Ginseng and Albizia extracts help prevent hair thinning with age.

This study developed a rapid and efficient in vitro method using high-performance liquid chromatography to screen for steroid 5 alpha-reductase inhibitors, determining inhibition constants for Finasteride and Epristeride.

This study found that the aqueous ethanol extract of Myricae Cortex demonstrated in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic effects in mouse and hamster models.

This study established that a human epidermal model can be utilized to assess 5alpha-reductase activity and evaluate enzyme modulators, such as finasteride, for dermatological applications.

This study found that compounds from *Tectona grandis* leaves showed moderate inhibition of steroid 5α-reductase, a factor in androgenetic alopecia, and exhibited anti-inflammatory properties by inhibiting nitric oxide and pro-inflammatory cytokines IL-1β and IL-6 in vitro, suggesting potential dual-action benefits for AGA management.

This study found that Solanum nigrum L. extracts showed potential as 5 alpha-reductase inhibitors, similar to finasteride, and highlighted their promise for treating androgenic diseases like benign prostatic hyperplasia and male pattern hair loss.

In this study of male patients with 46,XY 5α-reductase type 2 deficiency, DHT therapy was effective in achieving penile enlargement during infancy, while testosterone replacement therapy proved more beneficial during puberty, possibly due to increased conversion to DHT.

This study found that the methanolic extract of Hibiscus rosa sinensis exhibits promising 5α-reductase inhibitory activity, suggesting its potential use in the treatment of androgenic conditions like male pattern hair loss and benign prostatic hyperplasia.

This study developed herbal hair oil using ingredients like castor oil, olive oil, and neem, and observed it demonstrated anti-hairfall properties as well as additional benefits such as anti-dandruff activity, improved scalp circulation, and anti-fungal properties.

In this paper, the authors detailed the role of 5-α-reductase in male androgenetic alopecia and discussed potential inhibitors like saw palmetto extracts, suggesting further investigation into their effects on hair follicles and associated biological processes.

This article discusses the potential of Bhringraj, a plant used in Ayurvedic and Unani medicine, for its significant bioactive compounds and therapeutic applications, emphasizing the importance of its extraction processes and its demonstrated non-toxic nature in rat and mice studies at high doses.

This study found that the methanolic heartwood extract of Avicennia marina significantly inhibited the enzyme 5 alpha-reductase type 1 in a cell-based assay, suggesting potential anti-androgenic effects for treating androgenic alopecia.

In this study, a self-adaptive nanozyme embedded in a madecassoside-enriched hydrogel demonstrated strong antibacterial efficacy and accelerated healing in wounds infected with drug-resistant bacteria, as evidenced by improved repair and regeneration in MRSA-infected mice and preclinical pig models.

This review discusses sexual side effects in men with androgenic alopecia treated with 5-alpha reductase inhibitors and reports no new clinical findings.

In this study, petroleum ether extracts of Phyllanthus niruri promoted hair regrowth in testosterone-induced alopecia in rats by inhibiting the 5α-reductase enzyme.

This study found that dutasteride affected spinal bone formation in curdlan-treated SKG mice, while DHT treatment reduced osteoblast differentiation in vitro, suggesting that DHT inhibition might unexpectedly increase spinal ankylosis progression in ankylosing spondylitis patients.

This study demonstrated that several botanical extracts possess antioxidant properties, reducing oxidative stress and lipid oxidation in scalp treatments, with rosemary extract showing potential to improve scalp condition in a 4-week consumer trial.

This study reports that TFM-4AS-1, a selective androgen receptor modulator, promoted bone and muscle growth with reduced effects on reproductive organs in ovariectomized rats.

This study suggests that guava leaf extract may inhibit hair loss by downregulating genes involved in androgen synthesis, potentially offering a natural alternative for treating androgenetic alopecia.

In this study, PFOS exposure altered steroid hormone levels and enzyme activities related to steroidogenesis in juvenile Silurana tropicalis, with effects differing between male and female frogs.

This study found that topical formulations including extracts from Cuscuta reflexa, Citrullus colocynthis, and Eclipta alba significantly accelerated hair growth initiation and completion in rats, indicating potential benefits for treating alopecia.

This study found that, although finasteride reduced dihydrotestosterone levels in males with heavy episodic drinking, it did not significantly alter brain activation or craving but was linked to a stronger desire not to drink.

This study found that high-dose intravenous ferric carboxymaltose may reduce inflammatory activity in patients with inflammatory bowel disease and iron deficiency anaemia, as evidenced by decreased CRP levels and improved clinical disease indices.

This study observed that intravenous ferric carboxymaltose did not inhibit the drug-induced reduction of inflammatory activity in patients with inflammatory bowel disease, as indicated by lower CRP levels.

Understanding and targeting specific molecules can help reduce scarring and promote scar-free healing.