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In this study, researchers observed that Finasteride improved cardiac function by enhancing antioxidant levels and reducing oxidative stress in obese and aging rats, though it did not benefit metabolic status and induced insulin resistance in normal diet-fed rats.

This study found that CRP levels were elevated in alopecia areata patients, with an inverse linear association between serum vitamin D and CRP levels specifically noted in ophiasis AA.

This study found that mammary resident macrophages regulate mammary epithelium cell division and development, with implications for maintaining mammary stem cell activity and homeostasis.

This research on dermal papilla cells found that Sparasis crispa increased mRNA expression related to hair production and may help in hair generation cycles, but its impact on male hair loss treatment remains uncertain.

In this study, finasteride exposure in human prostatic cell lines did not affect cell proliferation but significantly reduced MMP activity and increased TIMP expression, potentially inhibiting tumor cell invasion and metastasis.

This study identified compounds 11d and 11k as potential dual 5α-reductase inhibitors and AR antagonists with significant anti-proliferative effects on prostate cancer cell lines, suggesting they may offer therapeutic value.

This study found that 4-MA is a potent inhibitor of testosterone 5α-reductase in human tissues, promising potential for treating androgen-dependent skin conditions like male pattern baldness.

This study found that rat male costochondral chondrocytes, unlike female chondrocytes, respond to testosterone through metabolism to dihydrotestosterone, which shows a maturation-state dependent effect in male growth plate cells.

This study developed and validated a label-free assay using LC-MS to screen for S5αR inhibitors, identifying Thai herbal extracts, Impatiens balsamina L. and Curcuma longa L., as promising sources.

This study developed a reliable and convenient cell-based model to screen for type II 5α-reductase inhibitors, identifying Curcumae longae and Mori ramulus extracts as potential candidates.

This review discusses indole-based bifunctional aldose reductase inhibitors and antioxidants for diabetic complications and chronic inflammation-related pathologies, but reports no new clinical results.

This letter reports no new findings and discusses potential concerns regarding 5-alpha reductase inhibitors on lung function, suggesting a reason for discontinuation during the COVID-19 pandemic.

This study found that among 17 beta-(N-ureylene-N,N'-disubstituted)-4-azasteroids, those with an N'-phenyl moiety were the most effective inhibitors of human type I 5 alpha-reductase.

This study reports that using molecular docking methods, beta-sitosterol and stigmasterol from Serenoa repens were identified as potential natural inhibitors of the 5AR1 enzyme, which could serve as novel treatments for androgenetic alopecia based on their inhibitory action observed in a laboratory setting.

This study found that sphinganine may improve scalp health, hair quality, and reduce hair loss in males, potentially due to increased antimicrobial peptide levels and inhibition of 5-α-reductase.

This study presents the first report on cloning and characterizing the full-length cDNA of SRD5A1 in Indian catfish (Clarias magur), revealing expression differences across reproductive phases and increased expression post-Ovatide administration in ovaries and testis.

This study found that among eleven tested polymethoxyflavones, 5-hydroxy-7,4′-dimethoxyflavone was the strongest steroid 5α-reductase inhibitor and suggests potential use for benign prostatic hyperplasia treatment.

This study developed innovative silica/natural polysaccharide hybrid nanoparticles encapsulating plant-derived 5-alpha-reductase inhibitors, reporting effective controlled release at hair follicle pH and lower cytotoxicity, suggesting a promising delivery system for antiandrogenic treatments.

This review highlights that sexual dysfunction associated with 5-alpha-reductase inhibitors is recognized in clinical literature, with erectile dysfunction being the most common adverse effect, followed by ejaculatory dysfunction and decreased libido.

This study found that chitosan and surface-deacetylated chitin nanofibrils promoted hair growth in mice and increased fibroblast growth factor-7 production in human follicle dermal papilla cells.

This study identified novel compounds as selective inhibitors of the type 1 isoenzyme of 5α-reductase, displaying promising potential for treating DHT-dependent disorders such as acne and androgenic alopecia.

This study found that 10,11-dibrominecrebanine (2Br-Cre) and Stephanine demonstrate significant anti-inflammatory and analgesic properties in various experimental models, with 2Br-Cre showing enhanced efficacy over Cre and both compounds potentially mediating their analgesic effects through opioid receptors.

This study identified ten novel compounds that may effectively target steroid 5 alpha-reductase 2 (5αR-2) for potential treatment of benign prostate hyperplasia, exhibiting comparable binding energies to existing drugs like finasteride and dutasteride.

This study demonstrated that lactate dehydrogenase activity is notably high in quiescent hair follicle stem cells within mouse skin using a specific enzymatic activity assay.

This case report describes a 36-year-old Pakistani phenotypic female diagnosed with 46,XY 5-alpha-reductase deficiency, highlighting that such disorders of sexual development can manifest with symptoms like obesity, hirsutism, and amenorrhea later in life due to unique circumstances.

This study reported that the aqueous root extract of Hibiscus rosa sinesis significantly reduced inflammation in carrageenan-induced paw edema in swiss albino rats.

This study found that Lophocereus marginatus extracts significantly inhibited melanoma cell growth in vitro and stimulated hair growth in mice, with combined treatments of LM with minoxidil or bergamot showing notable effects by day 14 without altering body weight.

In this study, a new emulsion containing CBD and ginger root extract significantly reduced symptoms of dry and eczema-prone skin, such as erythema and itching, in a clinical trial.

This study demonstrated that human hair keratins have strong antioxidative properties, providing protection against oxidative stress in human dermal fibroblasts, suggesting their potential as antioxidizing supplements.

This study found that IL-6 knockout mice exhibited increased wound-induced hair neogenesis compared to wild-type mice, likely due to enhanced STAT3 activation facilitated by compensatory cytokine activity.