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This review examines the long-term health risks of anabolic-androgenic steroid abuse in athletes, reporting various physical and psychological side effects without sufficient benefits.

This study found that Epristeride and Finasteride reduced prostate development and testis weight in male rats, but only Finasteride appeared to impact reproductive function.

This study found that COVID-19 infection disrupts spermatogenesis, alters testicular cell populations, and may impact male fertility by causing long-term changes in testicular function and reduced sperm quality, as observed even in patients who have recovered from the acute phase of the infection.

This study found that finasteride treatment in adult hamsters led to significant testicular alterations and reduced spermatogenesis compared to untreated controls.

This study found that Finasteride at doses of 5 mg or higher may reduce the expression of key spermatogenesis biomarkers, potentially impacting male fertility in mice.

This study found that zinc deficiency in goats led to lower plasma zinc levels, decreased growth rate, smaller testicles, reduced libido, and was associated with higher mortality compared to control goats.

In this study, finasteride treatment for 56 days in adult rats led to sloughing of immature germinal cells and reduced sperm content in the epididymis, indicating its importance for maintaining spermatogenesis.

This study found that in male rats, finasteride significantly decreased spermatogonia and primary spermatocytes numbers and increased Leydig cells, but did not affect overall testis histology or spermatogenesis.

This study suggests that a mild intramuscular dose of botulinum toxin improved spermatogenesis and sperm parameters in ageing mice.

This study reported that semen quality improved in three young men after discontinuing long-term finasteride use, although meiotic abnormalities persisted.

This study found that untreated men with coeliac disease exhibited androgen resistance, potentially linked to sexual dysfunction, which improved as intestinal health improved, a pattern not observed in other chronic illnesses.

This study found that Origanum vulgare extract improved testicular structure and function in mice against finasteride-induced damage by enhancing antioxidant defense and modulating gene expression related to apoptosis.

This review outlines the major health consequences of anabolic-androgenic steroid abuse, with a focus on sexual and reproductive issues, and suggests management prioritizes cessation and relapse prevention due to lack of robust randomized trials.

This article reviews the effect of aging on male hormone levels and fertility, highlighting the need for more research on the benefits and risks of androgen supplementation in older men.

This review discusses the biology of spermatogenesis and male reproductive toxicology but reports no new research findings.

This study reports that two oral hormonal agents, dimethandrolone undecanoate and 11β-methylnortestosterone dodecylcarbonate, may effectively suppress hormones to contraceptive levels in men with mild side effects, though longer-term trials are required to confirm their safety and efficacy.

This review discusses hormonal changes in aging men and suggests the need for more research on androgen supplementation and partial androgen deficiency, without presenting new clinical findings.

This review reports that 5-alpha reductase inhibitors, used to treat androgenic alopecia, may adversely affect sperm count, sexual function, and hormones in a subset of patients.

This study found that activation of Wnt/β-catenin signaling in mouse testes promotes spermatogonial differentiation and reduces the stem cell pool, with SHISA6 inhibiting this process and maintaining stem cell characteristics.

This study found that administering lycopene to rats provided significant protection against the testicular damage caused by finasteride, as indicated by improved sperm parameters, and reduced oxidative stress and apoptosis markers.

This review found that both finasteride and dutasteride are effective for treating hair loss in men with androgenetic alopecia, with dutasteride showing higher efficacy, but noted unclear clinical significance regarding potential negative impacts on reproduction, including possible sexual dysfunction and effects on spermatogenesis.

This study examines the pathogenetic role of hormonal imbalances in chronic prostatitis, highlighting that decreased androgens and increased estrogens contribute to prostate inflammation and impaired spermatogenesis, and explores hormonal therapies' potential for restoring reproductive function.

This article reviews the discovery and various physiological effects of cyproterone acetate, reporting its established indications for several androgen-driven conditions but providing no new clinical data.

This study highlights the need for a comprehensive andrological assessment at diagnosis, including semen and hormonal analysis, to guide fertility preservation strategies, and found that post-orchidectomy semen samples showed improved DNA integrity for assisted reproductive technologies.

This study suggests that PrPC plays a role in the differentiation of mouse embryonic stem cells during neurogenesis, impacting neural progenitor cell development.

This study concluded that daily treatment with 1 mg finasteride did not affect spermatogenesis or semen production in young men and had small, reversible effects on prostate volume and serum PSA.

This study found that exposure to finasteride impaired spermatogenesis in male Xenopus laevis by affecting sex-specific feedback mechanisms in the hypothalamus–pituitary–gonad axis.

This review discusses the flexibility and diversity of tissue stem cell systems, particularly focusing on the motility and ligand distribution of spermatogenic stem cells, without presenting new experimental results.

This article reviews multiple entries on the Androlog blog regarding finasteride use, concluding that a 1-mg dose does not adversely affect spermatogenesis or pose a risk during conception or pregnancy.

This study found that chronic exposure to finasteride did not significantly impact spermatogenesis in rats.