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The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Silver can help prevent and treat infections but its effectiveness varies and should be weighed against costs and side effects.

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

TSH is usually the only test needed to check thyroid function in primary care.

The research found that Atypical Progeroid Syndrome has unique symptoms and is not caused by the buildup of a certain mutant protein.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

Choosing the right model order in brain connectivity analysis can affect the detection of differences between healthy individuals and those with seasonal affective disorder.

Microneedling is promising for treating various skin issues but needs more research to confirm its effectiveness and safety.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Thymus transplantation successfully restored immune function in infants with FOXN1 deficiency.

Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.

Hidradenitis suppurativa is caused by genetic factors, inflammation, bacteria, hormones, and lifestyle factors like obesity and smoking.

The document says to treat cat fungal infections with medicine and clean the environment, noting that cats without symptoms can still spread it to humans.

Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.

Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.

Cats with atopic dermatitis often have severe, year-round itching and respond well to certain treatments.

Products should be called 'sperm-safe' only after thorough, well-designed tests.