232 citations,
October 2015 in “International journal of molecular sciences” Stem cells are crucial for skin repair and new treatments for chronic wounds.
151 citations,
February 2007 in “International Journal of Dermatology” Alopecia areata causes hair loss, has no cure, and various treatments exist.
138 citations,
June 2019 in “Stem Cells and Development” Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.
124 citations,
June 2020 in “Cell Stem Cell” Fat cells in the skin help start healing and form important repair cells after injury.
120 citations,
February 2009 in “Apoptosis” Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.
89 citations,
November 2017 in “Journal of Cellular Physiology” The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.
88 citations,
May 2012 in “Human Reproduction Update” Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.
83 citations,
July 2008 in “Current Opinion in Chemical Biology” The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.
70 citations,
February 2015 in “Expert Opinion on Drug Discovery” Topical drugs and near-infrared light therapy show potential for treating alopecia.
67 citations,
December 2019 in “PloS one” Beta-caryophyllene helps improve wound healing in mice, especially in females.
60 citations,
September 2015 in “Expert Review of Clinical Immunology” Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.
59 citations,
September 2008 in “Experimental dermatology” Both mouse and rat models are effective for testing alopecia areata treatments.
51 citations,
October 2002 in “British Journal of Dermatology” Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.
47 citations,
November 2012 in “Wound repair and regeneration” Nude mice with grafted human skin developed scars similar to human hypertrophic scars.
45 citations,
July 2009 in “Journal of Investigative Dermatology” The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.
45 citations,
September 1998 in “Journal of Investigative Dermatology” The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.
39 citations,
April 2020 in “IntechOpen eBooks” Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.
35 citations,
May 2012 in “Expert Opinion on Pharmacotherapy” The document concludes that there are various treatments for different types of alopecia, but more research is needed for evidence-based treatments.
33 citations,
September 2012 in “Wound Repair and Regeneration” Applying calreticulin can speed up wound healing in diabetics.
31 citations,
June 2017 in “Regeneration” BMP2 needs periosteal tissue to help regenerate mouse middle finger bones within a specific time.
30 citations,
June 2014 in “Seminars in Immunology” Future research on ectodysplasin should explore its role in diseases, stem cells, and evolution, and continue developing treatments for genetic disorders like hypohidrotic ectodermal dysplasia.
28 citations,
February 2019 in “Genes” Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.
28 citations,
September 2015 in “Wiener Klinische Wochenschrift” New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.
28 citations,
August 2015 in “Journal of functional biomaterials” Cell-based therapies show promise for treating Limbal Stem Cell Deficiency but need more research.
28 citations,
January 2011 in “Hearing Research” Gene therapy, especially using atoh1, shows promise for creating functional sensory hair cells in the inner ear, but dosing and side effects need to be managed for clinical application.
26 citations,
May 2021 in “International Journal of Molecular Sciences” Cheonggukjang may help prevent and manage various diseases and improve overall health, but its odor and safety concerns need addressing.
23 citations,
January 2014 in “International Journal of Biological Sciences” African American men with prostate cancer have more androgen receptor mutations, which may lead to more aggressive cancer compared to Caucasian American men.
21 citations,
November 2017 in “Archives of Dermatological Research” Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.
21 citations,
August 2003 in “Seminars in oncology nursing” Nurses are crucial in managing chemotherapy side effects for ovarian cancer patients to improve their quality of life.
19 citations,
January 2011 in “Obstetrics and gynecology international” Red clover extract improved hair, skin, mood, sleep, and tiredness in postmenopausal women.