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This study found that the Notch signaling pathway is suppressed in basal cell carcinomas and highly expressed in hair follicles, suggesting it might be a target for treatment strategies.

This review discusses genetically-engineered mouse models for studying melanocytes and reports no new experimental findings; it emphasizes their potential to address unanswered questions in melanoma biology.

This review highlights recent advancements in androgenetic alopecia treatment, focusing on the dysregulated signaling pathways involved in hair follicle regeneration and exploring innovative therapeutic strategies, including small molecule modulators and gene editing technologies, which show promise in preclinical models.

This review explored the causes of hair graying and evaluated how plant-derived extracts and phytochemicals might alleviate it, noting that certain compounds showed potential in enhancing melanocyte function, reducing oxidative stress, and influencing stress-related pathways based on experimental evidence.

This study found that extracts from heterotropic cultures of Scenedesmus deserticola JD052 enhanced hair-inductive properties in human dermal papilla cells more effectively than photoautotrophic extracts, likely through activation of AKT/β-catenin signaling, despite similar loliolide content.

This study found that deleting the Hes1 gene disrupts hair regeneration by delaying anagen initiation and shortening the anagen phase, suggesting it's crucial for maintaining hair cycle homeostasis.

This genome-wide association study identified several genetic markers, including specific SNPs and HLA genotypes, associated with alopecia areata susceptibility in the Taiwanese population, highlighting key pathways involved in immune response and offering insights into the genetic origins of this autoimmune condition.

This study found that the creation of hair follicle lumens in mice is driven by the outward migration of keratin 79-positive cells, suggesting a novel mechanism for generating hollow cores in hair follicles.

In this study, researchers identified a new dominant mutation in Hairless mice, called Pied, resulting from a deletion in the Adam10 gene, which causes freckle-like skin pigmentation by inhibiting melanocyte expansion.

This study found that the absence of Hif-p4h-2 in specific mouse skin cells disrupted hair follicle development, leading to hair loss due to irregular keratin formation and pathway signaling.

In this mouse model study, researchers found that deleting the ASH2L gene in epidermal progenitor cells led to thinner epidermal layers, delayed hair follicle development, and reduced epidermal stem cell pools, with alterations in genes related to hair follicle development and the Notch signaling pathway.

In this study, knockout of B-raf and C-raf genes in mice showed they are not needed for early melanocyte development, but are crucial for maintaining melanocyte stem cells, as evidenced by hair graying due to stem cell depletion.

This narrative review examines the interactions between skin stem cells and their niches, finding new insights from advancements in genetic and imaging tools but reporting no new experimental results.

This review discusses the molecular mechanisms involved in hair follicle development and regeneration, highlighting findings from mouse genetic studies, and reports no new experimental results.

This review evaluates methods to study stem cell division patterns, particularly in the mammary gland, and discusses genetic factors affecting division modalities and their implications for breast cancer, but reports no new results.

This review summarizes how single-cell omics technologies have advanced understanding of cellular regulatory programs in sheep and goats, but highlights limitations in genomic annotation and integration with population genetics for molecular breeding.

This study observed that after hair cell loss in the mouse cochlea, supporting cells were replaced by migrating non-specialised cells, with genetic background affecting the rate of tissue re-organization.

This study suggests that phenotypic plasticity, including processes like dedifferentiation and transdifferentiation, plays a crucial role in cancer initiation, progression, and therapy resistance, broadening our understanding of cancer dynamics and potential treatment strategies.

This study found that combining platelet-rich plasma with adipose-derived mesenchymal stem cells significantly improved diabetic wound healing in rats by enhancing angiogenesis and modulating the Notch signaling pathway.

This study reported the expression patterns and potential functions of long non-coding RNAs in the hair follicle cycle of yak, with insights into their sequence conservation between yak and cashmere goat.

This research discusses how epithelial stem cells in the skin maintain normal homeostasis, contribute to wound repair, and highlights the importance of these processes, as defects can lead to skin diseases including cancers, but provides no new experimental results.

This study found that Argan press cake extracts stimulated hair growth and reduced inflammation and oxidative stress in human hair follicle dermal papilla cells, suggesting potential for anti-hair loss drug development.

In this study, researchers identified PSENEN mutations that can lead to a form of Dowling-Degos disease, characterized by follicular hyperkeratosis and an increased susceptibility to acne inversa, especially in the presence of certain trigger factors.

In this study, researchers found that Notch signaling is crucial for late-stage epidermal differentiation and postnatal hair cycle homeostasis by regulating hair follicle stem cell proliferation and differentiation.

This article offers a viewpoint on hidradenitis suppurativa pathogenesis, suggesting that impaired Notch signalling from γ-secretase mutations may drive inflammation and link the condition to other Th17-driven diseases.

This study found that Notch signalling promotes differentiation of epidermal cells and acts as a tumour suppressor in the skin by interacting with various pathways and mechanisms.

This study found that stress-induced inactivation of the enzyme Dicer in melanocytes can cause premature hair greying by preventing proper melanocyte placement and melanin transfer in mice, suggesting the Dicer-miR92b-ItgaV pathway as an important link between stress and grey hair.

This study found that treatment with the polyphenolic compound TCQA activated β-catenin, promoting hair regrowth and the initiation of the anagen phase in mice and human dermal papilla cells.

This review discusses the role of Notch signaling in skin diseases such as Hidradenitis Suppurativa and Psoriasis, but reports no new clinical results.

This narrative review explores the molecular mechanisms driving skin development and their role in skin diseases, emphasizing how disruptions in these pathways can lead to conditions like congenital disorders and cancers, potentially guiding new targeted therapies.