This correspondence suggests that while patients with Raynaud phenomenon may develop connective tissue disorders, physicians should consider this possibility without assuming for certain that progression will occur.
This letter challenges Dr. Dubois' statement that nearly all patients with Raynaud phenomenon will develop a systemic disorder, arguing that many experience it without progressing to serious disease.
3 citations
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March 2025 in “Arthritis Research & Therapy” This study found that combining high-density fat grafting with botulinum toxin A significantly improved symptoms of Raynaud’s phenomenon, including reducing pain and cold sensitivity, speeding up ulcer healing, and enhancing blood perfusion, compared to fat grafting alone.
58 citations
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February 2021 in “Toxins” This review concluded that botulinum toxins have various potential off-label uses for dermatological conditions, but further research is needed to fully establish their efficacy and safety in these applications.
48 citations
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October 2011 in “Sports Medicine” This review covers dermatological conditions experienced by ice-skating athletes due to cold exposure, infections, and inflammation, providing no new clinical findings and emphasizing diagnosis and treatment strategies.
15 citations
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July 1991 in “International Journal of Dermatology” This article discusses the technique of laser Doppler velocimetry for measuring cutaneous blood flow and does not report new research findings.
1 citations
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January 2018 in “ARC Journal of Dermatology” A patient had both chronic lupus and systemic scleroderma, requiring careful treatment to manage symptoms.
This study found significant correlations between scalp and nail involvement and laboratory findings in Korean patients with chronic cutaneous lupus erythematosus, highlighting their importance for diagnosis and management.
December 2022 in “Biological and Clinical Sciences Research Journal” This study found that among mixed connective tissue disease patients in a tertiary care hospital in Pakistan, Raynaud phenomenon was the most common clinical feature, present in 80% of patients.
February 2010 in “Journal of The American Academy of Dermatology” A woman's nail separation was likely caused by poor blood flow, and a treatment for similar conditions might help.
January 2005 in “Chinese Journal of Integrated Traditional and Western Nephrology” This study found that systemic lupus erythematosus in aging patients often presents with atypical clinical manifestations, leading to more frequent misdiagnosis, yet these patients may respond better to treatment.
November 2023 in “International Journal of Trichology” This case report describes a 19-year-old male with systemic lupus erythematosus presenting with an unusual combination of mucinous nonscarring alopecia and papulonodular mucinosis, noted by mucin deposition in skin lesions, which responded partially to treatment with hydroxychloroquine and prednisolone.
132 citations
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July 2000 in “Lupus” This study found that chronic cutaneous lupus erythematosus with discoid lesions was the most common skin manifestation among patients with lupus erythematosus, while nonspecific skin lesions were linked to systemic lupus erythematosus, particularly during active disease phases.
127 citations
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September 1996 in “British Journal of Dermatology” This study found that cutaneous signs such as chilblains and urticaria were notably common in British patients with systemic lupus erythematosus, while subacute cutaneous lesions were less frequent.
107 citations
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November 2008 in “The Journal of Rheumatology” This study found that fibromyalgia prevalence is slightly higher in patients with systemic lupus erythematosus compared to those with arthritis, but fibromyalgia-ness does not bias the SLE Activity Questionnaire.
62 citations
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June 2011 in “Lupus” This study found that male patients with systemic lupus erythematosus had a higher prevalence of certain complications like thromboses and nephropathy than female patients, suggesting gender influences the disease's clinical expression.
53 citations
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January 2017 in “Skin appendage disorders” This review discusses botulinum toxin's experimental off-label uses in dermatology, highlighting promising results but emphasizing the need for more clinical trials to confirm efficacy and safety.
11 citations
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September 2021 in “Anais Brasileiros de Dermatologia” This article reviews how skin manifestations can aid in diagnosing various systemic diseases, focusing primarily on their association with rheumatologic conditions while also addressing vascular, granulomatous, and other disease impacts, aiming to provide dermatologists with practical diagnostic insights.
10 citations
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October 1992 in “PubMed” This case study suggests that thrombosis was related to anti-phospholipid antibody in a woman with systemic lupus erythematosus, characterized by multiple aseptic bone necroses and arterial blockages.
5 citations
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January 2016 in “European Journal of Dermatology” Suplatast tosilate successfully treated a woman's systemic sclerosis symptoms.
2 citations
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December 2023 in “Mediterranean Journal of Rheumatology” This study reports that late onset systemic lupus erythematosus in India shows distinct clinical and serological characteristics compared to young onset cases, particularly in symptoms such as interstitial lung disease and autoantibody profiles.
research Skin
2 citations
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January 2011 in “Elsevier eBooks” This review discusses approaches to diagnosing and managing cutaneous manifestations of lupus erythematosus and reports no new clinical results.
2 citations
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January 2004 in “Elsevier eBooks” This article reviews historical uses of the term "lupus" for various skin disorders but provides no new clinical findings.
February 2025 in “Indian Dermatology Online Journal” This case report describes a rare occurrence of pincer nail deformity in a patient with systemic lupus erythematosus, potentially linked to Raynaud's phenomena as a contributing factor.
August 2023 in “The American Journal of Medicine” This case report describes a 17-year-old female patient diagnosed with systemic lupus erythematosus, presenting with arthralgia, hair loss, and Raynaud's phenomenon. The diagnosis was supported by elevated ESR and positive autoantibodies, and treatment included hydroxychloroquine and prednisone.
January 2019 in “Medicine Science | International Medical Journal” This study found that specific skin lesions are common indicators of pediatric rheumatologic diseases, potentially aiding dermatologists and rheumatologists in diagnosis when biopsies are challenging.
April 2018 in “International Journal of Research in Dermatology” In this study, 82% of systemic lupus erythematosus patients at a tertiary care center in India exhibited skin manifestations, including photosensitivity, malar rash, discoid rash, and oral ulcers.
June 2016 in “Annals of the Rheumatic Diseases” This study identified early SLE symptoms reported by German patients, suggesting that patient-reported information can enhance the development of classification criteria for early diagnosis.
January 2014 in “International Journal of Case Reports and Images” This case report describes a 62-year-old woman diagnosed with undifferentiated connective tissue disease and renal amyloidosis, presenting symptoms like joint pain, Raynaud's phenomenon, and carpal tunnel syndrome.
November 2012 in “The Journal for Nurse Practitioners” This article discusses the complexities of diagnosing systemic lupus erythematosus and its potential triggers but reports no new clinical findings.