Finding functions for unknown GPCRs is hard but key for making new drugs.
1 citations,
November 2008 Yonnyuniksoogobon-dan taken orally promotes hair growth by affecting growth factors in hair roots.
April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.
February 2024 in “Frontiers in physiology” Hair follicle stem cells help skin heal and grow during stretching.
Recombinant human growth hormone helps burn wounds heal faster by increasing blood vessel growth.
December 2023 in “Frontiers in pharmacology” Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.
December 2023 in “International Journal of Advanced Research in Science, Communication and Technology” Semecarpus anacardium Linn. is a plant with many health benefits, including reducing inflammation, fighting cancer, and stimulating hair growth.
December 2023 in “Journal of the Endocrine Society” Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.
November 2023 in “Deleted Journal” Cedrus libani has potential medicinal uses but needs more safety studies.
June 2023 in “Journal of Ayurvedic and herbal medicine” Pumpkin seeds may improve health due to their rich nutrients and potential to treat various conditions.
Female rats showed more panic-related behavior than males, influenced by hormonal cycles and certain drugs.
November 2022 in “CARDIOMETRY” A group has developed therapies that show promise for treating cancer and various other conditions.
August 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” Mouse touch-sensitive nerve cells adjust their connections based on competition with other similar cells.
September 2021 in “International Ayurvedic Medical Journal” Bhringraj capsule and oil with Nasya effectively reduce hair fall and related symptoms.
June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” KIF18B is important for correctly positioning cell division machinery in skin cells, affecting hair follicle development.
May 2021 in “Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas” Microsechium helleri extract has antioxidant, anti-inflammatory, antidiabetic, and heart-protective benefits.
December 2020 in “Nigerian journal of animal production” Dexamethasone can cause diabetes in rats, and Annona muricata bark extract may help lower blood sugar.
December 2020 in “Current Sexual Health Reports” Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.
July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.
L-PGDS has specific binding sites for its functions and could help in drug delivery system design.
November 2018 in “Atlas of genetics and cytogenetics in oncology and haematology” WNT10B is linked to cancer development and affects survival and disease progression in various cancers.
Cornification is the process where living skin cells die to create a protective barrier, and problems with it can cause skin diseases.
October 2017 in “Springer eBooks” A thorough initial check-up is essential before sperm banking to ensure the best chance of preserving good quality sperm.
July 2017 in “International journal of Ayurvedic and herbal medicine” Madayantika Siddha Taila is effective for treating Seborrhea capitis.
January 2000 in “BioScience” The document concludes that understanding hair biology is key to treating hair disorders, with gene therapy showing potential as a future treatment.
13 citations,
April 2018 in “Scientific Reports” The genes KRT25 and SP6 affect curly hair in horses, with KRT25 also causing hair loss. If both genes are mutated, the horse gets curly hair and hair loss. KRT25 can hide the effect of SP6.
5 citations,
April 2014 in “Journal of Lipid Research” SCD1 inhibitors can cause skin issues in rodents.
2 citations,
April 2021 in “FEBS open bio” Human hair keratins K85 and K35 create unique filament patterns important for early hair formation.
1 citations,
January 2021 in “European Journal of Inflammation” Methylated flavonoids may effectively reduce depression and inflammation caused by finasteride.
166 citations,
February 2005 in “Behavioural brain research” Vitamin D receptor knockout mice have significant motor impairments but no cognitive deficits.