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DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

Vitamin D3 affects cell differentiation in specific skin areas.

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

Finasteride causes lasting fertility decrease in rats.

Researchers found a gene in hamsters that responds to male hormones and may be indirectly controlled by them.

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

Oxidative stress affects hair loss in men with androgenetic alopecia.

Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

The document concludes with guidance for doctors on diagnosing and treating hirsutism effectively and safely.

The combination of cyproterone acetate and testosterone enanthate is highly effective in preventing sperm production and could be a good reversible male contraceptive.

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

Spironolactone did not make hair thinner in women with excess hair growth.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Male hormones indirectly affect skin cell development by increasing growth factor levels from skin fibroblasts.

Aldactone was more effective in reducing hair growth in women with hirsutism than Diane, despite having less impact on hormone levels.

A drug called cimetidine can help treat hair loss in women by blocking androgen receptors. However, it's not the first choice and needs more research.

Minoxidil effectively promotes hair regrowth in younger patients with small balding areas.

Cyproterone acetate with ethinyl estradiol is effective for treating skin symptoms related to high androgen levels, like in PCOS.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Topical minoxidil is the most promising treatment for male pattern hair loss, but more research is needed to confirm its effectiveness and safety.

Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.

Androgen therapy can help with symptoms like low libido in women, but more research is needed to understand its long-term safety and effects on health.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Testosterone affects hair follicles differently across body sites, with beard hair follicles showing more activity of a specific enzyme and presence of androgen receptors compared to scalp hair.

Hibiscus rosa sinensis may help manage hair loss.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.