December 2025 in “International Journal of Molecular Sciences” This review examined 40 studies on exosome-based therapies for alopecia areata, reporting significant hair regrowth and improvements in hair count, length, and thickness, but highlighted the need for standardized methodologies and robust RCTs before clinical application.
66 citations
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June 2015 in “Aesthetic Plastic Surgery” This review of 47 studies indicates that platelet preparations may significantly enhance cellular activity, wound healing, and facial aesthetic outcomes in facial plastic surgery, though potential publication bias should be considered.
3 citations
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November 2021 in “Clinical, Cosmetic and Investigational Dermatology” This review evaluated existing studies on platelet-rich plasma for facial rejuvenation and found limited clinical evidence supporting its effectiveness, suggesting that more research is needed to establish its utility.
October 2025 in “Journal of Cosmetic Dermatology” In this study, researchers found that type A botulinum toxin injections can reduce hypertrophic scars effectively, though more high-quality studies are needed to confirm the precision and stability of these therapeutic effects.
This systematic review examined the potential of microneedling for anterior neck scars but found no eligible studies directly investigating this application. Indirect evidence from other body regions suggests possible benefits, underscoring the need for targeted research to validate these findings for neck surgery patients.
This research review found that spironolactone can significantly improve acne severity more effectively than a placebo, with 73.3% of patients reporting satisfaction despite a 26.7% rate of adverse events among the 1,548 participants studied.
December 2024 in “Revista Brasileira de Plantas Medicinais” This study reviewed in vivo studies and clinical trials on phenolic compounds, like tannins and flavonoids, for treating hair loss, noting their antioxidant and anti-inflammatory effects but highlighting the need for more clinical trials to confirm benefits.
164 citations
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April 2008 in “Cochrane library” This review of interventions for alopecia areata found no significant treatment benefits for hair growth compared to placebo, indicating a need for larger, well-conducted studies.
This review presents evidence supporting acupuncture's potential benefits for AA treatment but notes the findings are limited by low-quality evidence and small sample sizes, suggesting a need for future large-scale, rigorous studies.
9 citations
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February 2021 in “Evidence-based Complementary and Alternative Medicine” This study reported that Longdan Xiegan decoction is more effective than conventional western medicine alone in treating eczema, but the evidence quality was generally low, highlighting the need for further studies.
September 2023 in “Medical & Clinical Case Reports Journal” This review found that while platelet-rich plasma treatment significantly increased hair density compared to baseline in people with androgenetic alopecia, its effectiveness was not significant compared to placebo in most studies.
52 citations
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January 2001 in “Eye” This review discusses challenges in treating CMO associated with uveitis and highlights the need for prospective studies to guide therapy, as current treatments are largely empirical and potentially harmful.
7 citations
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November 2003 in “Current Opinion in Obstetrics & Gynecology” This review summarizes recent studies on metformin for polycystic ovary syndrome, reporting its beneficial effects on endocrine, metabolic, and reproductive outcomes, but highlights ongoing debate about its mechanisms.
40 citations
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August 2018 in “Journal of the American Academy of Dermatology” This study reported that a 10-week course of clindamycin and rifampicin was commonly used for treating folliculitis decalvans but the evidence on its efficacy remains inconclusive due to the low quality of available studies.
9 citations
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April 2024 in “Heliyon” This review highlighted significant properties of probiotics that can promote hair growth and reduce dandruff, offering guidance for future research to scale these findings to pilot studies.
9 citations
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August 2014 in “Journal of The American Academy of Dermatology” This article discusses the authors' concerns over the misinterpretation of studies linking smoking and frontal fibrosing alopecia, clarifying that neither study suggests smoking is protective against the condition.
7 citations
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April 2008 in “Annals of pharmacotherapy/The annals of pharmacotherapy” This review discusses the use of acarbose for managing polycystic ovary syndrome and notes positive but limited evidence from small trials, indicating a need for more rigorous studies.
2 citations
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April 2017 in “Health technology assessment in action” This study reviewed previous research and found that while mesotherapy appears to improve outcomes in treating androgenetic alopecia without significant adverse effects, the supporting studies were of poor quality, and further research is necessary to confirm its efficacy and safety.
19 citations
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October 2018 in “Medicine” In this meta-analysis, researchers found that moxibustion combined with oriental herbal medicine may improve pregnancy rates and other outcomes in women with polycystic ovary syndrome compared to western medication alone; however, the evidence is limited by the poor quality of included studies.
3 citations
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August 2015 in “Clinical and Experimental Obstetrics & Gynecology” This review discusses treatment options for hair loss in women and reports no new clinical results; it highlights minoxidil as the only drug proven to effectively improve alopecia based on rigorous studies.
4 citations
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December 2014 in “PubMed” This review suggests that dihydrotestosterone pretreatment may improve cosmetic outcomes in hypospadias repair, but more randomized trials are needed to determine its effectiveness due to currently limited evidence.
July 2022 in “British Journal of Dermatology” This systematic review observed that Janus kinase inhibitors show promising efficacy for treating alopecia areata, but more studies on adolescent treatments and patient-relevant outcomes are needed.
June 2026 in “JAAD reviews.” This review suggests that low-dose oral minoxidil may enhance hair density in certain nonandrogenetic alopecias, but highlights the need for controlled trials due to mixed and limited evidence.
August 2024 in “Clinical Cosmetic and Investigational Dermatology” This study investigates the potential causal relationship between hypothyroidism and hair loss conditions like alopecia areata and androgenetic alopecia, noting that previous studies have reported inconsistent findings. Results are not yet detailed.
11 citations
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August 2020 in “Dermatologic therapy” This review article highlights that mesotherapy, a popular non-surgical procedure in aesthetic dermatology, involves injecting a mixture of compounds into the skin for purposes like skin rejuvenation and hair loss treatment, but lacks large-scale studies on its efficacy and safety.
7 citations
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May 2016 in “SpringerPlus” This review suggests that treating endocrine therapy-induced hair loss in breast cancer patients with topical 5-alpha reductase inhibitors and supplements like Vitamin C and omega-3 fatty acids may be effective, but further studies are needed.
24 citations
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January 2017 in “Journal of Cutaneous and Aesthetic Surgery” In this pilot study, botulinum toxin was found to be a safe and effective treatment for androgenetic alopecia in most participants, though larger studies are needed to confirm these findings.
113 citations
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July 2020 in “International Journal of Molecular Sciences” This review suggests that allogenic adipose stem cell and extracellular matrix transplants may be safe and effective for various medical conditions, based on available studies.
40 citations
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August 2018 in “Skin appendage disorders” This review examines complementary and alternative medicine for alopecia and finds limited support from robust clinical trials, highlighting the need for standardized studies to evaluate efficacy and safety.
14 citations
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September 2019 in “Eye” This review discusses the evidence for using oral medications to treat central serous chorioretinopathy, highlighting eplerenone as having the most support despite a lack of robust efficacy across studies.