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The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Mice hair growth patterns get more complex with age and can change with events like pregnancy or injury.

Stress can stop hair growth in mice, and treatments can reverse this effect.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

MIM is crucial for hair follicle formation and regeneration by controlling cilia formation and hedgehog signaling through its interaction with Cortactin and Src.

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

Ruby laser pulses best destroy hair follicles during the growth phase and effectiveness varies with laser intensity; melanin is key for targeting, and timing treatments can improve results.

Understanding the mouse hair cycle is crucial for cancer research.

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.

Hair loss in men treated best with early medication or transplant, new treatments researched.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

EGF makes hair follicles grow longer but stops hair production.

Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.

Mouflon rams mature gradually with changes in body, horns, and hormones linked to age and seasons, reaching full sexual maturity well after puberty.

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

Mice without the Sept4/ARTS gene heal wounds better due to more stem cells that don't die easily.