April 2022 in “Research Square (Research Square)” The combination of laser and topical steroids is more effective for treating alopecia areata than topical steroids alone.
520 citations,
February 2001 in “Journal of Clinical Investigation” VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
384 citations,
June 2005 in “Genes & development” β-catenin is essential for stem cell activation and proliferation in hair follicles.
378 citations,
November 2011 in “Human reproduction update” Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.
343 citations,
December 2008 in “Endocrine Reviews” Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.
264 citations,
January 2008 in “Journal of biomedical optics” Zinc oxide nanoparticles in sunscreen do not penetrate deep into the skin.
237 citations,
February 2016 in “Science Translational Medicine” The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.
202 citations,
August 2007 in “Biomaterials” Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.
200 citations,
November 1997 in “Planta” Calcium affects where root hairs grow, but other unknown factors determine their growth direction.
163 citations,
March 2012 in “BMC biology” Stem cell niches support, regulate, and coordinate stem cell functions.
Dermatoscopy and videodermatoscopy are useful for diagnosing and monitoring various skin, hair, and nail conditions.
96 citations,
October 2000 in “The FASEB Journal” The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.
94 citations,
January 2016 in “Journal of the European Academy of Dermatology and Venereology” Sensitive skin is often caused by nerve fibers and environmental factors, and can be managed with mild skincare and professional advice.
80 citations,
June 2008 in “Biomaterials” EVAL membranes help create cell structures that can regrow hair follicles.
65 citations,
March 2016 in “Lasers in Medical Science” Most low-level light therapy studies did not accurately report how light was measured, affecting treatment reliability.
65 citations,
January 2013 in “Cochrane library” Some systemic treatments work for nail psoriasis but can have serious side effects.
62 citations,
April 2008 in “Neurobiology of aging” Scientists found a gene in mice that causes early hearing loss.
45 citations,
February 2019 in “Journal of Affective Disorders” Melatonin improved mental health and metabolism in women with PCOS.
44 citations,
August 2010 in “Lupus” Lupus can affect the scalp and nails, often causing hair loss and nail damage, and needs early aggressive treatment to prevent permanent damage.
42 citations,
September 2017 in “Advances in protein chemistry and structural biology” Surface Plasmon Resonance is a useful tool for studying protein interactions and has potential for future technological advancements.
37 citations,
June 2011 in “Journal of Cellular Biochemistry” Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.
36 citations,
July 2016 in “Scientific reports” People's decision-making can be influenced by their internal biological clocks, as shown by gene expression, not just self-reported preferences for morning or evening.
35 citations,
May 2012 in “Cochrane Database of Systematic Reviews” Minoxidil effectively treats female pattern hair loss.
34 citations,
January 1977 in “American Journal of Cardiology” 29 citations,
November 2014 in “Experimental Dermatology” Injecting alpha-melanocyte-stimulating hormone in mice improved skin healing and reduced scarring.
29 citations,
July 2009 in “Journal of Dermatology” 5% minoxidil works better for hair growth than 1% minoxidil.
27 citations,
May 2007 in “Archives of dermatological research” Diphencyprone treatment increases CD8 lymphocytes in the scalp, which is associated with hair regrowth in alopecia areata patients.
26 citations,
October 2011 in “International Journal of Biological Macromolecules” Some newly made compounds are promising for treating enlarged prostate, hair loss, viruses, and prostate cancer, and might be better than current drugs.
25 citations,
July 2013 in “Environmental Toxicology and Chemistry” Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.
24 citations,
May 2019 in “PLOS ONE” The African spiny mouse can fully regenerate its muscle without scarring, unlike the common house mouse.