421 citations
,
January 2015 in “Chemical Society Reviews” This review discusses recent advances in surface modification and endothelialization of biomaterials for vascular grafts, highlighting promising methods like gene engineering and targeting ligand immobilization to improve clinical outcomes.
343 citations
,
March 2016 in “Nature Communications” This study found that IL-17A-producing γδ T cells play a key role in bone fracture healing by promoting bone formation, with deficiencies leading to impaired repair in mice.
212 citations
,
September 2015 in “Journal of Investigative Dermatology” This article presents a comprehensive guide for classifying human hair follicle cycle stages in vivo using scalp xenografts on immunocompromised mice, offering valuable resources for researchers in the field.
192 citations
,
April 2019 in “ACS nano” In a mouse model, this study demonstrated that a microneedle patch system using keratin and integrated with MSC-derived exosomes and UK5099 promoted hair regrowth more efficiently than traditional delivery methods.
136 citations
,
February 2017 in “International Journal of Molecular Sciences” This study observed that autologous platelet-rich plasma treatment improved hair count and density in areas with androgenetic alopecia compared to placebo, with differing outcomes based on the PRP collection device used.
132 citations
,
January 2017 in “International Journal of Molecular Sciences” This review explores how adipose-derived stem cells contribute to skin homeostasis and highlights recent advances in their clinical applications in dermatology, but it reports no new clinical results.
92 citations
,
September 2019 in “ACS nano” This study observed that a wearable electric stimulation device significantly promoted hair regeneration in rats and mice, outperforming conventional pharmacological treatments and enhancing growth factor secretion.
87 citations
,
March 2020 in “Australian Dental Journal” This review discusses different preparation and application methods of platelet-rich plasma in dental regenerative medicine and reports no new results, highlighting its potential and associated controversies.
70 citations
,
February 2017 in “Dermatologic Surgery” This study reports that plasma rich in growth factors appeared to improve hair follicle regeneration and patient satisfaction in individuals with androgenetic alopecia, though further trials are needed.
69 citations
,
April 2019 in “Biomedicines” This study found that hair thickness and density increased after treatment with human follicle mesenchymal stem cells and platelet rich plasma, associated with enhanced Wnt signaling and platelet derived growth factors.
65 citations
,
July 2020 in “Science Advances” Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.
64 citations
,
March 2017 in “Journal of Cosmetic Dermatology” This meta-analysis suggests that local injection of platelet-rich plasma for androgenic alopecia is associated with an increased number of hairs and some increase in hair thickness, though larger studies are needed for confirmation.
57 citations
,
May 2016 in “Journal of Dermatological Treatment” This analysis suggests that platelet-rich plasma therapy may be promising for treating androgenetic alopecia, but further controlled trials with standardized measures are needed to confirm its efficacy.
54 citations
,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This speculative review discusses hair cycle-dependent fibroblast dynamics and possible impacts on human hair growth, synthesizing current literature without presenting new clinical findings.
53 citations
,
June 2017 in “Skin appendage disorders” This review suggests that platelet-rich plasma may be effective in increasing hair density in patients with androgenetic alopecia, but more research is needed to determine the best treatment protocol.
46 citations
,
September 2013 in “PLOS ONE” This study identified thyrotropin-releasing hormone (TRH) as a stimulant of wound healing in both frog and human skin models, suggesting it as a potential neuroendocrine wound repair promoter.
39 citations
,
July 2021 in “Stem Cell Research & Therapy” This study found that combining platelet-rich plasma with adipose-derived mesenchymal stem cells significantly improved diabetic wound healing in rats by enhancing angiogenesis and modulating the Notch signaling pathway.
36 citations
,
April 2018 in “Journal of Investigative Dermatology” This study found that transforming growth factor-β1 and CX3CR1 are crucial for recruiting specific macrophages essential for wound-induced hair growth in mice.
31 citations
,
January 2019 in “Journal of Cutaneous Medicine and Surgery” This review found that three monthly PRP injections improved hair density in patients with androgenetic alopecia compared to placebo, but more rigorous studies are needed for broader dermatological applications.
31 citations
,
April 2018 in “Plastic and Reconstructive Surgery” This review discusses the use of platelet-rich plasma for facial rejuvenation, acne scarring, and androgenic alopecia and reports positive outcomes but emphasizes the need for standardized preparation and application methods.
31 citations
,
January 2017 in “Advances in Experimental Medicine and Biology” This review discusses the negative health impacts of testosterone deficiency and the potential adverse effects of 5α-reductase inhibitors, emphasizing the need for patient-physician discussions regarding these treatments.
29 citations
,
September 2020 in “International Journal of Molecular Sciences” This review outlines the current state of freeze-dried platelet-rich plasma (FD-PRP) research, emphasizing its use in wound healing, lumbar fusion, knee conditions, and dentistry, but reports no new clinical findings.
29 citations
,
January 2018 in “International Journal of Trichology” This meta-analysis reported that platelet-rich plasma injections for androgenetic alopecia may increase hair number and thickness locally, but further studies are needed to establish their overall effectiveness.
28 citations
,
August 2000 in “Current Opinion in Chemical Biology” This article reviews current osteoporosis treatments, focusing on the potential of selective androgen receptor modulators and other agents to enhance bone formation, but provides no new clinical data.
27 citations
,
July 2017 in “Facial Plastic Surgery” This review examines the growing evidence for using platelet-rich plasma in aesthetic procedures such as hair restoration and skin rejuvenation but reports no new clinical results.
27 citations
,
May 2016 in “Dermatologic Surgery” This review examines how male facial anatomy and behavior contribute to sexual dimorphism in facial aging, pointing to factors that accelerate aging in men but presents no new clinical results.
26 citations
,
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, loss of epidermal Par3 in mice disrupted the skin barrier and affected cell differentiation and stem cell maintenance, highlighting its role in epidermal homeostasis.
25 citations
,
September 2018 in “Scientific Reports” This study found that morroniside enhanced hair follicle growth and transition through the Wnt/β-catenin signaling pathway in a mouse model, suggesting its potential as a treatment for hair loss.
24 citations
,
January 2021 in “Dermatologic Therapy” This review found that platelet-rich plasma therapy improved hair growth and thickness in most studies on alopecia, with the highest improvement seen when combined with Minoxidil.
23 citations
,
June 2018 in “Facial Plastic Surgery” This review suggests that platelet-rich plasma is a low-risk treatment for androgenic alopecia with good patient satisfaction and positive objective outcomes, but further research is needed to refine methods and standardize outcome measurements.