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GlossaryQuantitative Real-Time PCR (qPCR)

laboratory technique to amplify and quantify DNA in real-time

Quantitative Real-Time PCR (qPCR) is a laboratory technique used to amplify and simultaneously quantify a targeted DNA molecule. It allows scientists to measure the amount of DNA in a sample in real-time, making it a powerful tool for diagnosing diseases, studying gene expression, and detecting genetic mutations.

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Expression and Distribution of the Guanine Nucleotide-Binding Protein Subunit Alpha-S in Mice Skin Tissues and Its Association with White and Black Coat Colors

research Expression and Distribution of the Guanine Nucleotide-Binding Protein Subunit Alpha-S in Mice Skin Tissues and Its Association with White and Black Coat Colors

1 citations, January 2016 in “Asian-Australasian journal of animal sciences”

The protein GnÎ±s is found more in black mice than white mice and may influence their coat color.

research Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege

27 citations, January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Somatostatin may help protect hair follicles from immune attacks.

research Functional Analysis of Vitamin D Receptor Using Adenovirus Vector

4 citations, February 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

The study found that certain mutations in the vitamin D receptor can cause rickets and potentially affect hair growth.

Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth After FGF5 Treatment

research Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth After FGF5 Treatment

August 2019 in “Research Square (Research Square)”

Certain long non-coding RNAs in cashmere goats affect hair growth when treated with a specific growth factor.

research Lenalidomide Augments Differentiation of Cultured Hair Follicle Derived Melanocyte Stem Cells Into Functional Melanocytes

April 2023 in “Dermatology practical & conceptual”

Lenalidomide helps hair follicle stem cells turn into melanocytes, which may improve repigmentation in vitiligo.

research An Efficient, Non-Invasive Approach for In Vivo Sampling of Hair Follicles: Design and Applications in Monitoring DNA Damage and Aging

12 citations, December 2021 in “Aging”

A new painless method to collect hair follicles helps study DNA damage and aging.

research Lgr6+ Stem Cells and Their Progeny in Mouse Epidermis Under Regimens of Exogenous Skin Carcinogenesis, and Their Absence in Ensuing Skin Tumors

7 citations, November 2016 in “Oncotarget”

UV exposure reduces Lgr6+ stem cells in mouse skin and they don't significantly contribute to skin cancer development.

research Tumor Cell Adhesion as a Risk Factor for SLN Metastasis and Predictor of Disease Recurrence in Primary Cutaneous Melanoma

April 2016 in “Journal of Investigative Dermatology”

Tumor cell adhesion is linked to higher risk of SLN metastasis and melanoma recurrence, and a model including these factors predicts these outcomes better than one with just clinical data.

research The Murine Hair Follicle Is a Melatonin Target

September 2004 in “Experimental dermatology”

Melatonin directly affects mouse hair follicles and may influence hair growth.

Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

38 citations, June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

research Equine Dermatophytosis Caused by Nannizzia Gypsea - Molecular Diagnosis by qPCR

June 2024 in “ACTA SCIENTIAE VETERINARIAE”

qPCR is effective for quickly diagnosing fungal infections in horses.

research To Identify the Expression of Intracellular Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Alopecia Areata

November 2023

Alopecia areata patients have higher levels of certain immune receptors, suggesting new treatment possibilities.

research Enrichment of Specific Hair Follicle-Associated Cell Populations in Plucked Hairs Offers an Opportunity to Study Gene Expression Underlying Hair Traits

2 citations, December 2022 in “International journal of molecular sciences”

Plucked hairs can be used instead of skin biopsies to study hair traits because they contain specific cells related to hair.

research Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma

351 citations, February 2010 in “Nature Cell Biology”

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

research Using WGCNA to Identify Hub Genes of Skin Hair Follicle Development in Fetal Stage of Inner Mongolia Cashmere Goat

16 citations, December 2020 in “PloS one”

Researchers found WNT10A to be a key gene in developing goat hair follicles.

research In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators

173 citations, January 2014 in “Nature Cell Biology”

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

research Evaluation of Short-Term Hair Follicle Storage Conditions for Maintenance of RNA Integrity

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Hair follicles can be kept in RNAlater® at cool or room temperature for a week without harming RNA quality.

research Differential Expression of Keratin and Keratin-Associated Proteins Linked with Hair Loss in Spontaneously Mutated Inbred Mice

July 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Hair loss in certain mice is linked to changes in keratin-related genes.

research Transcription Factor FOXC1 Positively Regulates SFRP1 Expression in Androgenetic Alopecia

May 2021 in “Experimental Cell Research”

FOXC1 boosts SFRP1 in hair loss, suggesting new treatments.

research Deciphering the Mesodermal Potency of Porcine Skin-Derived Progenitors by Microarray Analysis

6 citations, April 2010 in “Cellular Reprogramming”

Pig skin cells can turn into mesodermal cells but lose their ability to become neural cells.

research Human Hair Proteins as Natural Reactive Oxygen Species Scavengers for In Vitro Applications

4 citations, November 2022 in “Journal of biomedical materials research. Part B, Applied biomaterials”

Human hair proteins, especially keratins, can protect cells from oxidative stress in lab settings.

research Evaluation of Hair Follicles as a Surrogate Tissue for Pharmacodynamic Response in Xenograft Tumors

January 2012

Hair follicles can be used to quickly assess drug effects in cancer treatment.

research Development of Autoimmune Hair Loss Disease Alopecia Areata Is Associated with Cardiac Dysfunction in C3H/HeJ Mice

18 citations, April 2013 in “PLOS ONE”

Mice with autoimmune hair loss showed signs of heart problems.

research Comparative Transcriptomic Analysis of Dermal Wound Healing Reveals De Novo Skeletal Muscle Regeneration in Acomys Cahirinus

24 citations, May 2019 in “PLOS ONE”

The African spiny mouse can fully regenerate its muscle without scarring, unlike the common house mouse.

research Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer

December 2023 in “Animals”

The research found genes and miRNAs that may control hair growth in Forest Musk Deer.

research Expression Patterns of TRα and CRABPII Genes in Chinese Cashmere Goat Skin During Prenatal Development

August 2015 in “Han'gug dongmul jawon gwahag hoeji/Han-guk dongmul jawon gwahak hoeji/Journal of animal science and technology”

TRα and CRABPII genes change their activity levels during goat fetal skin development.

research Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin cells and certain hair follicle areas produce hemoglobin, which may help protect against oxidative stress like UV damage.

EDA and EDAR Expression at Different Stages of Hair Follicle Development in Cashmere Goats and Effects on Expression of Related Genes

research EDA and EDAR Expression at Different Stages of Hair Follicle Development in Cashmere Goats and Effects on Expression of Related Genes

12 citations, December 2020 in “Archives animal breeding/Archiv für Tierzucht”

EDA and EDAR are important for hair follicle development in cashmere goats and affect other related genes.

research A New Path in Defining Light Parameters for Hair Growth: Discovery and Modulation of Photoreceptors in Human Hair Follicle

70 citations, April 2017 in “Lasers in surgery and medicine”

Blue light promotes hair growth by interacting with specific receptors in hair follicles.

Studying Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

research Studying Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

2 citations, December 2019 in “Al-ʻulūm al-ṣaydalāniyyaẗ”

The CTLA-4 gene change studied does not affect Polycystic Ovarian Syndrome in the women tested.