20 citations
,
March 2023 in “Drug Delivery and Translational Research” This study found that a lacticin 3147 solid lipid nanoparticle gel demonstrated potent and sustained antimicrobial activity against S. aureus, including MRSA, in ex vivo S. aureus-infected pig skin.
20 citations
,
October 2018 in “Aesthetic Plastic Surgery” This review discusses the potential mechanisms of platelet-rich plasma in facial rejuvenation and reports no new clinical results, indicating a theoretical basis for its use in tissue regeneration.
20 citations
,
July 2015 in “Journal der Deutschen Dermatologischen Gesellschaft” This review summarizes the anticarcinogenic, anti-inflammatory, and other health effects of green tea, noting its historical and ongoing use in dermatological and cosmeceutical applications, but reports no new clinical results.
19 citations
,
May 2006 in “Clinical and Experimental Dermatology” This study identified a novel insertion mutation in the hairless gene that may contribute to the development of congenital atrichia with papular lesions in a Pakistani family.
18 citations
,
February 2023 in “PLoS ONE” This study developed a triple drug delivery system using nanoparticles loaded with 5-fluorouracil, curcumin, and piperine to target breast tumors, demonstrating notable in vitro cytotoxicity and anti-metastatic potential in 3D tumor spheroids which suggests its promise for further preclinical evaluation.
18 citations
,
January 2019 in “Animal Biotechnology” This study found that lncRNA-000133 may play a role in secondary hair follicle reconstruction and cashmere fiber growth in goats, potentially through its interaction with the methylation of its regulatory region and dermal papilla cells.
18 citations
,
December 2010 in “Journal of Trace Elements in Medicine and Biology” This study suggests that alterations in copper metabolism may play a key role in the development of androgenetic alopecia in women, presenting potential targets for treatment strategies.
17 citations
,
March 2021 in “Expert Opinion on Biological Therapy” This review analyzes the impact of different preparation methods for platelet-rich plasma, human follicles stem cells, and adipose-derived stem cells on hair regrowth and wound healing, but reports no new results; the authors emphasize convincing evidence of positive outcomes despite protocol variability.
17 citations
,
November 2017 in “PLoS ONE” This study observed dynamic behaviors such as cluster formation, migration, and active proliferation of transplanted bone marrow cells in a mouse model, providing insight into cellular-level changes post-transplantation.
17 citations
,
August 2015 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study concluded that the best approach for detecting Androsta-1,4,6-triene-3,17-dione administration in horses is monitoring the metabolites M1b or M4 in urine, detectable up to 77 hours post-administration.
17 citations
,
January 2014 in “Stem Cells Translational Medicine” This study reports that epidermal neural crest stem cells from dogs (cEPI-NCSC) can generate neural crest derivatives and may offer a new cell-based therapy for canine spinal cord injury, with potential as a model for human treatments.
16 citations
,
September 2018 in “Journal of Molecular Liquids” This study investigated a nanostructured system using PS-b-PAA diblock copolymer for incorporating the hydrophobic photosensitizer ClAlPc, finding it effective in causing cellular damage in Caco-2 cells under light while demonstrating no cytotoxicity without light, suggesting its potential use in photodynamic therapy.
15 citations
,
November 2020 in “Pharmaceutics” In this ex vivo and mouse model study, Tofacitinib-loaded nanoparticles demonstrated enhanced delivery of the drug into hair follicles and reduced inflammatory effects compared to conventional forms, indicating potential for safer, topical use in treating alopecia areata.
14 citations
,
April 2021 in “Biology” This study found that ethanol extract of Tubtim Chumphae rice bran downregulates SRD5A gene expression, similarly to finasteride, suggesting potential use as an anti-hair loss product.
14 citations
,
November 2020 in “International Journal of Molecular Sciences” This review article summarizes the potential role of advanced medical therapies—using genes, cells, and/or tissue engineering—in treating various types of alopecia, by examining clinical research, basic studies, and ongoing trials.
14 citations
,
December 2013 in “Molecules” This study identified a new lignan and 21 known compounds from Asiasarum heterotropoides roots, with two compounds showing potential anticancer activity by influencing NO production, FOXP3 expression, and HIF-1α activity in vitro.
13 citations
,
September 2024 in “Frontiers in Pharmacology” This review highlighted the pharmacological potential of Mor, noting its protective effects on the kidneys, liver, bones, nervous system, heart, digestive system, skin, and lungs, as well as its anti-obesity and anti-inflammatory properties, revealing areas for future research.
13 citations
,
October 2012 in “InTech eBooks” Nanocarriers could improve how drugs are delivered through the skin but require more research to overcome challenges and ensure safety.
13 citations
,
April 1994 in “Journal of Investigative Dermatology” Androgen receptors found in monkey scalps, similar to humans, affect hair growth.
12 citations
,
February 2025 in “Scientific Reports” This study found that extracellular vesicles derived from mesenchymal stem cells and umbilical cord blood plasma enhanced wound healing and reduced scar formation in mice, suggesting their potential as therapeutic agents for skin repair.
12 citations
,
January 2014 in “Annals of Dermatology” This study found an association between hydroxyl radical-modified SOD and alopecia areata, suggesting these modifications may lead to antibody induction in the condition.
12 citations
,
June 2012 in “Revista da Sociedade Brasileira de Medicina Tropical” This case study reported a rare infection by Trichosporon inkin, causing white piedra in a family in Southern Brazil, emphasizing the importance of molecular tools for precise identification.
12 citations
,
June 2001 in “Bioorganic & Medicinal Chemistry” This study found that octahydrobenzo[c]quinolizin-3-one derivatives, particularly compound 3, were potent and selective inhibitors of the enzyme 5α-reductase type 1.
11 citations
,
October 2021 in “Journal of Herbmed Pharmacology” This review examines the therapeutic benefits, chemical composition, and medicinal uses of Delphinium species, along with their toxic effects; it reports no new clinical results.
11 citations
,
April 2021 in “Advanced synthesis & catalysis” This study reports that the dye peri-xanthenoxanthene (PXX) can act as an efficient photocatalyst for various radical reactions, including complex dual catalytic processes and the synthesis of an investigational drug intermediate.
11 citations
,
February 2021 in “Trends in Food Science and Technology” This review explores the potential of edible flowers, particularly the genus Impatiens, for their chemical, nutritional, and bioactive properties but does not report new clinical findings.
11 citations
,
March 2019 in “Journal of Medicinal Chemistry” This study reports that synthetic carbohydrate receptors effectively inhibit Zika virus infection in cell cultures by blocking early stages of viral entry.
11 citations
,
December 2018 in “Assay and Drug Development Technologies” This review highlights the challenges in screening for steroid 5 alpha-reductase inhibitors and discusses significant variability in the effectiveness of finasteride and dutasteride, calling for standardized testing methods to develop safer, more specific inhibitors from herbal preparations.
11 citations
,
October 2018 in “Nucleic Acid Therapeutics” This study suggests that transfection with modified KGF-mRNA enhances keratinocyte reepithelialization in wound therapy by temporarily increasing growth factor expression without affecting nuclear DNA.
11 citations
,
October 2017 in “International Journal of Molecular Sciences” In this study, oil body-bound oleosin-rhFGF-10 was more efficiently absorbed through the skin and enhanced wound healing and hair growth in mice, compared to prokaryotically-expressed rhFGF-10.