July 2013 in “Our Dermatology Online” An 11-year-old male with widespread alopecia areata, covering over 40% of his scalp, did not respond to topical tacrolimus and corticosteroids. He was then treated with oral methylprednisolone pulse therapy (500 mg/day for three consecutive days each month). After six months, the patient experienced 80% hair regrowth in the affected area.
January 2003 in “Journal of Practical Aesthetic and Plastic Surgery” Both steroid treatments effectively regrow hair in severe alopecia areata.
October 2023 in “Dermatology practical & conceptual” Pulse corticosteroids help regrow hair in alopecia areata but have side effects, especially betamethasone.
39 citations,
January 2012 in “Dermatology” Combining high-dose corticosteroids with methotrexate may be effective and safe for severe alopecia areata.
27 citations,
May 2011 in “Journal of dermatology” Methylprednisolone pulse therapy works best for recent and specific types of severe alopecia areata.
22 citations,
August 2006 in “Journal of the European Academy of Dermatology and Venereology” Twice-weekly 5 mg betamethasone helps hair regrowth in alopecia areata.
19 citations,
January 2013 in “Annals of Dermatology” This retrospective study investigated the effects and safety of high-dose steroid pulse therapy, both oral and intravenous, on severe alopecia areata (AA) in 85 patients treated between 1999 and 2010. The overall satisfactory response rate was 51.8%, with a mean follow-up time of 37.6 months and a relapse rate of 22.7%. Patients with AA of recent onset (within one year) had significantly higher response rates (p<0.001) and lower relapse rates compared to those with AA persisting for more than one year. Early treatment also showed a 47% satisfactory response rate in severe cases like alopecia totalis, alopecia universalis, or ophiasis type. The study concluded that oral steroid pulse therapy was as effective and well-tolerated as intravenous therapy, suggesting it as the first-line treatment for severe AA of recent onset.
16 citations,
March 1996 in “PubMed” Switching to twice-weekly betamethasone led to full hair regrowth in 3 months without side effects.
14 citations,
January 2015 in “Annals of dermatology/Annals of Dermatology” Corticosteroid pulse therapy is more effective for severe alopecia areata than combination therapy.
14 citations,
January 2015 in “Indian journal of dermatology, venereology, and leprology” Methylprednisolone infusions can help some people with severe alopecia regrow hair.
20 citations,
October 2003 in “The Journal of Dermatology” DCP therapy causes side effects like weakness, flushing, headaches, and taste changes, but less frequently causes hypertension and diabetes.
17 citations,
November 2009 in “Dermato-endocrinology” Medium-dose prednisolone pulse therapy is effective and safe for multifocal alopecia areata but not for more severe forms.
May 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Intravenous methylprednisolone helped over half of alopecia areata patients regrow hair, but many relapsed.
October 2021 in “Dermatology practical & conceptual” High-dose corticosteroids can significantly regrow hair in severe alopecia areata.
November 2016 in “Faridpur Medical College Journal” Betamethasone oral mini-pulse therapy showed good or fair results in treating lichen planus.
March 2022 in “Nepal Journal of Dermatology Venereology & Leprology” Methotrexate with steroids is slightly more effective than azathioprine with steroids for treating severe alopecia areata.
January 2007 in “Yearbook of Dermatology and Dermatologic Surgery” Intramuscular triamcinolone and pulse therapy with oral predonine are effective for alopecia areata with manageable side effects, but better relapse prevention is needed.
8 citations,
July 2018 in “The Journal of Dermatology” Current corticosteroid pulse therapy is not very effective for severe rapidly progressive alopecia areata.
January 2021 in “International journal of basic and clinical pharmacology” Hydroxychloroquine is less effective than betamethasone oral mini pulse therapy for treating alopecia areata.
1 citations,
November 2005 in “PubMed” Itraconazole effectively treats scalp fungus, with continuous use more effective than pulse therapy.
14 citations,
January 2011 in “International Journal of Trichology” Some people with severe, long-lasting baldness responded well to a specific combination treatment.
10 citations,
January 2019 in “Indian Journal of Dermatology” Weekly azathioprine pulse is a better alternative to corticosteroids for treating alopecia areata due to fewer side effects.
18 citations,
January 2017 in “Journal der Deutschen Dermatologischen Gesellschaft” High and low doses of prednisolone helped 62% of children with severe alopecia regrow hair with some weight gain and mild acne as side effects.
January 2001 in “대한피부과학회지” Oral minipulse therapy with betamethasone effectively promotes hair regrowth in alopecia areata with fewer side effects.
January 2001 in “대한피부과학회지” Minipulse therapy with betamethasone effectively promotes hair regrowth in alopecia areata with fewer side effects.
14 citations,
December 2010 in “Dermatologica Sinica” New treatments for hair loss show promise, but more development is needed, especially for tough cases.
5 citations,
January 2021 in “Recent patents on inflammation & allergy drug discovery” Childhood Alopecia Areata causes hair loss and requires varied treatments, with psychological support being crucial.
December 2011 in “InTech eBooks” Systemic corticosteroids can help treat rapidly spreading vitiligo but require more research for safer use.
41 citations,
September 2018 in “Australasian journal of dermatology” No systemic treatment for alopecia areata has strong evidence of effectiveness.
21 citations,
May 2017 in “Paediatric drugs” Individualized treatment plans are crucial for children with alopecia areata, with promising options like JAK inhibitors showing significant hair regrowth.