284 citations
,
February 2008 in “Pediatrics” This review discusses the potential impact of endocrine-disrupting chemicals and body size on pubertal onset and progression, highlighting critical gaps and priorities for future research without presenting new clinical results.
6 citations
,
May 2021 in “JAMA network open” This study reported that higher weight-for-age z scores and rapid weight gain during infancy, especially from birth to 3 months, were linked to an increased likelihood of puberty onset in girls.
January 2017 in “Springer eBooks” Understanding genes and hormones is crucial for managing male puberty and sex development disorders.
58 citations
,
December 2018 in “Nature Communications” This study found that male pattern baldness in European males is strongly heritable and associated with genetic markers linked to earlier puberty, bone density, and pancreatic function.
November 2014 in “John Wiley & Sons, Ltd eBooks” This review discusses hormones that affect acne and highlights a statistically significant link between a low-glycemic-load diet and reduced acne activity, but reports no new experimental findings.
3 citations
,
July 2015 in “Pediatrics in review” This review discusses factors influencing the earlier onset of puberty, such as obesity and exposure to endocrine-disrupting chemicals, and emphasizes the need for further research and public health policy development.
186 citations
,
February 1980 in “Clinical Endocrinology” This study observed that serum levels of oestradiol, testosterone, and androstenedione increase rapidly with the onset of puberty and continue to rise after menarche, with anovulatory cycles being common in early postmenarchal girls.
29 citations
,
July 2011 in “Pediatrics in review” This article reviews various aspects of puberty, particularly focusing on the staging of sexual maturity and the factors influencing pubertal onset, but reports no new empirical results.
40 citations
,
July 2016 in “Pediatrics in review” This article reviews puberty's onset, development, and the factors affecting it, including nutrition, obesity, and gender dysphoria, and reports no new clinical results.
This study found that while prepubescent female goats showed strong olfactory responses to active buck hair, this sensory stimulation alone did not advance the onset of puberty.
73 citations
,
May 2011 in “Annals of Epidemiology” This study found that childhood use of hair oils and perms was associated with earlier onset of menarche among women of various racial and ethnic backgrounds.
2 citations
,
January 2000 in “Pediatrics in review” This article discusses diagnostic evaluations and management strategies for isosexual precocious puberty, emphasizing the importance of accurate identification and appropriate treatment, but it provides no new clinical findings.
January 2011 in “Journal of biological research” This review discusses potential links between early-onset androgenetic alopecia and exposure to endocrine disruptors in adolescents, but reports no clinical results; the authors suggest further investigation.
13 citations
,
October 2006 in “Pediatrics in review” This review discusses the complexities and factors influencing the management of precocious puberty in children, concluding that genetic influences are more significant than environmental ones. It reports no new research findings.
May 2021 in “Journal of the Endocrine Society” This case report details a diagnosis of adult-onset isolated hypogonadotropic hypogonadism in a 23-year-old African American female, highlighting its genetic basis and treatment approach.
January 2025 in “BMC Pediatrics” In this study conducted among healthy Iranian girls in Isfahan province, researchers found that the median onset age for menstruation was 12.05 years, breast development began at 9.89 years, and pubic hair development started at 10.14 years, with earlier puberty onset potentially indicating precocious puberty.
20 citations
,
May 1998 in “PEDIATRICS” This correspondence highlights a study on early pubertal development in young girls, noting that early pubic hair and breast development in African-American girls is likely due to increased androgen production, not estrogen or exogenous causes.
11 citations
,
February 2003 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology” This review discusses the relationship between acne, body hair, and androgenic stimulation in adolescent girls, emphasizing treatment decisions based on disease severity rather than endocrine findings.
29 citations
,
February 2016 in “Scandinavian journal of urology” This study suggests a possible link between late puberty onset and decreased prostate cancer risk, while over-the-counter ibuprofen use was associated with increased risk.
This study found that hair and nails can effectively measure hormone changes such as testosterone, estrogen, and progesterone during the peripubertal period in dogs, with variations observed between males and females at specific developmental stages.
April 2014 in “The FASEB Journal” This study examined 12 women with androgenetic alopecia and found that many had other symptoms linked to hyperandrogenism, suggesting the importance of further hormone level investigations.
February 2005 in “Journal of The American Academy of Dermatology” This discussion covers various nail disorders, including tumors and non-neoplastic issues, emphasizing that not all nail abnormalities are due to fungal infections, but it reports no new clinical findings.
2 citations
,
July 2008 in “Paediatrics & child health” This case report describes a 10-year-old girl with advanced puberty signs and resistant acne, highlighting potential early-onset puberty with associated growth patterns.
169 citations
,
November 2009 in “The Journal of Clinical Endocrinology & Metabolism” This study found that prepubertal girls have significantly higher levels of estrogens and androgen metabolites compared to age-matched boys, which may contribute to their earlier onset of puberty.
October 2005 in “CRC Press eBooks” This abstract discusses the prevalence and typical onset of androgenetic alopecia but reports no clinical findings.
30 citations
,
March 1980 in “European Journal of Endocrinology” This study suggests that genetic factors significantly influence adrenal androgen levels and the progression of puberty, with adrenal cortex maturation appearing independent of the hypothalamic-pituitary-gonadal axis.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study introduces a hypothesis that elevated DHT at puberty may cause chronic thermal stress in specific scalp areas, potentially explaining Androgenetic Alopecia characteristics and guiding future research.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This paper introduces a hypothesis that elevated DHT at puberty may increase cerebral heat output, creating chronic thermal stress linked to androgenetic alopecia, and suggests this could be tested with MR thermometry.
April 2025 in “Brazilian Journal of Hair Health” This article suggests that cultural and environmental influences, such as exposure to sexualized content, stress, poor sleep, and unhealthy diets, may accelerate androgenetic alopecia onset by affecting hormonal systems, gene expression, and hair follicle health, despite its genetic basis.
8 citations
,
January 2022 in “BMC Biology” This study found that the gene SRD5A1, associated with methylation changes due to early-life environment, may play a role in altering reproductive phenotypes in women by delaying pubertal onset and decreasing ovarian reserve.