305 citations
,
July 2016 in “International Journal of Biological Macromolecules” This review describes the roles of polysaccharides in antitumor, antiviral, and anti-inflammatory activities and introduces methods for their isolation and purification, reporting no new research results.
294 citations
,
August 1999 in “Journal of the American Academy of Dermatology” This study observed that the majority of side effects from laser-assisted hair removal were associated with ruby and alexandrite lasers, particularly in patients with tanned or darker skin types.
284 citations
,
February 2008 in “Pediatrics” This review discusses the potential impact of endocrine-disrupting chemicals and body size on pubertal onset and progression, highlighting critical gaps and priorities for future research without presenting new clinical results.
216 citations
,
September 2020 in “Scientific African” This review discusses the potential of pumpkin seeds as a functional food ingredient, highlighting their promising bioactive compounds and health benefits, but reports no new clinical results.
169 citations
,
November 2009 in “The Journal of Clinical Endocrinology & Metabolism” This study found that prepubertal girls have significantly higher levels of estrogens and androgen metabolites compared to age-matched boys, which may contribute to their earlier onset of puberty.
143 citations
,
September 1991 in “Archives of Dermatology” In this study, patients with generalized pustular psoriasis were classified into subgroups to better understand the disease's variability and assist in treatment selection, highlighting the role of localized infections in triggering flares.
117 citations
,
February 1996 in “International Journal of Dermatology” This study found that monthly oral prednisolone pulses of 300 mg were effective and safe for treating widespread alopecia areata, with 58.3% of patients achieving cosmetically acceptable hair growth.
109 citations
,
April 1997 in “Journal of Lipid Research” This study found that pure linoleate deficiency in rats caused significant reductions in the accumulation of n-6 polyunsaturates and mild symptoms like growth retardation, compared to classical essential fatty acid deficiency.
105 citations
,
December 1995 in “British journal of dermatology/British journal of dermatology, Supplement” This retrospective study concluded that PUVA treatment is generally ineffective for alopecia areata, with low effective success rates for partialis, totalis, and universalis types.
99 citations
,
May 2013 in “Familial cancer” This article discusses the pulmonary manifestations of Birt-Hogg-Dubé syndrome, noting diagnostic challenges in differentiating it from other lung conditions, and underlines the need for further research on folliculin's role in cyst formation.
96 citations
,
September 1975 in “The Journal of Clinical Endocrinology & Metabolism” In this study, significant elevations of DHA and testosterone were associated with pubic hair development and voice changes in boys during puberty.
95 citations
,
September 1979 in “Acta Paediatrica” This study found that serum DHEA levels increase earlier and are higher in girls compared to boys through various stages of puberty, reflecting their earlier pubertal development.
65 citations
,
June 2021 in “Frontiers in Pharmacology” This review examines the mechanisms of lung fluid imbalance in COVID-19-related pulmonary edema and suggests potential drug targets to improve management and reduce mortality.
63 citations
,
January 2006 in “Journal of cosmetic and laser therapy” This study found that pulsed infrared diode laser therapy (904 nm) was effective in promoting hair regrowth in 94% of patients with resistant patches of alopecia areata.
57 citations
,
February 1983 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study found that pubic skin fibroblasts respond to androgens, increasing 5α-reductase activity via an androgen receptor-mediated mechanism, suggesting its potential as a marker of androgen action in vitro.
54 citations
,
November 2014 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study found that combining low-fluence Q-switched Nd: YAG laser and intense pulsed light led to faster and more effective melasma treatment compared to using the laser alone, though recurrence still occurred.
53 citations
,
January 2006 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” In this study, reduced androgen receptor gene methylation and shorter CAG repeats in children with premature pubarche may lead to increased hair follicle sensitivity to steroid hormones, potentially causing early pubic hair development.
50 citations
,
January 2016 in “Journal of the American Academy of Dermatology” This systematic review of pulse corticosteroid therapy for alopecia areata found relatively low complete response rates, but responders experienced low relapse rates, indicating potential benefits for patients with favorable prognostic factors.
49 citations
,
May 2018 in “Endocrine” This study found that only eumenorrheic polycystic ovary syndrome patients showed a temporal coupling between kisspeptin and luteinizing hormone pulsatile secretions.
47 citations
,
November 2000 in “Archives of dermatology” In this observational study, the effectiveness of a diode laser was evaluated for treating pseudofolliculitis barbae at the Laser and Skin Surgery Center of New York, but it reports no new clinical results.
46 citations
,
June 2015 in “Fertility and Sterility” This study found that, among women with polycystic ovary syndrome, insulin resistance was significantly associated with an increased risk of depression, even after accounting for factors like BMI.
45 citations
,
August 2013 in “Facial Plastic Surgery Clinics of North America” This article reviews factors affecting follicular unit extraction, emphasizing the need to tailor procedures to individual patient characteristics, but reports no new experimental findings.
42 citations
,
October 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers identified two distinct homozygous mutations in the KRT85 gene among consanguineous Pakistani families with pure hair and nail ectodermal dysplasia, highlighting variations in severity and potential impacts on the K85 protein function.
41 citations
,
April 2006 in “Journal of Pediatric and Adolescent Gynecology” Shaving caused a mild, itchy pubic rash with small bumps and crusts.
40 citations
,
July 2016 in “Pediatrics in review” This article reviews puberty's onset, development, and the factors affecting it, including nutrition, obesity, and gender dysphoria, and reports no new clinical results.
39 citations
,
April 2003 in “Australasian journal of dermatology” This study found that PUVA treatment resulted in complete hair regrowth in over half of patients with alopecia areata totalis or universalis, despite a higher treatment failure rate in those with a family history of the condition.
38 citations
,
January 2013 in “Dermatology” This study found that intravenous high-dose pulse corticosteroids resulted in a complete response in 38% of children with alopecia areata, but the majority of responders relapsed within a year.
36 citations
,
January 2014 in “Evidence-based Complementary and Alternative Medicine” This study found that men with androgenetic alopecia treated with pumpkin seed oil for 24 weeks experienced a notable 40% increase in hair count compared to a 10% increase with a placebo.
34 citations
,
August 2011 in “Journal of Natural Medicines” This study found that Puerariae Flos extract inhibited testosterone 5α-reductase and promoted hair growth in mouse models, suggesting its potential use for treating androgenic alopecia.
33 citations
,
December 2013 in “Journal of cutaneous pathology” A fungal infection can look like a different scalp condition in teens, leading to wrong treatment until proper tests are done.