Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that sulforaphane-rich broccoli sprout extracts reduced UV-induced erythema by 37.7% in humans, suggesting a protective strategy against UVR damage.

The study found that IPI-926 was well tolerated up to 160 mg once daily for 28-day cycles and showed activity as a single-agent treatment in Hedgehog pathway inhibitor-naïve patients with basal cell carcinoma.

This study found that a topical hedgehog agonist can stimulate hair growth by promoting the transition from the resting to growth phase of the hair cycle in adult mouse skin.

This review discusses the role of the hedgehog signaling pathway in hematological cancers and its potential as a therapeutic target; it reports no new clinical findings.

In this study, topical CUR61414 was effective in inhibiting basal cell carcinomas in mice, but no clinical activity was observed in human trials.

This study found that men with early-onset androgenic alopecia have a higher risk of needing coronary revascularization before age 60 compared to those with later onset or no hair loss.

This study found that serum ferritin levels were lower in premenopausal women with female pattern hair loss compared to healthy controls, suggesting a potential role for iron in hair loss.

This study found that enhanced expression of the Sonic hedgehog gene via an adenovirus vector accelerated hair regrowth in mice with chemotherapy-induced alopecia.

This review examines the roles of Hedgehog and Gli proteins in mouse embryonic mammary development and suggests that Gli3-repressor-mediated off-state of Hedgehog signaling determines mammary fate over hair follicle fate.

This review examines the interaction between hedgehog and Wnt/β-catenin signalling in hair follicles and basal cell carcinoma, linking Hh pathway inhibition to both tumor regression and alopecia.

This study reported that Indian hedgehog (Ihh) signaling plays a crucial role in regulating tumor progression and metastasis in epithelial cancers, with Ihh deficiency leading to increased malignancy and metastasis in mice.

This study found no improvement in male-pattern hair loss after six months of using laser hair-comb therapy in two men.

This study found that vismodegib was effective in treating basal cell carcinoma, achieving complete remission in some patients; however, significant side effects often required careful management to prevent therapy suspension, which can lead to resistance.

This case report identifies two specific mutations in the WRN gene in a 40-year-old female with Werner syndrome, highlighting the need for awareness of its early manifestations and treatment options.

A woman had 13 non-cancerous cysts on her scalp successfully removed in one surgery.

This study found that applying topical thymidine dinucleotide (pTT) to newborn mice before UV exposure delayed and reduced melanoma development compared to untreated controls.

This perspective discusses Villani et al.'s findings on the role of the IGF regulatory protein Igfbp2 in basal cell carcinogenesis and highlights potential therapeutic and preventive targets, while raising questions about the cell of origin.

This article discusses the complex biological functions and social significance of hair follicles and reports no new research findings, emphasizing their role in health, disease, and a substantial beauty industry.

This study found that in patients undergoing allogeneic hematopoietic stem-cell transplantation, older age significantly increases the risk of hemorrhagic cystitis, especially in males, who are also affected by prostatic hyperplasia.

A cancer patient developed a type of hair loss after starting a cancer drug called vandetanib.

In this study, CD4+ non-haematopoietic, skin-resident stem cell-like populations were identified in both murine and human epidermis, suggesting they may serve as potential basal cell carcinoma precursors.

This thesis found that desmoplakin mutations in cardiocutaneous syndrome are linked to dose-dependent disease severity and identified mechanisms by which KLHL24 mutations cause cardiomyopathy, with rescue experiments successfully preventing this phenotype in patient-derived heart tissues.

This study explored how long non-coding RNA mediates the effects of FGF5 on the hair follicle development and villus growth of Liaoning cashmere goats.

In preclinical studies, topical CUR61414 reduced Hh signaling and shrank BCCs in mice, but this study found no clinical efficacy in human superficial or nodular BCCs.

The document covers various dermatological conditions and their studies.

Hair graying is caused by the loss of pigment cells due to poor maintenance of stem cells in the hair follicle.

In this study, researchers reported that the SHBG +5790 G>A polymorphism was associated with an increased risk of developing resistance to hormonal castration in advanced prostate cancer patients.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.

This study found that off-pump coronary surgery significantly reduces in-hospital morbidity compared to on-pump surgery without affecting midterm outcomes in the first 1-3 years after the procedure.