90 citations
,
January 2021 in “Clinical Endocrinology” This review discusses the impact of weight gain and obesity on the development of polycystic ovary syndrome and explores lifestyle strategies to manage the condition, without reporting new clinical results.
87 citations
,
July 2018 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research” This review discusses the essential roles and complex regulation of PP2A in various physiological processes and reports no clinical results; the authors highlight the need for further mouse model research to explore PP2A's therapeutic potential.
64 citations
,
May 2003 in “Journal of health psychology” This study found that women with PCOS reported higher overall psychological distress, but there was no significant link between their perceived hirsutism and this distress.
59 citations
,
December 2016 in “Supportive Care in Cancer” This study found that symptom clusters in patients undergoing chemotherapy for breast cancer are stable over time, suggesting that targeting core symptoms may help reduce symptom burden.
58 citations
,
April 2017 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that patients with post-finasteride syndrome exhibited major depressive disorder, severe erectile dysfunction, and neuropathy, alongside altered neuroactive steroid levels in cerebrospinal fluid.
56 citations
,
July 2014 in “PLoS ONE” This study found that midazolam improved PTSD-associated behavioral deficits in rats through its action on the TSPO, CBR, and neurosteroidogenesis pathways.
42 citations
,
July 2015 in “Cosmetics” This review discusses the use of cosmetic nanocarriers to improve hair appearance and reports no new experimental results.
40 citations
,
December 2019 in “Neurobiology of Stress” This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.
40 citations
,
July 2017 in “Frontiers in Medicine” This review highlights that in children, hair loss can be attributed to diverse conditions like alopecia areata and tinea capitis, and stresses the importance of a holistic approach to diagnosis and management, including psychosocial support due to limited effective treatments.
37 citations
,
October 2004 in “Adolescent Medicine Clinics” This article discusses the application and considerations of bariatric surgery for adolescents with severe obesity, highlighting the need for specialized programs but reporting no new clinical results.
34 citations
,
April 2014 in “Psychopharmacology” This review discusses the pharmacological properties and physiological regulation of neuroactive steroids, focusing on their varied responses to stress and ethanol in rats, mice, and humans, but it reports no new findings.
30 citations
,
August 2018 in “Dermatology and Therapy” This review discusses the diagnostic and treatment challenges of trichotillomania and emphasizes the need for better-designed studies to optimize treatment approaches.
27 citations
,
January 2017 in “Neuropsychopharmacology” This study found that acute sleep deprivation enhanced 5α-reductase expression and activity in the rat prefrontal cortex, and finasteride treatment reduced associated psychosis- and mania-like behaviors.
27 citations
,
January 2016 in “Quality of Life Research” This study developed and validated a 50-item questionnaire, the PCOSQ-50, to effectively assess the quality of life in Iranian women with polycystic ovary syndrome, addressing aspects often missed by previous questionnaires.
27 citations
,
March 1994 in “Harvard Review of Psychiatry” This review discusses trichotillomania's clinical features, prevalence, and treatment options, highlighting the potential benefits of behavior therapy and pharmacotherapy but reports no new clinical findings.
25 citations
,
June 2017 in “Molecular and Cellular Endocrinology” This review discusses the negative effects of anabolic androgenic steroids on various organ systems in men and reports no new results, highlighting the need for physician awareness.
25 citations
,
June 2012 in “Endocrine” This review discusses emerging concepts in PCOS from the AEPCOS 2010 meeting and reports no clinical findings; it suggests that the transition of care in congenital adrenal hyperplasia could inform PCOS adolescent care.
23 citations
,
August 2018 in “Anais Brasileiros De Dermatologia” This study found that patients with androgenetic alopecia reported more impact on their quality of life in terms of emotions, functioning, and symptoms than those with alopecia areata.
20 citations
,
June 2017 in “Hormone Molecular Biology and Clinical Investigation” This study found that long-term dutasteride therapy in men with benign prostatic hyperplasia worsened erectile dysfunction, reduced testosterone levels, and increased blood glucose and lipid profile, indicating negative metabolic impacts.
18 citations
,
March 2020 in “Frontiers in Neuroendocrinology” This study suggests that synthetic steroid analogues or 5α-reductase modulation could be potential therapeutic strategies for nervous system disorders, but further research on their effects is necessary.
18 citations
,
November 2016 in “International clinical psychopharmacology” This study found that in a 10-week trial, inositol did not significantly reduce trichotillomania symptoms compared to placebo, although 42.1% of inositol-treated patients felt 'much or very much improved' at the study's end.
15 citations
,
March 2020 in “Anais Brasileiros De Dermatologia” This review discusses post-finasteride syndrome, characterized by persistent symptoms despite discontinuation, and concludes that its existence cannot be confirmed; individualized assessment is advisable for those with a history of depression, sexual dysfunction, or infertility.
15 citations
,
November 2015 in “Pharmacopsychiatry” This review discusses sexual dysfunction as a side effect of α-blockers and 5-ARIs for BPH/LUTS, highlighting methodological flaws in existing studies and the need for more rigorous research.
15 citations
,
September 2015 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses OCD spectrum disorders with dermatological symptoms, emphasizing their clinical features, neurobiology, and treatment options, while noting the need for more controlled studies.
15 citations
,
June 2014 in “Integrative cancer therapies” This study found that an 8-week practice of pranic meditation was associated with improved quality of life and mental health scores in breast cancer survivors, though further research is needed for confirmation.
11 citations
,
August 2015 in “PLOS ONE” This study found that finasteride has selective effects on oxidative stress and acetylcholinesterase activity in different brain regions in rats with thioacetamide-induced hepatic encephalopathy.
7 citations
,
February 2019 in “Journal of gynecology obstetrics and human reproduction” Patients with Polycystic Ovary Syndrome in this study had significantly higher anxiety and depression scores compared to controls, but showed no significant differences in temperament and character traits.
7 citations
,
May 2013 in “Optometry and vision science” This case report observed increased eyelash growth in a trichotillomania patient using bimatoprost 0.03% solution over four months.
7 citations
,
January 2009 in “Immunological investigations” This report describes a rare case of alopecia areata universalis developing in a child during the recovery phase of phenobarbital-induced anti-convulsant hypersensitivity syndrome, which suggests a mechanism involving lymphocyte-related immune responses.
6 citations
,
September 2024 in “Discover Psychology” This study observed that men who conform more strongly to traditional masculinity norms are likelier to undergo cosmetic surgery as a way to assert power, success, dominance, and sexual success.