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Glossary Psoriasiform Alopecia

chronic skin condition causing scalp inflammation and hair loss

Psoriasiform alopecia is a type of hair loss that occurs in conjunction with psoriasis, a chronic skin condition characterized by red, scaly patches. In this condition, the inflammation and scaling associated with psoriasis extend to the scalp, leading to hair thinning or bald patches.

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research Psoriatic Alopecia/Alopecia Areata‐Like Reactions Secondary to Anti‐Tumour Necrosis Factor‐Alpha Therapy

1 citations , August 2025 in “Australasian Journal of Dermatology”

This case series highlights that anti-TNF agents, though beneficial for autoimmune conditions, can cause a rare adverse reaction of psoriasiform alopecia areata, stressing the importance of specific histopathological features for accurate diagnosis and better management to avoid unnecessary drug discontinuation.

research TNF inhibitor induced alopecia: an unusual form of psoriasiform alopecia that breaks the Renbök mold

9 citations , January 2017 in “Dermatology Online Journal”

This study describes a distinctive hair loss pattern with features of psoriasis and alopecia areata linked to TNF-α inhibitors, noting various management options despite the lack of consensus guidelines.

Psoriatic Alopecia/Alopecia Areata–Like Reactions Secondary to Anti–Tumor Necrosis Factor-α Therapy: A Novel Cause of Noncicatricial Alopecia

research Psoriatic Alopecia/Alopecia Areata–Like Reactions Secondary to Anti–Tumor Necrosis Factor-α Therapy: A Novel Cause of Noncicatricial Alopecia

72 citations , February 2011 in “The American Journal of Dermatopathology”

This study found that anti-TNF therapy-induced alopecia exhibits distinct clinical and histopathological features and can mimic psoriatic alopecia and alopecia areata, with some patients improving with topical treatment.

research Alopecia secondary to anti-tumor necrosis factor-alpha therapy

42 citations , March 2015 in “Anais Brasileiros de Dermatologia”

This study reports two cases of alopecia associated with anti-TNF therapy, highlighting a new entity combining features of alopecia areata and psoriatic alopecia.

research Adalimumab-related alopecia in a patient affected by psoriasis

14 citations , January 2017 in “Dermatology Online Journal”

This case report describes a patient with psoriasis who developed alopecia with unique histological features after anti-TNF therapy, suggesting that such effects may require considering treatment suspension for severe cases.

research Case report: Psoriasiform eczema with immune-mediated comorbidities treated with upadacitinib

5 citations , August 2024 in “Frontiers in Immunology”

In this study, upadacitinib was reported as effective in rapidly treating psoriasiform eczema in five male patients and showed varying degrees of effectiveness on other immune-mediated comorbidities like alopecia areata, vitiligo, ulcerative colitis, and hidradenitis suppurativa.

research Adalimumab-induced psoriatic alopecia/alopecia areata-like reaction in a patient with Crohn's disease

9 citations , January 2015 in “Dermatology Online Journal”

This case report describes a patient with Crohn's disease developing alopecia and psoriasiform skin lesions while on adalimumab treatment.

research S3909 Paradoxical Psoriasis and Alopecia Areata After the Use of Anti-TNF in a Patient With Crohn's Cisease

1 citations , October 2024 in “The American Journal of Gastroenterology”

In this case report, a patient with Crohn's disease experienced alopecia and psoriasiform reactions attributed to anti-TNF therapy, which improved after switching to Ustekinumab.

Scalp Psoriasis: Alopecia and Treatment Challenges

research Scalp Psoriasis

July 2018 in “Elsevier eBooks”

This review discusses the diagnosis of alopecia in psoriasis, highlighting different hair loss types and the need to distinguish it from similar conditions, but reports no new clinical results.

research Disorders of hair growth and the pilosebaceous unit: Facts and controversies

4 citations , October 2013 in “Clinics in Dermatology”

This article discusses three controversial hair growth disorders but reports no new research findings; it explores alopecia areata incognita, pseudopelade of Brocq, and psoriasis-linked alopecia.

research Risk of Autoimmune Skin Diseases Associated With Immune Checkpoint Inhibitors: A Pharmacovigilance Analysis Using the FAERS Database

1 citations , January 2025 in “Dermatologic Therapy”

This study analyzed FAERS data to explore the risk and onset patterns of autoimmune skin diseases associated with immune checkpoint inhibitors, finding a strong association particularly with bullous pemphigoid and emphasizing the need for vigilant monitoring of these adverse effects.

research Cutaneous Side Effects of Modern Targeted Therapy and Immunotherapy in Patients with Dermatological Malignancies

June 2023 in “Cancers”

This article reviews the cutaneous side effects of immune checkpoint inhibitors and targeted therapies for skin cancers, noting that while generally mild, these effects can influence treatment decisions and quality of life, underscoring the need for physicians to be aware of these adverse reactions.

research P368 Rare skin disorders in IBD patients treated with anti-TNFs

2 citations , February 2014 in “Journal of Crohn's and colitis”

This study observed that 6.45% of IBD patients treated with anti-TNF therapy developed severe psoriasiform reactions, with notable cases of alopecia universalis suggesting a potential link to previous alopecia areata.

research 616 Updates in therapeutics for pediatric alopecia areata: A systematic review with evidence-based analysis

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study evaluated current treatments for pediatric alopecia areata and found that high potency topical steroids had the strongest supporting evidence, with promising results also observed for anthralin ointment and other treatments in lower-grade studies.

research Tumor necrosis factor-alpha inhibitor associated psoriasiform alopecia (drug-induced psoriasiform alopecia)

1 citations , April 2012 in “Informa Healthcare eBooks”

Some medications for inflammation can cause a condition with scalp rashes and hair loss, often linked to Crohn's disease, and may require treatment changes to prevent permanent hair loss.

Risk Factors for the Development of and Outcomes After Diagnosis of Autoimmune Alopecia Areata in Patients with Inflammatory Bowel Diseases

research Risk factors for the development of and outcomes after diagnosis of autoimmune alopecia areata in patients with inflammatory bowel diseases

April 2024 in “Research Square”

IBD patients treated with TNF antagonists may develop autoimmune alopecia areata, with severe cases less likely to improve.

research Infliximab-Associated Psoriasiform Alopecia

1 citations , October 2015 in “The American journal of gastroenterology”

This study reported two cases where infliximab-associated psoriasiform alopecia resolved with significant hair regrowth after stopping infliximab and using potent topical steroid treatment.

research Alopecia areata after dupilumab for atopic dermatitis

53 citations , January 2018 in “JAAD case reports”

This report describes the case of a patient who developed alopecia areata within five weeks of starting treatment for atopic dermatitis with dupilumab.

research Upadacitinib Efficacy for the Treatment of Concomitant Psoriasis and Alopecia Areata

December 2023

This case study observed that a patient with multiple refractory inflammatory conditions, including psoriasis, alopecia areata, and psoriatic arthritis, experienced significant improvements after three months of treatment with upadacitinib. The report suggests potential benefits of upadacitinib for similar conditions, recommending further clinical trials.

research Twenty nail dystrophy with alopecia areata in an atopic child

April 2019 in “International journal of research in dermatology”

This case report describes a 6-year-old child with twenty nail dystrophy and alopecia areata of the scalp.

Hair Regenerative Effect of Silk Fibroin Hydrogel with Incorporation of FGF-2-Liposome and Its Potential Mechanism in Mice with Testosterone-Induced Alopecia Areata

research Hair regenerative effect of silk fibroin hydrogel with incorporation of FGF-2-liposome and its potential mechanism in mice with testosterone-induced alopecia areata

12 citations , September 2018 in “Journal of Drug Delivery Science and Technology”

This study found that a new hydrogel formulation of basic fibroblast growth factor showed promise in promoting hair regrowth and reducing inflammation in testosterone-treated mice.

research Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts

131 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that alopecia areata can be induced and serially transferred in C3H/HeJ mice using skin grafts, providing a useful model for studying the disease in humans.

research Alopecia Areata: a Comprehensive Review of Pathogenesis and Management

99 citations , July 2017 in “Clinical Reviews in Allergy & Immunology”

This review noted that alopecia areata is an autoimmune disease impacting hair follicles and offered insights into its complex pathogenesis involving immune responses, while highlighting ongoing research into new treatments such as Janus kinase inhibitors and other immunomodulatory drugs.

research Transient Efficacy of Tofacitinib in Alopecia Areata Universalis

39 citations , April 2016 in “Case Reports in Dermatology”

This study observed initial hair regrowth in a businessman with alopecia areata universalis treated with tofacitinib, but the effect diminished, leading to renewed hair loss.

research Trichoscopic findings in alopecia areata and their relation to disease activity, severity and clinical subtype in Turkish patients

26 citations , August 2013 in “Australasian Journal of Dermatology”

This study found that certain trichoscopic patterns, like exclamation mark hairs, were associated with active or mild alopecia areata in Turkish patients, aiding in diagnosis and prediction of the disease.

Alopecia Areata: Pathogenesis, Genetic Factors, and Treatments Using Mouse Models

research Alopecia Areata

24 citations , January 2008 in “KARGER eBooks”

This review discusses recent advances in understanding the pathogenesis of autoimmune alopecia areata and reports no new clinical results; it highlights potential for developing more effective treatments.

research Platelet-Rich Plasma in the Treatment of Alopecia Areata: A Review

15 citations , October 2020 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses the potential use of platelet-rich plasma for treating alopecia areata but reports no new experimental findings, noting the need for standardized protocols and larger studies to evaluate its efficacy.

Increased Macrophage Migration Inhibitory Factor in the Sera of Patients with Extensive Alopecia Areata

research Increased Macrophage Migration Inhibitory Factor (MIF) in the Sera of Patients with Extensive Alopecia Areata

14 citations , March 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that serum MIF levels were significantly higher in patients with extensive alopecia areata compared to those with mild alopecia areata and healthy individuals.

research Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata

4 citations , July 2025 in “Frontiers in Immunology”

This study explored peripheral blood immune dysregulation in alopecia areata through single-cell analyses, identifying systemic changes linked to disease severity and key signaling roles for monocytes, NK cells, and memory T cells, suggesting potential therapeutic targets.

research Prolonged Drug-Induced Hypersensitivity Syndrome/DRESS With Alopecia Areata and Autoimmune Thyroiditis

2 citations , August 2022 in “Federal Practitioner”

This case report describes a patient with lamotrigine-associated drug-induced hypersensitivity syndrome requiring prolonged and complex treatment, with observed complications including extensive alopecia areata and autoimmune thyroiditis.