In this study, researchers identified specific gene polymorphisms in Subo Merino sheep that significantly affect wool traits, suggesting these genetic markers could aid in breeding high-quality fine-wool sheep.
February 2026 in “International Journal of Molecular Sciences” In this study, researchers identified 47 proteins associated with male pattern baldness severity and prioritized five candidate genes, including druggable CD38, suggesting new non-hormonal targets for therapeutic development.
Results are not reported in this abstract, which notes that while Janus kinase inhibitors like baricitinib show therapeutic benefits for alopecia areata, the mechanisms and reliable predictors of response remain unclear.
September 2025 in “Genes” In this study, researchers reported that specific gene polymorphisms in Jiangnan cashmere goats, particularly SNPs in the HOXC13 and WNT4 genes, were significantly associated with key economic traits like birth weight and yearling weight, providing molecular markers for breeding and enhancing economic trait stability.
In this study, ritlecitinib treatment for 12 and 24 weeks downregulated immunity-related genes and upregulated hair keratin genes in patients with alopecia areata, correlating with scalp hair regrowth response.
February 2025 in “BMC Veterinary Research” This study examined proteomic changes in Inner Mongolia cashmere goat skin, finding 631 proteins differentially regulated during hair growth stages; key keratin proteins, crucial for hair follicle development, were localized in secondary hair follicles.
This animal study found that YH0618 may alleviate doxorubicin-induced alopecia and affects proteins like keratin and Smad3, suggesting potential therapeutic targets. The researchers analyzed protein expression changes to understand YH0618's effects in treating chemotherapy-related hair loss.
January 2016 in “Hair therapy & transplantation” This study found that topical Hair UpTM appeared effective and safe for treating alopecia totalis and alopecia universalis, with high rates of terminal hair regrowth and notable cosmetic acceptability, particularly among minors.
This paper discusses advancements in forensic hair analysis, emphasizing a novel DART–HRMS method that improves the accuracy and efficiency of detecting drug use timelines.
21 citations
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April 2014 in “PLoS ONE” In this study, researchers identified a novel KRT74 gene mutation associated with autosomal recessive pure hair and nail ectodermal dysplasia in a Pakistani family, expanding the known genetic causes of the disorder.
8 citations
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July 2020 in “BMC genomics” In this study, ceruloplasmin and keratin 4 were identified as markers that differentiate between growing and resting phases in cashmere goat hair follicles, with keratin 4 being a potential marker for the onset of a new hair cycle.
July 2026 in “Veterinary Sciences” This study explored the decline in cashmere production in Inner Mongolian cashmere goats through RNA-seq analysis, finding that AKT1 expression and related signaling pathways are age-dependent, with peak AKT1 upregulation at 12 months aligning with peak cashmere production.
January 2026 in “Veterinary Sciences” In this study, researchers found that significant transcriptomic changes occur in the skin of Dezhou donkey foals as they age from newborns to one year old, involving gene expression shifts that may enhance skin barrier function and hair follicle development, while reducing collagen synthesis.
February 2025 in “Archives of Dermatological Research” Polynucleotides effectively promote hair regrowth in androgenetic alopecia without serious side effects.
October 2023 in “Biomedical science and engineering” Innovative methods are reducing animal testing and improving biomedical research.
24 citations
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April 2016 in “Experimental Dermatology” This study found that chemical treatments like perming, dyeing, and bleaching significantly alter amino acids and lipids in human hair, which may impact hair strength and quality.
1 citations
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July 2025 in “Biomaterials Advances” This study investigated how 2D and 3D cell culturing methods influence hair follicle morphogenesis, finding that 3D cultures responded more expectedly to minoxidil while 2D cultures reacted better to DHT treatment, challenging the assumption that 3D cultures are always superior.
March 2024 in “International journal of molecular sciences” This study found that human meibomian glands differ significantly from free and hair-associated sebaceous glands in morphology and lipid composition, making them highly specialized holocrine glands.
10 citations
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June 2024 in “Frontiers in Genetics” This study analyzed RNA-seq data from various animal breeds and suggested that similar molecular mechanisms may underlie wool fineness in different sheep breeds. Researchers identified 32 candidate genes related to hair follicle regulation, providing insights for molecular breeding and evolutionary studies.
48 citations
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February 2010 in “Molecular biology reports” This study found that KAP7.1 and KAP8.2 genes were significantly more expressed in secondary hair follicles than primary follicles, suggesting their role in regulating cashmere fiber diameter.
33 citations
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October 2020 in “Frontiers in Cell and Developmental Biology” In this study, researchers found that during zebrafish telencephalon regeneration, the lesioned hemisphere showed distinct gene expression changes and activated Wnt/β-catenin signaling early after injury, suggesting this pathway's significant role in recovery.
30 citations
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November 2019 in “Genetics selection evolution” This study found that in Chinese goat breeds, specific genetic variations, particularly in Tibetan Cashmere goats, are associated with traits like hair growth and adaptation to high-altitude environments.
25 citations
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January 2012 in “Proteome Science” This study suggests that common proteomic changes, including the expression of the protein S100A6, may occur during the expansion of AD-MSC from different donors.
10 citations
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December 2021 in “Frontiers in cell and developmental biology” This study used single-cell RNA sequencing to map the cellular composition of sheep hair follicles, revealing differentiation pathways and potential molecular mechanisms for wool curvature, which may inform sheep breeding.
1 citations
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October 2023 in “PROTOPLASMA” 1 citations
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February 2023 in “Pharmaceutics” This article reviews cell proteomic footprinting technology and its application in improving the authentication and quality control of cell-based immunotherapeutics, without providing new clinical results.
October 2024 in “Frontiers in Veterinary Science” This study identified key proteins, FKBP10 and FBN2, that promote the growth cycle of secondary hair follicles in cashmere goats, with higher expression in the anagen phase, offering insights into mechanisms potentially enhancing cashmere yield and quality.
14 citations
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June 2022 in “BMC genomics” This study identified key genes involved in hair follicle development in Merino sheep, offering insights for improving wool production and providing a basis for future breeding programs.
1 citations
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October 2023 in “Journal of plastic, reconstructive & aesthetic surgery” This meta-analysis reported that stem cell-derived conditioned medium effectively increases hair density and thickness in patients with alopecia, with longer treatment durations showing greater improvements.
1 citations
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March 2020 in “Meždunarodnyj medicinskij žurnal” This review examines platelet-enriched plasma as a potential new treatment for androgenetic alopecia but reports no new clinical results; the authors suggest standardizing its use based on alopecia stages.