April 2019 in “Journal of Investigative Dermatology” This study found that activating the Sonic hedgehog pathway in scarring wounds can redirect wound repair to favor hair follicle regeneration instead of fibrosis.
April 2019 in “Journal of Investigative Dermatology” In this pilot study, combined platelet-rich plasma therapies showed potential benefits for improving skin elasticity and vascular network density in morphea patients, but the small sample size limits definitive conclusions.
24 citations
,
October 2014 in “Cold Spring Harbor Perspectives in Medicine” Genetic research has advanced our understanding of skin diseases, but complex conditions require an integrative approach for deeper insight.
9 citations
,
January 2015 in “Current problems in dermatology” This review highlights recent genetic research advancements in understanding hereditary hair diseases but reports no new study results, emphasizing the identification of genes related to both monogenic and polygenic hair disorders.
4 citations
,
June 2021 in “Scientific Reports” This study found that examining hair morphology provides deeper insights than classification, suggesting a potential population stratification artefact between hair curvature and cross-sectional shapes in the examined admixed African-European sample.
February 2026 in “Dermatology and Therapy” This narrative review found that while AI-based tools in dermatology, particularly for hair disorder assessment, have potential to enhance clinical practice by improving objectivity and personalization, they currently serve mainly a complementary role and face challenges like methodological limitations and data bias.
January 2026 in “BIO Web of Conferences” This study suggests that fibroblast growth factors exhibit significant expression differences in rodent and primate skin, potentially related to their evolutionary paths and environmental adaptations.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, the researchers observed significant metabolic dysregulation in central centrifugal cicatricial alopecia, particularly involving lipid metabolism and the downregulation of AMPK-related genes.
January 2024 in “Research Square (Research Square)” This study identified key genes related to ischemic stroke through the ferroptosis pathway and highlighted the potential role of specific traditional Chinese medicines in regulating associated biological processes.
1533 citations
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October 2008 in “Endocrine reviews” This research highlights that engineered mice lacking the vitamin D receptor show multiple health issues similar to human vitamin D deficiency, underscoring the widespread impacts of the vitamin D endocrine system.
59 citations
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May 2017 in “Scientific reports” This study found that ZDHHC13 deficiency in mice is associated with abnormal liver function, lipid metabolism issues, and impaired mitochondrial function, highlighting ZDHHC13's regulatory role in liver metabolism.
27 citations
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March 2018 in “Biomaterials” This study found that a cocktail of three proteins from embryonic skin can enable adult fibroblasts to regenerate hair follicles by altering gene expression and activating regenerative signaling pathways.
December 2025 in “Frontiers in Veterinary Science” In this study, researchers explored hair follicle development in Qianhua Mutton Merino sheep, identifying key genes like KRT27 and IGF-2 that impact this process, with findings suggesting significant molecular changes as sheep mature from newborn to one year old.
April 2024 in “Journal of cancer research and clinical oncology” This review discusses the isolation, characterization, and potential clinical applications of tissue-derived extracellular vesicles in cancer diagnosis, prognosis, and treatment, noting their significance but highlighting the risks and need for appropriate protocols.
September 2022 in “Institutional Repositories DataBase (IRDB)” 3D-oxy exosomes may significantly boost hair growth, offering new treatment options for hair loss.
June 2020 in “Journal of Investigative Dermatology” This study observed that human primary adult hair matrix keratinocytes may have the potential to generate hair follicle organoids, suggesting possible applications in hair follicle neogenesis and preclinical hair growth agent screening.
November 2025 in “Frontiers in Veterinary Science” In this study, feeding H-line chickens a diet with 1.0% tyrosine for 40 days significantly increased melanin deposition in feathers and revealed changes in gene expression related to melanin pathways, suggesting tyrosine's involvement in regulating feather color through the EDNRB2 regulatory network.
25 citations
,
September 2014 in “Biological Research” This study found that arctiin, a compound from Arctium lappa, demonstrated protective effects against oxidative stress-induced dysfunction in human hair dermal papilla cells, suggesting potential therapeutic use for alopecia.
13 citations
,
March 2017 in “Genomics” This study reported that pathways related to apoptosis, cell proliferation, and WNT signaling might be key drivers of hair loss in androgenetic alopecia, guiding potential targets for therapy development.
140 citations
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August 2011 in “Biomaterials” This study observed that keratose, derived from human hair, integrated well in mouse tissue and remodeled with collagen, suggesting potential as a non-toxic biomaterial for regenerative applications.
136 citations
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January 2013 in “International Journal of Trichology” This study found that adding microneedling to minoxidil treatment significantly improved hair growth in men with androgenetic alopecia compared to minoxidil alone across all assessed measures.
134 citations
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January 2019 in “American journal of clinical dermatology” This review summarizes recent research on the skin microbiome's role in acne development and how antibiotic treatments affect skin microbes, but it reports no new clinical results.
87 citations
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July 2018 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research” This review discusses the essential roles and complex regulation of PP2A in various physiological processes and reports no clinical results; the authors highlight the need for further mouse model research to explore PP2A's therapeutic potential.
81 citations
,
December 2009 in “Journal of Dermatological Science” This review discusses the paracrine effects of adipose tissue-derived stem cells on surrounding cells and tissues, noting their potential therapeutic benefits, but reports no new clinical results.
77 citations
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February 2017 in “Stem Cell Reports” This study found that activation of Wnt/β-catenin signaling in mouse testes promotes spermatogonial differentiation and reduces the stem cell pool, with SHISA6 inhibiting this process and maintaining stem cell characteristics.
73 citations
,
July 2016 in “Cosmetics” This review discusses the use of mushrooms and their bioactive compounds in cosmeceuticals and nutricosmetics and reports no new clinical findings, highlighting potential areas for future research and development.
58 citations
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June 2018 in “Scientific reports” This study identified novel genetic associations with skin phenotypes such as age-spots, freckles, and hair characteristics in Japanese women, providing insights into the genetic basis of these traits.
55 citations
,
March 2015 in “Carcinogenesis” This study found that WNT10A is significantly upregulated in human esophageal squamous cell carcinoma and is associated with enhanced tumor cell migration, invasion, and poor survival.
49 citations
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November 2014 in “Journal of Medicinal Food” In this study, red ginseng extract and its ginsenosides enhanced human hair follicle cell proliferation and countered dihydrotestosterone-induced suppression, suggesting potential to promote hair growth.
42 citations
,
January 2018 in “Expert review of precision medicine and drug development” This review discusses the integration of drug repurposing with personalized medicine through off-label prescribing and reports no new results, highlighting the potential for systematic exploration using omics technologies.